Zobrazeno 1 - 10
of 105
pro vyhledávání: '"H. Routh"'
Autor:
Suraj B. Teegala, Pallabi Sarkar, Dashiel M. Siegel, Zhenyu Sheng, Lihong Hao, Nicholas T. Bello, Luis De Lecea, Kevin D. Beck, Vanessa H. Routh
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101788- (2023)
Objective: The present study tests the hypothesis that changes in the glucose sensitivity of lateral hypothalamus (LH) hypocretin/orexin glucose-inhibited (GI) neurons following weight loss leads to glutamate plasticity on ventral tegmental area (VTA
Externí odkaz:
https://doaj.org/article/3e3e5feead66492db315da933d2eb502
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 823-833 (2016)
Objective: Brain regulation of glucose homeostasis is sexually dimorphic; however, the impact sex hormones have on specific neuronal populations within the ventromedial hypothalamic nucleus (VMN), a metabolically sensitive brain region, has yet to be
Externí odkaz:
https://doaj.org/article/0050222d83d94959abc109153180a7b8
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Hypoglycemia is a profound threat to the brain since glucose is its primary fuel. As a result, glucose sensors are widely located in the central nervous system and periphery. In this perspective we will focus on the role of hypothalamic glucose-inhib
Externí odkaz:
https://doaj.org/article/319a4ec3e36147b59ab4b9b613a73255
Autor:
Vishwendra Patel, Pallabi Sarkar, Dashiel M. Siegel, Suraj B. Teegala, Pamela R. Hirschberg, Hamad Wajid, Omar Itani, Vanessa H. Routh
Publikováno v:
Diabetes.
Perifornical hypothalamus (PFH) orexin glucose-inhibited (GI) neurons that facilitate arousal have been implicated in hypoglycemia awareness. Mice lacking orexin exhibit narcolepsy and orexin mediates the effect of the anti-narcolepsy drug, modafinil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ac21cdfd53390c036d6459f3cac11a
https://doi.org/10.2337/db22-0639
https://doi.org/10.2337/db22-0639
Autor:
Vanessa H. Routh
Publikováno v:
Sensors, Vol 10, Iss 10, Pp 9002-9025 (2010)
Neurons whose activity is regulated by glucose are found in a number of brain regions. Glucose-excited (GE) neurons increase while glucose-inhibited (GI) neurons decrease their action potential frequency as interstitial brain glucose levels increase.
Externí odkaz:
https://doaj.org/article/2da64cdb258b4be4a93804c6713af291
Autor:
Vanessa H. Routh, Gwyndolin M. Vail, Pallabi Sarkar, Suraj B. Teegala, Dashiel M. Siegel, Pamela R. Hirschberg, Stephanie M. Garcia
Publikováno v:
Journal of Neuroendocrinology. 33
Subsequent to the discovery of insulin 100 years ago, great strides have been made in understanding its function, especially in the brain. It is now clear that insulin is a critical regulator of the neuronal circuitry controlling energy balance and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88822d6e790b89701a5c1a2efd995c29
https://doi.org/10.1111/jne.12937
https://doi.org/10.1111/jne.12937
Autor:
Xavier Fioramonti, Adam Deak, Srinidhi Deshpande, Lionel Carneiro, Chunxue Zhou, Nazish Sayed, Branly Orban, Joshua R Berlin, Luc Pénicaud, Corinne Leloup, Annie Beuve, Vanessa H Routh
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68709 (2013)
Hypoglycemia is a severe side effect of intensive insulin therapy. Recurrent hypoglycemia (RH) impairs the counter-regulatory response (CRR) which restores euglycemia. During hypoglycemia, ventromedial hypothalamus (VMH) production of nitric oxide (N
Externí odkaz:
https://doaj.org/article/a5bd273ea0b94bd5b7ddbdc809114a25
Autor:
Vanessa H. Routh, Pamela R. Hirschberg, Stephanie M. Garcia, Dashiel M. Siegel, Pallabi Sarkar, Gwyndolin M. Vail, Suraj B. Teegala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86eb6704dba48aaf8cd870ef4ff49206
https://doi.org/10.1111/jne.12937/v2/response1
https://doi.org/10.1111/jne.12937/v2/response1
Autor:
Chunxue Zhou, Vanessa H. Routh
Publikováno v:
Diabetes
We previously showed that the glutathione precursor, N-acetylcysteine (NAC), prevented hypoglycemia-associated autonomic failure (HAAF) and impaired activation of ventromedial hypothalamus (VMH) glucose-inhibited (GI) neurons by low glucose after rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053c7507d3eb5ca50dfee65b4e3a57d8
http://europepmc.org/articles/PMC5741147
http://europepmc.org/articles/PMC5741147
Autor:
Preeti Kishore, Shiksha Sharma, Eric Lontchi Yimagou, Vanessa H. Routh, Norica Tomuta, Kehao Zhang, Meredith Hawkins, Sandra Aleksic, Sylvia Kehlenbrink, Daniel T. Stein
Publikováno v:
Diabetes. 68
Brain signals are integral to maintaining normal glucose homeostasis. Activation of hypothalamic KATP channels with diazoxide (DZX) reduces EGP in nondiabetic rodents and humans, but not in T2D. High fatty acids levels, typical of T2D, can increase e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5adef02028af9222d46110af2d6c9c5c
https://doi.org/10.2337/db19-1799-p
https://doi.org/10.2337/db19-1799-p