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pro vyhledávání: '"H. Rehm"'
Akademický článek
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Publikováno v:
European Physical Journal C: Particles and Fields, Vol 84, Iss 9, Pp 1-16 (2024)
Abstract This study investigates the particle’s geodesic motion and accretion around the spherically symmetric Reissner–Nordström black hole coupled with a nonlinear electrodynamics field. The formation of the disc-like structure in the accretio
Externí odkaz:
https://doaj.org/article/76dc0b66b3da4752bfcf9d88d42a6a7f
Akademický článek
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Autor:
Hidde L. Ploegh, Yushu J. Xie, Novalia Pishesha, William Pinney, Weiyi Ma, Fabian B. H. Rehm, Thibault J. Harmand
Publikováno v:
ACS Chemical Biology. 16:1201-1207
Red blood cells (RBCs) can serve as vascular carriers for drugs, proteins, peptides, and nanoparticles. Human RBCs remain in the circulation for ∼120 days, are biocompatible, and are immunologically largely inert. RBCs are cleared by the reticuloen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9070a6a0635908ca40a56a86e036b7
https://doi.org/10.1021/acschembio.1c00216
https://doi.org/10.1021/acschembio.1c00216
Autor:
Fabian B. H. Rehm, Simon J. de Veer, Linda H.L. Lua, Shyn Ric Tang, Yan Zhou, Conan K. Wang, Thomas Durek, David J. Craik, Junqiao Du, Kuok Yap, Jing Xie
Publikováno v:
Nature Protocols. 16:1740-1760
Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing cyclic peptide precursors in Pichia pastoris that undergo in vitro enzymatic maturation into cyclic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78359db5bb7f40ba35d5152773d88949
https://doi.org/10.1038/s41596-020-00483-0
https://doi.org/10.1038/s41596-020-00483-0
Publikováno v:
Angewandte Chemie. 133:4050-4054
The use of enzymes for the site-specific modification of proteins/peptides has become a highly accessible, widespread approach to study protein/peptide functions or to generate therapeutic conjugates. Asparaginyl endopeptidases (AEPs) that preferenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a680ba6a243de1e150678c82d0710f8
https://doi.org/10.1002/ange.202013584
https://doi.org/10.1002/ange.202013584
Autor:
Thomas H. Rehm
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Photochemical transformations of molecular building blocks have become an important and widely recognized research field in the past decade. Detailed and deep understanding of novel photochemical catalysts and reaction concepts with visible light as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c96e35c78d4fcff4952b79775beac0f
https://doi.org/10.1002/chem.202000381
https://doi.org/10.1002/chem.202000381
Autor:
Quentin Kaas, Edward K. Gilding, David J. Craik, Fong Yang Looi, Lai Yue Chan, Thomas Durek, Kuok Yap, Junqiao Du, Aaron G. Poth, Fabian B. H. Rehm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs from Momordica cochinchinensis and biochemically characterize MCoAEP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e744473c7211021896367957acb68339
https://doaj.org/article/2374d960c8e2417095bdec822494ebdd
https://doaj.org/article/2374d960c8e2417095bdec822494ebdd
Autor:
David J. Craik, Fabian B. H. Rehm, Anuja R. Bony, Kuok Yap, Shyn Ric Tang, Simon J. de Veer, Junqiao Du, Fong Yang Looi, Conan K. Wang, David J. Adams, Jing Xie, Linda H.L. Lua, Lai Yue Chan, Thomas Durek
Publikováno v:
Green Chemistry. 22:5002-5016
Macrocyclic, disulfide-rich peptides have found widespread applications in drug design and development. Current peptide production strategies rely heavily on solid phase peptide synthesis (SPPS) requiring large amounts of hazardous/toxic reagents and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01a7383e9423cf392e3c3b6663a8b56b
https://doi.org/10.1039/d0gc01366h
https://doi.org/10.1039/d0gc01366h
Autor:
Choi Yi Li, Fabian B. H. Rehm, Kuok Yap, Christina N. Zdenek, Maxim D. Harding, Bryan G. Fry, Thomas Durek, David J. Craik, Simon J. de Veer
Publikováno v:
Angewandte Chemie (International ed. in English). 61(19)
Knottins are topologically complex peptides that are stabilised by a cystine knot and have exceptionally diverse functions, including protease inhibition. However, approaches for tuning their activity in situ are limited. Here, we demonstrate separat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a487a2ad692a4b8f125ee580aecc44f
https://pubmed.ncbi.nlm.nih.gov/35224831
https://pubmed.ncbi.nlm.nih.gov/35224831