Zobrazeno 1 - 10
of 215
pro vyhledávání: '"H. Robert Horvitz"'
Autor:
Constanza Ahumada-Marchant, Carlos Ancatén-Gonzalez, Henny Haensgen, Bastian Brauer, Nicolas Merino-Veliz, Rita Droste, Felipe Arancibia, H. Robert Horvitz, Martha Constantine-Paton, Gloria Arriagada, Andrés E. Chávez, Fernando J. Bustos
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background The VPS50 protein functions in synaptic and dense core vesicle acidification, and perturbations of VPS50 function produce behavioral changes in Caenorhabditis elegans. Patients with mutations in VPS50 show severe developmental del
Externí odkaz:
https://doaj.org/article/ad30b723d8124e138da330532a3f6dbd
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract How cells regulate gene expression in a precise spatiotemporal manner during organismal development is a fundamental question in biology. Although the role of transcriptional condensates in gene regulation has been established, little is kno
Externí odkaz:
https://doaj.org/article/e15ca82db36c494f82a5916eaca4ed2b
Autor:
Jesse Cohn, Vivek Dwivedi, Giulio Valperga, Nicole Zarate, Mario de Bono, H. Robert Horvitz, Jonathan T. Pierce
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 11, Pp 3703-3714 (2019)
The BH3-only family of proteins is key for initiating apoptosis in a variety of contexts, and may also contribute to non-apoptotic cellular processes. Historically, the nematode Caenorhabditis elegans has provided a powerful system for studying and i
Externí odkaz:
https://doaj.org/article/ed511ddb50544658843df7ea6bd548d8
Autor:
Nicholas O. Burton, Vivek K. Dwivedi, Kirk B. Burkhart, Rebecca E. W. Kaplan, L. Ryan Baugh, H. Robert Horvitz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Reduced insulin-like signaling is required for C. elegans response to many environmental stressors, but how distinct outcomes are achieved is unknown. The authors show that the cytosolic sulfotransferase SSU-1 controls neurohormonal signaling via NHR
Externí odkaz:
https://doaj.org/article/271b5981c06947da9c73c1694ff3a2a9
Autor:
Michael E Hurwitz, Pamela J Vanderzalm, Laird Bloom, Julia Goldman, Gian Garriga, H. Robert Horvitz
Publikováno v:
PLoS Biology, Vol 7, Iss 6 (2009)
Externí odkaz:
https://doaj.org/article/e3c8f80c93e647889485a137a2d96ae4
Autor:
H. Robert Horvitz
Publikováno v:
The Scientific World Journal, Vol 1, Pp 137-137 (2001)
Externí odkaz:
https://doaj.org/article/f439cec4e407438f80a3bd094201cff3
Publikováno v:
eLife, Vol 11 (2022)
Cell identity is characterized by a distinct combination of gene expression, cell morphology, and cellular function established as progenitor cells divide and differentiate. Following establishment, cell identities can be unstable and require active
Externí odkaz:
https://doaj.org/article/d0f22d1bc5e548f394b11541888021a9
Publikováno v:
eLife, Vol 10 (2021)
Neural control of muscle function is fundamental to animal behavior. Many muscles can generate multiple distinct behaviors. Nonetheless, individual muscle cells are generally regarded as the smallest units of motor control. We report that muscle cell
Externí odkaz:
https://doaj.org/article/e90450d89556409c9b4b1d013f699537
Autor:
Corinne L Pender, H Robert Horvitz
Publikováno v:
eLife, Vol 7 (2018)
The HIF (hypoxia-inducible factor) transcription factor is the master regulator of the metazoan response to chronic hypoxia. In addition to promoting adaptations to low oxygen, HIF drives cytoprotective mechanisms in response to stresses and modulate
Externí odkaz:
https://doaj.org/article/04d0095ebddd4d83b9b368880c83a5a6
Autor:
Carlos Pardo-Pastor, Daniel P. Denning, Nolan Tucker, Vivek K. Dwivedi, Rita Droste, Jody Rosenblatt, Ji Na Kong, H. Robert Horvitz
Publikováno v:
Nature. 593:591-596
Cell extrusion is a mechanism of cell elimination that is used by organisms as diverse as sponges, nematodes, insects and mammals1–3. During extrusion, a cell detaches from a layer of surrounding cells while maintaining the continuity of that layer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::741f4468070403165f39c16f275b5719
https://doi.org/10.1038/s41586-021-03526-y
https://doi.org/10.1038/s41586-021-03526-y