Zobrazeno 1 - 10
of 84
pro vyhledávání: '"H. S. Bachelard"'
Autor:
C. J. Brackenridge, H. S. Bachelard
Publikováno v:
International Journal of Protein Research. 1:157-168
1. The effects of various treatments on the extraction of acidic proteins and on enzymic activities in microsomal preparations of bovine cerebral cortex have been examined. After ultrasonic irradiation, density-gradient centrifugation demonstrated th
Autor:
H. S. Bachelard, Ronnitte Badar-Goffer
Publikováno v:
Journal of Neurochemistry. 61:412-419
Autor:
H. S. Bachelard
The brain is the most complex and highly of semi-permeable excitable membranes which specialised of all mammalian organs. Under can be caused, rapidly and transiently, to under standing the complexity of its function remains go changes in permeab
Autor:
H. S. Bachelard, Peter B. Jones, A G Taylor, Arne Schousboe, Niels Westergaard, Ursula Sonnewald
Publikováno v:
Journal of Neurochemistry. 67:2566-2572
Metabolism of [U- 13 C F ]glutamine was studied in primary cultures of cerebral cortical astrocytes in the presence or absence of extracellular glutamate. Perchloric acid extracts of the cells as well as redissolved lyophilized media were subjected t
Publikováno v:
Journal of Neurochemistry. 72:2471-2478
Under control conditions, superfused hippocampal slices exhibited a significantly higher phosphocreatine (PCr)/ATP ratio than cortical slices; the evidence suggests that this is due to lower concentrations of ATP, rather than higher concentrations of
Autor:
Andrew M. Taylor, Mary A. McLean, O. Ben-Yoseph, Nicola Thatcher, Malcolm Prior, H. S. Bachelard, R.S. Badar-Goffer, Peter G. Morris
Publikováno v:
Neurochemical Research. 27:51-58
Exposure of guinea pig brain slices to low concentrations (10 μM) of NMDA caused decreases in PCr and ATP within 30 min, with a slower decrease in NAA and increase in lactate, both detectable after 1 h. Exposure to NMDA for over 1 h or at higher con
Publikováno v:
Journal of Neurochemistry. 76:1057-1065
l-2-Chloropropionic acid is selectively toxic to the cerebellum in rats; the granule cell necrosis observed within 48 h can be prevented by prior administration of MK-801. Short-term treatment (2 h) with l-2-chloropropionic acid has also been shown t
Publikováno v:
Magnetic Resonance Imaging. 19:133-142
L-2-Chloropropionic acid (L-CPA) is selectively toxic to rat cerebellar granule cells; necrosis is first observed about 36 hours after administration of L-CPA (750 mg/kg p.o.) becoming more marked by 48 h. Parallel to the onset of cell death an incre
Autor:
H. S. Bachelard, P Jones
Publikováno v:
Neurochemical Research. 24:1327-1331
The transfer of label from 15N-alanine and 15N-glutamate into amino acids in incubated brain slices has been followed using gas chromatography/mass spectrometry (GC/MS). 15N from alanine appeared in both amino and amide groups of glutamine more rapid
Autor:
H. S. Bachelard
Publikováno v:
Neuroscience Research Communications. 18:143-153
Use of combinations of multiply-labelled precursors ([1-13C] glucose, [2-13C] glucose, [2-13C] acetate and [1,2-13C] acetate), with analyses of isotopomers of resonances in 13C-MR spectra, is proving to be a promising approach to investigating metabo