Zobrazeno 1 - 10
of 512
pro vyhledávání: '"H. Pearl"'
Autor:
Matthew Day, Bilal Tetik, Milena Parlak, Yasser Almeida-Hernández, Markus Räschle, Farnusch Kaschani, Heike Siegert, Anika Marko, Elsa Sanchez-Garcia, Markus Kaiser, Isabel A. Barker, Laurence H. Pearl, Antony W. Oliver, Dominik Boos
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Activation of the replicative Mcm2-7 helicase by loading GINS and Cdc45 is crucial for replication origin firing, and as such for faithful genetic inheritance. Our biochemical and structural studies demonstrate that the helicase activator GI
Externí odkaz:
https://doaj.org/article/91e316aec1f548cab215f4d414dc36db
Autor:
Jasmeen Oberoi, Xavi Aran Guiu, Emily A. Outwin, Pascale Schellenberger, Theodoros I. Roumeliotis, Jyoti S. Choudhary, Laurence H. Pearl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Binding to HSP90-CDC37 is essential for the activity of many protein kinases, but its function is unclear. Here, the authors show that HSP90-CDC37 provides a structural platform for the phosphatase PP5 to dephosphorylate a bound kinase, ‘factory re
Externí odkaz:
https://doaj.org/article/ca5b7d09a84441d8a9ec619dd2f19cdf
Autor:
Angel Rivera-Calzada, Raquel Arribas-Bosacoma, Alba Ruiz-Ramos, Paloma Escudero-Bravo, Jasminka Boskovic, Rafael Fernandez-Leiro, Antony W. Oliver, Laurence H. Pearl, Oscar Llorca
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Vaccinia virus expresses two proteins that interfere with the host immune response. Here, authors provide the structural basis for this viral defence mechanism, conserved in other poxviruses such as the causatives agents of smallpox and monkeypox.
Externí odkaz:
https://doaj.org/article/8166a1fa6c9d47a0afe20872a86f6ed5
Autor:
Jason H. Pearl
Historians of the Enlightenment have studied the period's substantial advances in world cartography, as well as the decline of utopia imagined in geographic terms. Literary critics, meanwhile, have assessed the emerging novel's realism and in particu
Autor:
Apurva T. Prabhakar, Claire D. James, Dipon Das, Raymonde Otoa, Matthew Day, John Burgner, Christian T. Fontan, Xu Wang, Sarah H. Glass, Andreas Wieland, Mary M. Donaldson, Molly L. Bristol, Renfeng Li, Anthony W. Oliver, Laurence H. Pearl, Brian O. Smith, Iain M. Morgan
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Human papillomaviruses are causative agents in around 5% of all cancers, with no specific antiviral therapeutics available for treating infections or resultant cancers. In this report, we demonstrate that phosphorylation of HPV16 E2 by CK2 promotes f
Externí odkaz:
https://doaj.org/article/198e33f511a84547b225bf38fd4332b1
Autor:
Meghan H. Pearl, Jonathan Grotts, Maura Rossetti, Qiuheng Zhang, David W. Gjertson, Patricia Weng, David Elashoff, Elaine F. Reed, Eileen Tsai Chambers
Publikováno v:
Kidney International Reports, Vol 4, Iss 4, Pp 541-550 (2019)
Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non–human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific a
Externí odkaz:
https://doaj.org/article/d94308070b74487c9dfecdaed9608c27
Autor:
Xiangrong Chen, Yusuf I Ali, Charlotte EL Fisher, Raquel Arribas-Bosacoma, Mohan B Rajasekaran, Gareth Williams, Sarah Walker, Jessica R Booth, Jessica JR Hudson, S Mark Roe, Laurence H Pearl, Simon E Ward, Frances MG Pearl, Antony W Oliver
Publikováno v:
eLife, Vol 10 (2021)
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA dam
Externí odkaz:
https://doaj.org/article/9ec1a9ebd4b44f678f41f09602610beb
Autor:
Fabrizio Martino, Mohinder Pal, Hugo Muñoz-Hernández, Carlos F. Rodríguez, Rafael Núñez-Ramírez, David Gil-Carton, Gianluca Degliesposti, J. Mark Skehel, S. Mark Roe, Chrisostomos Prodromou, Laurence H. Pearl, Oscar Llorca
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The R2TP/PFDL co-chaperone facilitates assembly of RNA polymerase II and PI3-kinase-like kinases such as mTOR by a so far unknown mechanism. Here authors provide the cryo-EM structure of human R2TP, which shows how RPAP3 serves as a flexible platform
Externí odkaz:
https://doaj.org/article/817fe8022b364f6ab87e9c148af5e6d8
Autor:
Stephen T. Hallett, Martyna W. Pastok, R. Marc L. Morgan, Anita Wittner, Katie L.I.M. Blundell, Ildiko Felletar, Stephen R. Wedge, Chrisostomos Prodromou, Martin E.M. Noble, Laurence H. Pearl, Jane A. Endicott
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1386-1398 (2017)
Summary: Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system. Like other Hsp90
Externí odkaz:
https://doaj.org/article/47f3367cf8e14eb7a9f180a5866f49b6
Publikováno v:
Cell Reports, Vol 19, Iss 12, Pp 2515-2528 (2017)
Summary: Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases. This provides the rationale for HSP90 inhibitors as cancer therap
Externí odkaz:
https://doaj.org/article/83442f5cda55424c8b865f241ebc40b4