Zobrazeno 1 - 10 of 376 pro vyhledávání: '"H. PANNEKOEK"'
2
The Suicide Substrate Reaction Between Plasminogen Activator Inhibitor 1 and Thrombin Is Regulated by the Cofactors Vitronectin and Heparin
Autor: G. Tans, Anton J. G. Horrevoets, Michael E. Nesheim, A.E. Smilde, H. Pannekoek, M van Meijer
Publikováno v: Blood. 90:1874-1882
The interaction of thrombin with plasminogen activator inhibitor 1 (PAI-1) is shown to result in the simultaneous formation of both cleaved PAI-1 and a sodium dodecyl sulfate-stable thrombin-PAI-1 complex. The kinetics of this reaction can be describ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee00c516789bb19da738a48b397aebcf
https://doi.org/10.1182/blood.v90.5.1874
Zobrazit plný text záznamu
3
Molecular Advances in Plasminogen Activator Inhibitor 1 Interaction with Thrombin and Tissue-Type Plasminogen Activator
Autor: A.Allart Stoop, Anton J. G. Horrevoets, M van Meijer, H. Pannekoek
Publikováno v: Trends in cardiovascular medicine, 7(2), 47-51. Elsevier Inc.
Plasminogen activator inhibitor 1 (PAI-1) is a glycoprotein that controls the activity of the key enzymes of the fibrinolytic system, the serine proteases tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a198529b3b1d63ebe896cf35ed85149
https://doi.org/10.1016/s1050-1738(96)00141-7
Zobrazit plný text záznamu
4
A Steady-state Template Model That Describes the Kinetics of Fibrin-stimulated [Glu1]- and [Lys78]Plasminogen Activation by Native tissue-type Plasminogen Activator and Variants That Lack Either the Finger or Kringle-2 Domain
Autor: Michael E. Nesheim, Anton J. G. Horrevoets, H. Pannekoek
Publikováno v: Journal of Biological Chemistry. 272:2183-2191
The kinetics of activation of both [Glu1]- and [Lys78]Plg(S741C-fluorescein by native (recombinant) tissue-type plasminogen activator and its deletion variants lacking either the finger or kringle-2 domain were measured by fluorescence within fully p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e5f1d59b61222b8eb3ddbb44439c8c
https://doi.org/10.1074/jbc.272.4.2183
Zobrazit plný text záznamu
5
Identification of functional interaction sites on proteins using bacteriophage-displayed random epitope libraries
Autor: H. Pannekoek, A.J. van Zonneveld, M van Meijer, B. M. van den Berg
Publikováno v: Gene, 167(1-2), 49-52. Elsevier
We describe a phage-display-based method to identify epitopes or interaction sites on proteins. DNA encoding the protein of interest is partially degraded with DNase I to generate random fragments of 50–200 bp. These fragments are then cloned into
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cede6b0e0e9b6679f89cdfc098bfed95
https://doi.org/10.1016/0378-1119(95)00614-1
Zobrazit plný text záznamu
7
The Role of the Finger Domain of Tissue-type Plasminogen Activator (t-PA) and Plasminogen Activator Inhibitor 1 (PAI-1) in Initiation and Progression of Thrombolysis
Autor: H. Pannekoek, A. Smilde, H. A. R. Stringer, A.J.G. Horrevoets, P. van Swieten
Publikováno v: Thrombosis and Haemostasis. 72:900-905
SummaryWe further investigated the role of the finger (F) and the kringle-2 (K2) domains of tissue-type plasminogen activator (t-PA) in fibrin-stimulated plasminogen activation. To that end, the action of purified (wt) t-PA or of variants lacking F (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::777612633b23e3c4b8101cf7e68457e0
https://doi.org/10.1055/s-0038-1648981
Zobrazit plný text záznamu
8
Thrombin-variable region 1 (VR1). Evidence for the dominant contribution of VR1 of serine proteases to their interaction with plasminogen activator inhibitor 1
Autor: Guido Tans, Anton J. G. Horrevoets, A. Smilde, A.J. van Zonneveld, H. Pannekoek
Publikováno v: Journal of Biological Chemistry. 268:779-782
The importance of a specific variable region in different serine proteases for the interaction with plasminogen activator inhibitor 1 (PAI-1) is studied. To that end, we have constructed a thrombin substitution variant, thrombin-VR1, in which the ent
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6adf62986cbac40e3ca4555ec447de2
https://doi.org/10.1016/s0021-9258(18)54001-1
Zobrazit plný text záznamu
9
The interaction of plasminogen activator inhibitor 1 with plasminogen activators (tissue-type and urokinase-type) and fibrin: localization of interaction sites and physiologic relevance
Autor: J Keijer, M Linders, AJ van Zonneveld, HJ Ehrlich, JP de Boer, H Pannekoek
Publikováno v: Blood. 78:401-409
Plasminogen activator inhibitor 1 (PAI-1), an essential regulatory protein of the fibrinolytic system, harbors interaction sites for plasminogen activators (tissue-type [t-PA] and urokinase-type [u-PA]) and for fibrin. In this study, anti-PAI-1 monoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fa27514c1ea7aa4b61371ef8ede9a7a
https://doi.org/10.1182/blood.v78.2.401.bloodjournal782401
Zobrazit plný text záznamu
10
Somatic origin of inherited haemophilia A
Autor: H. Pannekoek, Pieter H. Reitsma, J. J. P. van de Kamp, A. H. J. T. Bröcker-Vriends, J. C. F. M. Dreesen, Ernest Briët, B. Bakker, Peter L. Pearson
Publikováno v: Human Genetics. 85:288-292
We found a partial deletion of the clotting factor VIII gene of about 2000 bp, spanning exon 5 and part of intervening sequence 4 and 5 in an isolated patient with severe haemophilia A. The mother of the patient, who appeared to be a non-carrier on t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7d8a530da9e65ea41e17eb4095db1c
https://doi.org/10.1007/bf00206748
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje