Výsledky vyhledávání - "H. Ruth Morse"

Akademický článek

IL-6 knockdown in a model of the human bone marrow, abrogates DNA damage induction in bystander cells post-chemotherapy induced cytokine release syndrome

Autor: Harshini S.H. Asurappulige, Michael R. Ladomery, H. Ruth Morse

Publikováno v: Translational Oncology, Vol 46, Iss , Pp 102030- (2024)

Following infection or exposure to therapeutic agents, an aggressive immune response may result, termed cytokine storm (CS) or cytokine release syndrome. Here the innate immune system becomes uncontrolled, leading to serious consequences including po

Externí odkaz: https://doaj.org/article/c8b13dcc3d564d83b7a2cf160285a72d

Zobrazit plný text záznamu

Akademický článek

Understanding Hydrogen: Lessons to Be Learned from Physical Interactions between the Inert Gases and the Globin Superfamily

Autor: John T. Hancock, Grace Russell, Tim J. Craig, Jennifer May, H. Ruth Morse, Jonathan S. Stamler

Publikováno v: Oxygen, Vol 2, Iss 4, Pp 578-590 (2022)

Hydrogen gas (molecular hydrogen, H2) has significant effects in a range of organisms, from plants to humans. Many inert gases have been reported to have similar effects, and such responses may be most pronounced when cells are stressed. Xenon (Xe),

Externí odkaz: https://doaj.org/article/c331ef61aa2043b596d2442ad98d7780

Zobrazit plný text záznamu

A novel in vitro 3D model of the human bone marrow to bridge the gap between in vitro and in vivo genotoxicity testing

Autor: Alexander R Vernon, Roy M Pemberton, H Ruth Morse

Publikováno v: Mutagenesis. 37:112-129

The regulatory 2D in vitro micronucleus (MN) assay is part of a battery of tests, used to test for genotoxicity of new and existing compounds before they are assessed in vivo (ICH S2). The 2D MN assay consists of a monolayer of cells, whereas the in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fde16736b192b9d0c73e67ca06f1d15
https://doi.org/10.1093/mutage/geac009

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Sponge–Microbial Symbiosis and Marine Extremozymes: Current Issues and Prospects

Autor: Praise Tochukwu Nnaji, H. Ruth Morse, Emmanuel Adukwu, Rachael U. Chidugu-Ogborigbo

Publikováno v: Sustainability. 14:6984

Marine microorganisms have great potential for producing extremozymes. They enter useful relationships like many other organisms in the marine habitat. Sponge–microbial symbiosis enables both sponges and microorganisms to mutually benefit each othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc08df4528617a944d8327b1167ab5f3
https://doi.org/10.3390/su14126984

Zobrazit plný text záznamu

Chemotherapy-induced genotoxic damage to bone marrow cells: long-term implications

Autor: H. Ruth Morse, Jennifer E. May, Craig Donaldson, Liana Gynn

Publikováno v: Mutagenesis. 33(3)

Mesenchymal stem/stromal cells (MSCs) within the bone marrow (BM) are vitally important in forming the micro-environment supporting haematopoiesis after myeloablative chemotherapy. MSCs are known to be damaged phenotypically and functionally by chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a590adab73638ae93171774845d21a19
https://pubmed.ncbi.nlm.nih.gov/30239865

Zobrazit plný text záznamu

Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells

Autor: Christopher P. Mintoff, Elizabeth Bowler, Michael Ladomery, Rachel M. Hagen, H. Ruth Morse, Veronica Sanda Chedea

Publikováno v: International journal of oncology. 43(1)

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ad6c8b838b1b73cba32bfd85cfe67f
https://pubmed.ncbi.nlm.nih.gov/23615977

Zobrazit plný text záznamu

Development of a novel, physiologically relevant cytotoxicity model: application to the study of chemotherapeutic damage to mesenchymal stromal cells

Autor: Craig Donaldson, Jinsheng Xu, H. Ruth Morse, Jennifer E. May

Publikováno v: Toxicology and applied pharmacology. 263(3)

There is an increasing need for development of physiologically relevant in-vitro models for testing toxicity, however determining toxic effects of agents which undergo extensive hepatic metabolism can be particularly challenging. If a source of such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e47a34590d37efd964f45c64efec9ee
https://pubmed.ncbi.nlm.nih.gov/22835568

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání