Zobrazeno 1 - 10 of 138 pro vyhledávání: '"H. R. Withers"'
1
Use of the LQ model with large fraction sizes results in underestimation of isoeffect doses
Autor: Mark K. Transtrum, Jessica M. Molkentine, Howard D. Thames, Kathryn A. Mason, Tommy Sheu, H. R. Withers, Thomas A. Buchholz
Publikováno v: Radiotherapy and Oncology. 109:21-25
Purpose: To test the appropriateness of the linear-quadratic (LQ) model to describe survival of jejunal crypt clonogens after split doses with variable (small 1–6 Gy, large 8–13 Gy) first dose, as a model of its appropriateness for both small and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f4bd86cecada95dcbb387ce0737a5b
https://doi.org/10.1016/j.radonc.2013.08.027
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6
Time factor and treatment strategies in subclinical disease
Autor: Rafał Suwiński, H. R. Withers
Publikováno v: International Journal of Radiation Biology. 79:495-502
Rational biological development of treatment strategies for subclinical metastases has lagged behind such efforts with primary cancers: most adjuvant therapies for subclinical disease have been developed empirically, based on clinical observation. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a859d7b08a35475f6b5a3496dad91ed
https://doi.org/10.1080/09553000310001596986
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7
The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems
Autor: Malachi Tolman, Howard D. Thames, Andrew White, H. R. Withers, Mark K. Transtrum, Kathy A. Mason
Publikováno v: PLoS Computational Biology, Vol 12, Iss 12, p e1005227 (2016)
PLoS Computational Biology
We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c886381f79094323cef2290853910b
https://doi.org/10.1371/journal.pcbi.1005227
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9
A non-parametric method of reconstructing single-dose survival curves from multi-fraction experiments
Autor: Kathryn A. Mason, Vijaya Vegesna, Jeremy M. G. Taylor, H. R. Withers
Publikováno v: International Journal of Radiation Biology. 74:583-593
A method of estimating the single-dose curve from designed multifraction experiments is described and applied to three datasets.The method, which is non-parametric and based on standard statistical regression techniques, can be used for functional en
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9056f30a045a9267bcbbeff888357ca6
https://doi.org/10.1080/095530098141168
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10
Effect of low-dose radiation on mouse dermal tissue using wound strength as an endpoint
Autor: H. R. Withers, Jeremy M. G. Taylor, William H. McBride, Vijaya Vegesna
Publikováno v: International Journal of Radiation Biology. 72:645-652
Purpose: To investigate the existence of enhanced sensitivity of dermal tissue to low radiation doses in the range of 0.1 Gy to 4 Gy/fraction. Materials and methods: Top-up technique of giving higher radiation doses to skin alone from 150 kvp X-rays
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ed1807ab52f5cd4fb9179984860511
https://doi.org/10.1080/095530097142799
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