Zobrazeno 1 - 10 of 51 pro vyhledávání: '"H. Saegesser"'
1
Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
Autor: Vreni Schneider, M. Ledermann, H. Saegesser, Juerg Reichen, Markus Neef
Publikováno v: Journal of Hepatology. 45:786-796
Background/Aims Mammalian target of rapamycin (mTOR) signalling is central in the activation of hepatic stellate cells (HSCs), the key source of extracellular matrix (ECM) in fibrotic liver. We tested the therapeutic potential of the mTOR inhibitor r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbeef5c31c11b4014c270e0a5b02787b
https://doi.org/10.1016/j.jhep.2006.07.030
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2
Oral imatinib treatment reduces early fibrogenesis but does not prevent progression in the long term
Autor: Nicolas Widmer, Markus Neef, Bertrand Rochat, M. Ledermann, Juerg Reichen, Vreni Schneider, H. Saegesser, Laurent A. Decosterd
Publikováno v: Journal of Hepatology. 44:167-175
Background/Aims: Transactivated hepatic stellate cells (HSCs) represent the key source of extra cellular matrix (ECM) in fibrotic liver. Imatinib, a potent inhibitor of the PDGF receptor tyrosine kinase, reduces HSC proliferation and fibrogenesis whe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8222afb1499304f92082df438a1737d
https://doi.org/10.1016/j.jhep.2005.06.015
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3
Endothelial nitric oxide synthase is not essential for the development of fibrosis and portal hypertension in bile duct ligated mice
Autor: M. Ledermann, Jürg Reichen, Abraham Koshy, Sidney Shaw, H. Saegesser, Andrea De Gottardi, Arthur Zimmermann
Publikováno v: Liver International. 25:1044-1052
BACKGROUND/AIMS: It is postulated that nitric oxide (NO) is responsible for the hyperdynamic circulation of portal hypertension. Therefore, we investigated induction of fibrosis and hyperdynamic circulation in endothelial NO synthase knock-out (KO) m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65606f5b4c6585237f39d27d8c318172
https://doi.org/10.1111/j.1478-3231.2005.01146.x
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4
Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis
Autor: M. Ledermann, Felix Stickel, Christoph Dorn, Vreni Schneider, Eleonora Patsenker, Claus Hellerbrand, H. Saegesser
Publikováno v: Journal of hepatology. 55(2)
Background & Aims Recurrence of chronic hepatitis C and progressive fibrosis in liver transplants is frequent and impairs both graft and patient survival. Whether or not the choice of immunosuppression affects progression of fibrosis remains unclear.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d436def1e0e846f51cb49749488da0
https://pubmed.ncbi.nlm.nih.gov/21554907
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7
Chronic Alcohol Feeding Stimulates the Formation of Mutagenic Etheno-Adducts in a Rodent model of NASH Via Induction of Cytochrome P450 2E1
Autor: Helmut-Karl Seitz, M. Ledermann, Sebastian Mueller, Eleonora Patsenker, H. Saegesser, Y. Wang, V Schneider, Felix Stickel
Publikováno v: Zeitschrift für Gastroenterologie. 47
Background and Aims: Chronic alcohol consumption may cause liver fibrosis and hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD). Synergistic effects of insulin resistance and alcohol triggering fibrogenesis and HCC are impli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::737393de7cf47ab2285953b286cf7766
https://doi.org/10.1055/s-0029-1191847
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