Zobrazeno 1 - 10
of 338
pro vyhledávání: '"H. Rook"'
Autor:
Brian Poligone, Carolina V. Alexander-Savino, Ellen J. Kim, Aaron R. Mangold, Jennifer Desimone, Henry K. Wong, Adam T. Rumage, Oreola Donini, Andrea Haulenbeek, Christopher J. Schaber, Richard Straube, Christopher Pullion, Alain H. Rook
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Cutaneous T-cell lymphoma (CTCL) is a rare type of non-Hodgkin lymphoma of the skin, where at later stages skin-homing malignant T-cells affect lymph nodes, blood, and visceral organs. Even though early CTCL does not affect survival, it can progress
Externí odkaz:
https://doaj.org/article/bdbb6ac6b01d45d1bb769e22f7ae38c8
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 11, Iss , Pp 100255- (2023)
Interferons are widely expressed cytokines that possess potent anti-viral and anti-tumor activity. As therapeutic agents, interferons have proven useful in treating assorted cancers, chronic infections, and autoimmune disease. However, interferon the
Externí odkaz:
https://doaj.org/article/7e53a195987345338f4fbd31338235b2
Autor:
Lauren C. Shaw, Mathilde Poussin, Alba Rodriguez-Garcia, Joshua Eggold, Nicholas G. Minutolo, Jie Wang, Alain H. Rook, Stephen J. Schuster, Daniel J. Powell
Publikováno v:
Blood Advances. 7:1885-1898
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies associated with poor prognosis due to ineffective treatment options and high rates of relapse. The success of chimeric antigen receptor T-cell (CART) therapy for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51107c32bde30672ad0417d7768c88db
https://doi.org/10.1182/bloodadvances.2022008798
https://doi.org/10.1182/bloodadvances.2022008798
Autor:
Christopher Morehouse, Rakesh Kumar, Antoine Hollebecque, Aurélien Marabelle, Zachary A Cooper, Joshua Brody, Farzana Walcott, Charles Ferte, Shilpa Gupta, David S Hong, Lillian Siu, Antonio Jimeno, Pamela Munster, Juneko Grilley-Olson, Alain H Rook, Rebecca K S Wong, James W Welsh, Yuling Wu, Oday Hamid
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background MEDI9197 is an intratumorally administered toll-like receptor 7 and 8 agonist. In mice, MEDI9197 modulated antitumor immune responses, inhibited tumor growth and increased survival. This first-time-in-human, phase 1 study evaluated MEDI919
Externí odkaz:
https://doaj.org/article/1cea92e961774c018a7c1b71c547d92b
Autor:
Christina A. Guzzo, Neha N. Jariwala, Paul L. Haun, Kelly M. MacArthur, Christen M. Mowad, Elisabeth G. Richard, Joseph P. Holton, Alain H. Rook
Publikováno v:
Acta Dermato-Venereologica, Vol 100, Iss 13, p adv00187 (2020)
Folliculotropic mycosis fungoides is a variant of cutaneous T-cell lymphoma characterized as having a folliculocentric infiltrate of malignant T cells along with a worse prognosis in comparison to the epidermotropic variants. Patients with advanced f
Externí odkaz:
https://doaj.org/article/ef6eab9e72984f4aacd1f36d4f4ed811
Publikováno v:
Southern African Journal of Critical Care, Vol 33, Iss 1, Pp 8-11 (2017)
Background. For many reasons, the invasive measurement of systolic and diastolic blood pressure should be accurate. Accuracy is determined, in part, by the damping characteristics of the arterial catheter blood pressure monitoring system. Objectives
Externí odkaz:
https://doaj.org/article/95e41c011d924cdb954a09e6dddf192e
Autor:
Ellen J. Kim, Aaron R. Mangold, Jennifer A. DeSimone, Henry K. Wong, Lucia Seminario-Vidal, Joan Guitart, James Appel, Larisa Geskin, Edward Lain, Neil J. Korman, Nathalie Zeitouni, Neda Nikbakht, Kenneth Dawes, Oleg Akilov, Joi Carter, Michi Shinohara, Timothy M. Kuzel, Warren Piette, Neal Bhatia, Amy Musiek, David Pariser, Youn H. Kim, Dirk Elston, Erin Boh, Madeleine Duvic, Auris Huen, Theresa Pacheco, Jeffrey P. Zwerner, Seung Tae Lee, Michael Girardi, Christiane Querfeld, Kimberly Bohjanen, Elise Olsen, Gary S. Wood, Adam Rumage, Oreola Donini, Andrea Haulenbeek, Christopher J. Schaber, Richard Straube, Christopher Pullion, Alain H. Rook, Brian Poligone
Publikováno v:
JAMA dermatology. 158(9)
ImportanceGiven that mycosis fungoides−cutaneous T-cell lymphoma (MF/CTCL) is chronic, there is a need for additional therapies with minimal short- and long-term adverse effects. Topical synthetic hypericin ointment, 0.25%, activated with visible l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324e52e72fb4252fdfaff9693ac02e54
https://pubmed.ncbi.nlm.nih.gov/35857290
https://pubmed.ncbi.nlm.nih.gov/35857290
Autor:
Keisuke Watanabe, M. Angela Aznar, Shunichiro Kuramitsu, Mikko Siurala, Tong Da, Sangya Agarwal, Decheng Song, John Scholler, Antonia Rotolo, Avery D Posey, Alain H Rook, Paul L. Haun, Marco Ruella, Regina M. Young, Carl H June
Publikováno v:
Blood Advances.
A challenge when targeting T cell lymphoma with chimeric antigen receptor (CAR) T cell therapy is that target antigens are often shared between T cells and tumor cells, resulting in fratricide between CAR T cells and on-target cytotoxicity on normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3790c43bc93982d0d2905e9ec0074f91
https://doi.org/10.1182/bloodadvances.2022008327
https://doi.org/10.1182/bloodadvances.2022008327
Autor:
Wolfgang Weninger, Alain H. Rook, Maria Wysocka, Teresa Valero, Lai Guan Ng, Stephen K. Richardson, Christoph Hoeller
Supplementary Video 1A from In vivo Imaging of Cutaneous T-Cell Lymphoma Migration to the Skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0338d9a3cfdf096b3d943fe3138f19
https://doi.org/10.1158/0008-5472.22381089
https://doi.org/10.1158/0008-5472.22381089
Autor:
Wolfgang Weninger, Alain H. Rook, Maria Wysocka, Teresa Valero, Lai Guan Ng, Stephen K. Richardson, Christoph Hoeller
Cutaneous T-cell lymphoma (CTCL) is characterized by the accumulation of malignant CD4+ T cells in the skin. Although the expression of adhesion molecules and chemokine receptors on CTCL cells has been studied extensively on ex vivo isolated cells, v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51632ae3eb6394613ba29d2de4cdc73
https://doi.org/10.1158/0008-5472.c.6499752.v1
https://doi.org/10.1158/0008-5472.c.6499752.v1