Zobrazeno 1 - 10
of 445
pro vyhledávání: '"H. Oelschläger"'
Autor:
H. Oelschläger, R. Glöckner, Karl-Heinz Hellwich, Brit Hofmann, Sieglinde Ueberall, Dieter Müller, Andreas Seeling, Heike Machts
Publikováno v:
Arzneimittelforschung. 53:247-253
An open problem of the lipid lowering agent ciprofibrate (rac-2-[4-(2,2-dichlorocyclopropyl)-phenoxy]-2-methylpropanoic acid, CAS 52214-84-3) is its metabolism concerning the conjugation with amino acids and glucuronic acid. It could be solved by syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd0532be40c0ff0483ba7372d9f12a5
https://doi.org/10.1055/s-0031-1297104
https://doi.org/10.1055/s-0031-1297104
Publikováno v:
Skin Pharmacology and Physiology. 18:132-138
Chlormezanone is a centrally acting muscle relaxant introduced in human therapy as a racemic substance. The following investigation was performed in order to investigate whether the racemate and both enantiomers differ in their potential cytotoxicty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ecad9f660227785b6a8242bef3f190
https://doi.org/10.1159/000084910
https://doi.org/10.1159/000084910
Publikováno v:
wt Werkstattstechnik online. 93:724-728
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce70d3ef2367279a4d62e6f3f0ca61ed
https://doi.org/10.37544/1436-4980-2003-11-12-724
https://doi.org/10.37544/1436-4980-2003-11-12-724
Publikováno v:
Chromatographia. 53:559-562
A capillary electrophoresis method was developed for the separation of aminopyridines and diaminopyridines. The influence of the buffer pH and type of buffer was studied. Optimum separation conditions were 100mM sodium acetate buffer, pH 5.15, and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc764ff1e68fbf4ddb10fbe3a43f5e7
https://doi.org/10.1007/bf02491623
https://doi.org/10.1007/bf02491623
Publikováno v:
Marine Pollution Bulletin. 38:830-836
Organochlorines (DDT, toxaphene, PCBs, chlordane, HCHs, dieldrin) were quantified in the blubber of eleven fur seals of the species Arctocephalus pusillus pusillus. The sample clean-up included microwave-assisted extraction (MAE), gel-permeation chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40701ec6f433559ef400b514103cbaf
https://doi.org/10.1016/s0025-326x(99)00071-5
https://doi.org/10.1016/s0025-326x(99)00071-5
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 24:63-68
Both chlormezanone enantiomers, for the first time obtained by enantiospecific HPLC with a 100% yield, bind to oxidized cytochrome P-450 in rat liver microsomes with a binding curve according to type I, similar to hexobarbital but less pronounced. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cccbdbf99f05edcaed09538cffe236
https://doi.org/10.1007/bf03190012
https://doi.org/10.1007/bf03190012
Autor:
E. Karge, H. Oelschläger, S. Löbel, W. Kühnel, Thomas Deufel, D. Rothley, M. Klinger, Amelie Lupp, M. Danz, Martin Müller, Werner Linss, Wolfgang Klinger
Publikováno v:
Europe PubMed Central
Summary Ciprofibrates (racemate and both enantiomers, Raccip, R- and Scip) were administered orally in doses of 1 and 10 mg/kg once daily over 28 days to male inbred Fischer 344 rats, age 90–110 days at the beginning of the experiment. Body mass ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45dfe40e79e0deea56af22dc4ca2da7a
https://doi.org/10.1016/s0940-2993(98)80010-9
https://doi.org/10.1016/s0940-2993(98)80010-9
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 22:165-171
Chlormezanone binds to oxidized cytochrome P450 in rat liver microsomes with a binding curve according to type I like hexobarbital but less pronounced and with a general shift to the left. Ethylmorphine N-demethylation, ethoxycoumarin and ethoxyresor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::742b53c2fd194319cc1b7e1519e5be11
https://doi.org/10.1007/bf03189801
https://doi.org/10.1007/bf03189801
Publikováno v:
Journal of Liquid Chromatography. 15:2341-2353
A series of amino-alkylaryl-ether and thioether deriv—atives with local anesthetic activity was investigated in an IP-RP HPLC system. Good correlation was found between the retention (log k') and octanol-water partition coefficient (log P). The val
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d9cf6bacbd0152509af778d80c35b1
https://doi.org/10.1080/10826079208016182
https://doi.org/10.1080/10826079208016182
Publikováno v:
Die Pharmazie. 60(9)
Facilities for the manufacturing of pharmaceutical drug substances on the pilot-plant and the industrial scale as well as chemical reactors and vessels used for chemical work-up mainly consist of alloyed stainless steel. The influence of the alloy co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8554ded3caf1ae68e8d9b9ef26061720
https://pubmed.ncbi.nlm.nih.gov/16222864
https://pubmed.ncbi.nlm.nih.gov/16222864