Zobrazeno 1 - 10
of 67
pro vyhledávání: '"H. R. Morse"'
Publikováno v:
Mutagenesis. 30:851-880
Although gene expression analysis using real-time quan- titative reverse transcription-polymerase chain reaction (RT-qPCR) is an accurate method to evaluate cell activi- ties and phenotypes, the reliability of the analysis depends on the selection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8554b0663f84442943a0018ffb2f16b
https://doi.org/10.1093/mutage/gev074
https://doi.org/10.1093/mutage/gev074
Autor:
Christine Cox, Jennifer E. May, Craig Donaldson, Jinsheng Xu, K. Page, H. R. Morse, Sarah A. Wexler, M. Soh
Publikováno v:
Mutagenesis. 29:79-96
Cytosine arabinoside (ara-C) is a key chemotherapy drug used to treat acute myeloid leukaemia (AML), however, ap- proximately 30% of patients do not respond to this therapy. 92 An evaluative assay to determine resistance/sensitivity to ara- C prior t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac3a6d80aff7bfdd92baca0fea702b5
https://doi.org/10.1093/mutage/get060
https://doi.org/10.1093/mutage/get060
Autor:
M. R. Salehan, H. R. Morse
Publikováno v:
British Journal of Biomedical Science. 70:31-40
A significant barrier to effective cancer therapy is the development of resistance to the drugs utilised. Standard chemotherapeutic regimens typically contain genotoxic agents, designed to damage DNA of existing tumour cells as well as prevent the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6debf2be3592704d613b04b92b007f17
https://doi.org/10.1080/09674845.2013.11669927
https://doi.org/10.1080/09674845.2013.11669927
Publikováno v:
British Journal of Biomedical Science. 66
Prior to introduction to the clinic, pharmaceuticals must undergo rigorous toxicity testing to ensure their safety. Traditionally, this has been achieved using in vivo animal models. However, besides ethical reasons, there is a continual drive to red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b76dc10988fdd7191cea0e132c587de
Publikováno v:
European Journal of Immunogenetics. 26:135-223
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffeb903db3f56a6aef8e9d3fd486b967
https://doi.org/10.1046/j.1365-2370.1999.00143.x-i2
https://doi.org/10.1046/j.1365-2370.1999.00143.x-i2
Publikováno v:
European Journal of Immunogenetics. 25:83-265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e88d05725f1a0676816db930d4547e
https://doi.org/10.1046/j.1365-2370.1998.00079.x
https://doi.org/10.1046/j.1365-2370.1998.00079.x
Publikováno v:
Genes and immunity. 1(3)
We have identified a single nucleotide polymorphism in the 5' region of the human interleukin-1 receptor type I (IL-1RI) gene, a C-->A transversion at position 52 in exon 1C (GenBank accession number AF172151) which creates a Bsr BI restriction endon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f913fcf3906bf9f2a48cf1ae1baa773a
https://pubmed.ncbi.nlm.nih.gov/11196719
https://pubmed.ncbi.nlm.nih.gov/11196719
Autor:
Despina Sitara, O. O. Olomolaiye, LJ Keen, Jeffrey L. Bidwell, H. R. Morse, Christopher J. Elson, C. I. Westacott, N. A. P. Wood
Publikováno v:
Genes and immunity. 1(2)
We have identified two novel single nucleotide polymorphisms in the 5' region of the human IL-1RI gene: (1) A-->G at position 52 in intron 1B (GenBank accession number AF146426), which creates an Mspl restriction endonuclease site. Allele frequencies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356303ed2395cf9d2d51825f83fcae93
https://pubmed.ncbi.nlm.nih.gov/11196665
https://pubmed.ncbi.nlm.nih.gov/11196665
Publikováno v:
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics. 26(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28e8e7c0b2bce395a5831c4865fee062
https://pubmed.ncbi.nlm.nih.gov/10553506
https://pubmed.ncbi.nlm.nih.gov/10553506
Publikováno v:
Cytokine. 11(10)
We describe the construction and use of 7 induced heteroduplex generators, reagents for the rapid and unequivocal genotyping of nucleotide sequence polymorphism in TNF-alpha, IL-1beta, IL-6 and IL-10. Polymorphisms detected are those previously assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fac2928ea5996edc71e8b1e6b96b7a8
https://pubmed.ncbi.nlm.nih.gov/10525318
https://pubmed.ncbi.nlm.nih.gov/10525318