Zobrazeno 1 - 10
of 29
pro vyhledávání: '"H. Paul Voorheis"'
Autor:
Orla Hanrahan, Helena Webb, Robert O'Byrne, Elaine Brabazon, Achim Treumann, Jack D Sunter, Mark Carrington, H Paul Voorheis
Publikováno v:
PLoS Pathogens, Vol 5, Iss 6, p e1000468 (2009)
Bloodstream forms of Trypanosoma brucei contain a glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC) that cleaves the GPI-anchor of the variable surface glycoprotein (VSG). Its location in trypanosomes has been controversial. Here, using
Externí odkaz:
https://doaj.org/article/bc4fdc332f5d4bddbd0b037ccf2aa5d3
Autor:
Siddhartha Sen, H. Paul Voorheis
Publikováno v:
Journal of Theoretical Biology. 363:169-187
The mechanism of protein folding during early stages of the process has three determinants. First, moving water molecules obey the rules of low Reynolds number physics without an inertial component. Molecular movement is instantaneous and size insens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588d7c43780e1f8b1ff6033a96f480c1
https://doi.org/10.1016/j.jtbi.2014.07.025
https://doi.org/10.1016/j.jtbi.2014.07.025
Publikováno v:
Scientific Reports
A major goal of biology is to develop a quantitative ligand-binding assay that does not involve the use of radioactivity. Existing fluorescence-based assays have a serious drawback due to fluorescence quenching that accompanies the binding of fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4916fb859b52e02f50966dbdb35456f
Autor:
Soyoung Min, Hannah Kirk, K. Hun Mok, H. Paul Voorheis, Níal P. Harte, John E. O'Brien, Yongjing Xie, Catharina Svanborg
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:1-17
Human α-lactalbumin made lethal to tumor cells (HAMLET) and its analogs are partially unfolded protein-oleic acid (OA) complexes that exhibit selective tumoricidal activity normally absent in the native protein itself. To understand the nature of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf0a970779a3717115f740990f82f1b
https://doi.org/10.1002/prot.24141
https://doi.org/10.1002/prot.24141
Autor:
Peter R. Nielsen, H. Paul Voorheis, Daniel Nietlispach, Helen R. Mott, Anasuya Chattopadhyay, Nicola G. Jones, Mark Carrington
Publikováno v:
Journal of Biological Chemistry. 280:7228-7235
The variant surface glycoprotein (VSG) of African trypanosomes has a structural role in protecting other cell surface proteins from effector molecules of the mammalian immune system and also undergoes antigenic variation necessary for a persistent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d381f32bdb707b3926d1d4aeb58fc8ab
https://doi.org/10.1074/jbc.m410787200
https://doi.org/10.1074/jbc.m410787200
Autor:
Derek P. Nolan, H. Paul Voorheis
Publikováno v:
European Journal of Biochemistry. 267:4615-4623
The plasma-membrane potential (Δψp) in bloodstream forms of Trypanosoma brucei was studied using several different radiolabelled probes: 86Rb+ and [14C]SCN− were used to report Δψp directly because they distribute in easily measured quantities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63175e6dacd9c09fced9c54234d9e09b
https://doi.org/10.1046/j.1432-1327.2000.01477.x
https://doi.org/10.1046/j.1432-1327.2000.01477.x
Publikováno v:
Journal of Parasitology. 86:56-59
Trypanosoma granulosum,a flagellate protozoon commonly found in the blood of the European eel Anguilla anguilla, was injected experimentally into uninfected eels purchased from a local farm. In order to investigate the infectivity of different stages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57da336b9801acb08400701e48b07a95
https://doi.org/10.1645/0022-3395(2000)086[0056:eiofew]2.0.co
https://doi.org/10.1645/0022-3395(2000)086[0056:eiofew]2.0.co
Autor:
Daniel J. Bridges, Harry P. de Koning, Andrew R. Pitt, H. Paul Voorheis, Kiva Brennan, Richard Burchmore, Orla Hanrahan, Pawel Herzyk
Publikováno v:
Proteomics. 8(1)
Proteome analysis by conventional approaches is biased against hydrophobic membrane proteins, many of which are also of low abundance. We have isolated plasma membrane sheets from bloodstream forms of Trypanosoma brucei by subcellular fractionation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a0c87f760c366acbcb763e4d422b44
https://pubmed.ncbi.nlm.nih.gov/18095354
https://pubmed.ncbi.nlm.nih.gov/18095354
Autor:
H. Paul Voorheis, Derek N. Nolan, Orla Hanrahan, Alison E. Adams, Padraic G. Fallon, Richard K. Porter
Publikováno v:
Biochimica et biophysica acta. 1777(2)
The aim of this study was to demonstrate the constitutive expression of mitochondrial uncoupling protein 1 (UCP 1) in pure thymocytes using laser scanning confocal microscopic imagery. To that end we probed thymocytes from UCP 1 knock-out and wild-ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::780c6f79a8ca52bfe33a0fb975227305
https://pubmed.ncbi.nlm.nih.gov/17996719
https://pubmed.ncbi.nlm.nih.gov/17996719
Autor:
Derek P. Nolan, H. Paul Voorheis
Publikováno v:
European journal of biochemistry. 267(15)
Conditions for the use of both [14C]methylamine and 5, 5-dimethyl[14C]oxa-azolidine-2,4-dione (DMO) to measure the H+ concentration of intracellular compartments of monomorphic long thin bloodstream forms of Trypanosoma brucei were established. Neith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1217c6ee388812b08e0c0627d4916bce
https://pubmed.ncbi.nlm.nih.gov/10903492
https://pubmed.ncbi.nlm.nih.gov/10903492