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Akademický článek
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Publikováno v:
Collection of Czechoslovak Chemical Communications. 67:336-352
Two ways are shown to transform cardioactive cardenolides into cardenamides [17β-(5-oxo-2,5-dihydropyrrol-3-yl)-5β,14β-androstane derivatives], and their derivatives by replacement of their ring oxygen by N-R. Cardioactivity is strongly decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc302df12a4b93286e523f5c21be1758
https://doi.org/10.1135/cccc20020336
https://doi.org/10.1135/cccc20020336
Autor:
Rudolf Megges, Rudolf Schön, Kurt R. H. Repke, Horst Büchting, Bernd Undeutsch, Jürgen Weiland
Publikováno v:
Steroids. 63:464-469
To improve the weak inhibitory effect of 3-oxo-17 alpha-pregna-4,6-diene-21,17-carbolactone (canrenone, II) on Na+/K(+)-ATPase activity in human heart muscle, we have investigated the impact of hydrogenation, reduction, glycosidation, and the introdu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e845fa75653dcc589ebb924a576940b5
https://doi.org/10.1016/s0039-128x(98)00049-x
https://doi.org/10.1016/s0039-128x(98)00049-x
Publikováno v:
Journal of Enzyme Inhibition. 12:53-58
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478bbb1d9fe5eedd630948b34a2b639f
https://doi.org/10.3109/14756369709027663
https://doi.org/10.3109/14756369709027663
Publikováno v:
Angewandte Chemie International Edition in English. 34:282-294
“The following remarks consist partially of matter of fact, and partially of opinion. The former will be permanent; the latter must vary with the detection of error, or the improvement of knowledge. I hazard them with diffidence, and hope they will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cc5ef8adb5c148c2d59302360979862
https://doi.org/10.1002/anie.199502821
https://doi.org/10.1002/anie.199502821
Publikováno v:
Angewandte Chemie. 107:308-321
Der Arzt William Withering fuhrte 1785 mit seinem Buch „An Account of the Foxglove and some of its Medical Uses” Praparate aus Digitalisblattern in die Therapie der Wassersucht (des Herzversagens) ein und erklarte: „The following remarks consis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250a988d769b493956acec43b0efd97a
https://doi.org/10.1002/ange.19951070305
https://doi.org/10.1002/ange.19951070305
Publikováno v:
European Journal of Medicinal Chemistry. 30:763-767
Summary Acetates of gomphogenin and gomphoside have been synthesized and their structures established by NMR measurements, optical rotation, mass and infrared spectrometry. The kinetic and equilibrium parameters of the inhibitory interaction of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1492b8d2f8005c5620c1c4536f16d07
https://doi.org/10.1016/0223-5234(96)88295-x
https://doi.org/10.1016/0223-5234(96)88295-x
Autor:
Kurt R. H. Repke, Rudolf Schön
Publikováno v:
Biological Reviews. 69:119-145
The original aim of the review has been to probe into the validity of the paradigm on the high energy-carrier function of ATP. It seemed to be called into question on the basis of findings with H(+)-transporting ATP synthase suggesting the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd35c4162ec9d4ecbb4aea013a30a311
https://doi.org/10.1111/j.1469-185x.1994.tb01503.x
https://doi.org/10.1111/j.1469-185x.1994.tb01503.x
Publikováno v:
Journal of Enzyme Inhibition. 8:197-205
The glycosidic moiety plays an important role in the pharmacokinetic and pharmacodynamic behaviour of cardiac glycosides like digitoxin and digoxin. Their tridigitoxoside side chain becomes slowly removed in the animal body and hence delays the inact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788d865984b46b59669d88d11ffd1d89
https://doi.org/10.3109/14756369409020201
https://doi.org/10.3109/14756369409020201