Zobrazeno 1 - 10
of 93
pro vyhledávání: '"H. PIECHUTA"'
Autor:
Diane Ethier, Philip Tagari, Richard Frenette, H. Piechuta, C. C. Chan, Denis Riendeau, Michel Therien, M. McAuliffe, Yves Girard, John H. Hutchinson, Christine Brideau, Stella Charleson, Thomas R. Jones, Jocelyne Guay, Serge Leger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2391-2396
This paper reports on the SAR investigation of inhibitors of 5-lipoxygenase activating protein (FLAP) based on MK-0591. Emphasis was made on modifications to the nature of the link between the indole and the quinoline moieties, to the substitution pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c254d782d281d756af3022a52f72422e
https://doi.org/10.1016/s0960-894x(99)00399-6
https://doi.org/10.1016/s0960-894x(99)00399-6
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 76:210-217
The activity of CDP-840, a novel, selective phosphodiesterase IV inhibitor was determined in a leukotriene-dependent non-human primate model of allergic asthma. Measurements of specific airway resistance (sRaw) were recorded in a dual chamber plethys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15288a7e83c3e2bc85470c1eb136b4f0
https://doi.org/10.1139/y98-030
https://doi.org/10.1139/y98-030
Autor:
T. R. Jones, M. Labelle, M. Belley, E. Champion, L. Charette, J. Evans, A. W. Ford-Hutchinson, J. -Y. Gauthier, A. Lord, P. Masson, M. McAuliffe, C. S. McFarlane, K. M. Metters, C. Pickett, H. Piechuta, C. Rochette, I. W. Rodger, N. Sawyer, R. N. Yoyng, R. Zamboni, W. M. Abraham
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 73:191-201
Montelukast sodium (Singulair™), also known as MK-0476 (1-(((1(R)-(3-(2-(7-chloro-2-quinolinyl)-(E)-ethenyl)phenyl)(3-2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropane) acetic acid sodium salt, is a potent and selective inhibitor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6921a19999723f662391309297b826b0
https://doi.org/10.1139/y95-028
https://doi.org/10.1139/y95-028
Autor:
C.B. Pickett, Thomas R. Jones, Marc Labelle, M. Belley, Robert N. Young, D.H. Patrick, Robert Zamboni, Nicole Sawyer, Anthony W. Ford-Hutchinson, Y. B. Xiang, S. G. Grossman, Nathalie Ouimet, R. Gordon, Yves Leblanc, Jacques-Yves Gauthier, C. S. Mcfarlane, H. Piechuta, Kathleen M. Metters, Daniel Guay, P. Masson, C. Rochette, M. McAuliffe, Yves Gareau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:283-288
Structure-activity studies leading to the discovery of 1 (MK-0476) are described. The initial compound of this series, 2, was a potent leukotriene D4 (LTD4) antagonist, but was also a peroxisomal enzyme inducer in the mouse. Structure-activity relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50b718bf583613b2d7f8f42c53e3227
https://doi.org/10.1016/0960-894x(95)00023-m
https://doi.org/10.1016/0960-894x(95)00023-m
Autor:
Robert Zamboni, Deborah A. Nicoll-Griffith, Thomas R. Jones, P. Masson, M. Belley, H. Piechuta, J. Yergey, Robert N. Young, Kathleen M. Metters, A. Lord, R. Gordon, C. Rochette, Karst Hoogsteen, Y. B. Xiang, M. McAuliffe, Anthony W. Ford-Hutchinson, Nicole Sawyer, C. S. Mcfarlane, Marc Labelle, E. Champion, Nathalie Ouimet, Yves Leblanc, C.B. Pickett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:463-468
The styryl quinoline thioether 5 (L-699,392) is a potent and orally active leukotriene D4 antagonist. The structure-activity studies leading to its discovery are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a7d926352711059f67e0cefce5df91c
https://doi.org/10.1016/0960-894x(94)80017-0
https://doi.org/10.1016/0960-894x(94)80017-0
Autor:
Christine Brideau, Jocelyne Guay, Thomas R. Jones, H. Piechuta, Rejean Fortin, C. S. Mcfarlane, Daniel Delorme, Jean-Pierre Falgueyret, Denis Riendeau, Pierre Hamel, Michael J. Therien, John Scheigetz, Yves Girard, Philip Tagari, John H. Hutchinson, Dwight Macdonald, D. Denis, Chi-Chung Chan
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d09012672934e3b2ea463e60566ee9a5
https://doi.org/10.1002/chin.199410177
https://doi.org/10.1002/chin.199410177
Autor:
Robert Zamboni, E. Champion, Karst Hoogsteen, Y. B. Xiang, M. Belley, M. McAuliffe, Nathalie Ouimet, R. Gordon, Kathleen M. Metters, Marc Labelle, P. Masson, C. Rochette, H. Piechuta, Anthony W. Ford-Hutchinson, A. Lord, C. S. Mcfarlane, Nicole Sawyer, Deborah A. Nicoll-Griffith, Yves Leblanc, C.B. Pickett, Thomas R. Jones, J. Yergey
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7800b682b0553402eaf50b9591cfd62
https://doi.org/10.1002/chin.199431162
https://doi.org/10.1002/chin.199431162
Autor:
M. LABELLE, M. BELLEY, Y. GAREAU, J. Y. GAUTHIER, D. GUAY, R. GORDON, S. G. GROSSMAN, T. R. JONES, Y. LEBLANC, M. MCAULIFFE, C. MCFARLANE, P. MASSON, K. M. METTERS, N. OUIMET, D. H. PATRICK, H. PIECHUTA, C. ROCHETTE, N. SAWYER, Y. B. XIANG, C. B. PICKETT, A. W. FORD-HUTCHINSON, ET AL. ET AL.
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17e5febd2b8d411d166f9eb768e860c6
https://doi.org/10.1002/chin.199527182
https://doi.org/10.1002/chin.199527182
Autor:
Yves Girard, C. S. Mcfarlane, Jillian F. Evans, Denis Riendeau, Donald W. Nicholson, H. Piechuta, Stella Charleson, Stacia Kargman, Dwight Macdonald, Karst Hoogsteen, John Scheigetz, John H. Hutchinson, Thomas R. Jones, Michael J. Therien, Jean-Pierre Falgueyret
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18432bb338fa7f5b2840a8eb597ab6ab
https://doi.org/10.1002/chin.199610195
https://doi.org/10.1002/chin.199610195
Autor:
L.Y. Choo, Stella Charleson, Petpiboon Prasit, Denis Riendeau, H. Piechuta, Jillian F. Evans, Richard G. Ball, John H. Hutchinson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1699-1702
The combination of a 5-phenylpyridine substituent and a novel, substituted thiopyrano[2,3,4-c,d]indole ring system yields a potent and selective 5-lipoxygenase inhibitor, L-689,065.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c5f17d3be1c5bfbd0eb77be673cbb4
https://doi.org/10.1016/s0960-894x(00)80459-x
https://doi.org/10.1016/s0960-894x(00)80459-x