Zobrazeno 1 - 10
of 118
pro vyhledávání: '"H. Pelicano"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2315-2320
Two new 5′-phosphorylated derivatives of 3′-azido-3′-deoxythymidine (AZT), namely α,β;β,γ-bis (methylene) AZT-5′-triphosphate 1 and α,β-propylene AZT 5′-diphosphate 2 , were synthesized. When evaluated for their inhibitory effects on
Autor:
L. Bellon, H. Pelicano, Georges Maury, J. Deydier, C. Leydier, J. L. Barascut, M. A. El Alaoui, J.‐L. Imbach
Publikováno v:
Nucleosides and Nucleotides. 13:2035-2050
A new synthesis of 4′-thioribonucleosides is presented together with the enzymatic evaluation of the adenosine analogues with respect to adenosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor 7 was obtained in good yield from D-ribose
Autor:
J. Deydier, L. Bellon, H. Pelicano, J.‐L. Imbach, M. A. El Alaoui, C. Leydier, Georges Maury, J. L. Barascut
Publikováno v:
ChemInform. 26
A new synthesis of 4′-thioribonucleosides is presented together with the enzymatic evaluation of the adenosine analogues with respect to adenosine kinase. The 4-thio-D-ribofuranosyl carbohydrate precursor 7 was obtained in good yield from D-ribose
Autor:
H. Pelicano, Jean Louis Imbach, André Kirn, Jean-Luc Girardet, Christian Périgaud, S. Benzaria, Anne-Marie Aubertin, Gilles Gosselin, Georges Maury
Publikováno v:
ChemInform. 26
It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phospho
Autor:
G. Obert, S. Benzaria, H. Pelicano, Georges Maury, André Kirn, Anne-Marie Aubertin, J.‐L. Imbach, Gilles Gosselin
Publikováno v:
ChemInform. 26
The synthesis, and stability in different media of new PMEA prodrugs, with S-acylthioethyl (SATE) as enzyme-labile phosphonate protecting groups, are described in comparison with the already known Bis(POM)- and Bis(DTE)PMEA.
Publikováno v:
ChemInform. 27
Two new 5′-phosphorylated derivatives of 3′-azido-3′-deoxythymidine (AZT), namely α,β;β,γ-bis (methylene) AZT-5′-triphosphate 1 and α,β-propylene AZT 5′-diphosphate 2 , were synthesized. When evaluated for their inhibitory effects on
Autor:
G. Obert, Georges Maury, Richard Johnson, Anne Marie Aubertin, Gilles Gosselin, S. Benzaria, H. Pelicano, Jean Louis Imbach
Publikováno v:
ChemInform. 28
A new series of hitherto unknown 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) phosphonodiester derivatives incorporating carboxyesterase-labile S-acyl-2-thioethyl (SATE) moieties as transient phosphonate-protecting groups was prepared in an attempt to
Autor:
Georges Maury, Jean Louis Imbach, Christian Périgaud, André Kirn, H. Pelicano, S. Benzaria, Anne-Marie Aubertin, Jean-Luc Girardet, Gilles Gosselin
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:789-791
It is shown that ddA bis(SATE)phosphotriesters have potent anti-HIV activity in cell culture. Thus, compared with the parent nucleoside, a decrease of 3 or 4 orders of magnitude was observed in the EC50 values for the bis(S-acetyl-2-thioethyl)phospho
Autor:
André Kirn, S. Benzaria, Georges Maury, J.‐L. Imbach, Anne-Marie Aubertin, Gilles Gosselin, H. Pelicano, G. Obert
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 14:563-565
The synthesis, and stability in different media of new PMEA prodrugs, with S-acylthioethyl (SATE) as enzyme-labile phosphonate protecting groups, are described in comparison with the already known Bis(POM)- and Bis(DTE)PMEA.
Publikováno v:
Cancer research. 61(24)
Therapeutic nucleoside analogues such as ara-C, gemcitabine, and fludarabine exert their cytotoxic activity against cancer cells mainly by incorporation into DNA and disruption of further DNA synthesis, resulting in the triggering of apoptosis. Howev