Zobrazeno 1 - 10 of 33 pro vyhledávání: '"H. O. Kalkman"'
2
Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats
Autor: V. Neumann, M. D. Tricklebank, H. O. Kalkman
Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 355:361-364
Loxapine (0.3 mg/kg s.c.), olanzapine (10 mg/kg s.c.) and SCH 23390 (R-(+)-chloro-2, 3, 4, 5-tetrahydro-3-methyl-5-phenyl-1-H-3-benzazepine; 1 mg/kg, s.c.), but not clozapine (10 mg/kg, s.c.), induced catalepsy in rats. Co-administration of clozapine
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be08e0ea734daa57246b86198d8a8d3e
https://doi.org/10.1007/pl00004955
Zobrazit plný text záznamu
3
SDZ GLC 756, a novel octahydrobenzo[g]quinoline derivative exerts opposing effects on dopamine D1 and D2 receptors
Autor: A. L. Jaton, P. Gull, H. O. Kalkman, D. Hoyer, C. Rüdeberg, Stephan Urwyler, A. K. Dixon, R. Markstein
Publikováno v: Journal of Neural Transmission. 103:17-30
SDZ GLC-756, a novel octahydrobenzo[g]quinoline derivative, is equipotent in displacing [3H]SCH23390 from dopamine D1 receptors and [3H]205-501 from dopamine D2 receptor binding sites. It blocks dopamine sensitive adenylate cyclase with the same pote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662d64fbe6528d92a2cebcd1eb4f20b2
https://doi.org/10.1007/bf01292613
Zobrazit plný text záznamu
5
Discriminative stimulus properties of 8-OH-DPAT in rats are not altered by pretreatment with para-chlorophenylalanine
Autor: H. O. Kalkman
Publikováno v: Psychopharmacology. 101:39-42
The role of 5-HT1A autoreceptors in the discriminative stimulus properties of 8-OH-DPAT (0.1 mg/kg, SC) in rats, was investigated. Drug lever appropriate responding to 8-OH-DPAT (0.1 mg/kg, SC) and ipsapirone (3 mg/kg, SC) was measured before and aft
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7464b2eae1e1f88fe45eeb12f448847
https://doi.org/10.1007/bf02253715
Zobrazit plný text záznamu
6
GAD(67): the link between the GABA-deficit hypothesis and the dopaminergic- and glutamatergic theories of psychosis
Autor: E. Loetscher, H. O. Kalkman
Publikováno v: Journal of neural transmission (Vienna, Austria : 1996). 110(7)
Decreases in the 67 kDa isoenzyme of brain glutamic acid decarboxylase (GAD(67)) expression have been consistently found in patients with bipolar disorder and schizophrenia. In animals GAD(67) expression is diminished by chronic, but not acute stimul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aedb951e9645575b006f4a0e5bed6718
https://pubmed.ncbi.nlm.nih.gov/12811640
Zobrazit plný text záznamu
7
The Interaction of Atypical Neuroleptics with Monoamine Receptor Subtypes
Autor: H. O. Kalkman
Publikováno v: Leponex ISBN: 9783540411352
The prototypical classical neuroleptic agent, haloperidol is an effective antipsychotic compound but also induces severe extrapyramidal side effects and hyperprolactinaemia. The term „atypical neuroleptic“ was originally introduced to describe co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::021325697137a175db190586e47e9833
https://doi.org/10.1007/978-3-642-59454-0_6
Zobrazit plný text záznamu
8
The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat
Autor: H O, Kalkman, V, Neumann, D, Hoyer, M D, Tricklebank
Publikováno v: British journal of pharmacology. 124(7)
1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2.The close structural analogues of clozapine, loxapine (0.1 mg kg(-1) s.c.) and iso-clozapine (1 and 3 mg kg(-1
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::201827c30cd67866f66cfa9734df2b92
https://pubmed.ncbi.nlm.nih.gov/9723970
Zobrazit plný text záznamu
9
Hypersensitivity to meta-chlorophenylpiperazine (mCPP) in migraine and drug withdrawal
Autor: H O, Kalkman
Publikováno v: International journal of clinical pharmacology research. 17(2-3)
Administration of a bolus dose of mCPP, a 5-HT2C receptor agonist, to rats provokes endocrine and behavioural effects that are reminiscent of some of the symptoms of human depression. Rats exposed to chronic mild stress (which is also a key factor in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98478d9d3fe690818e84f4f2ce0518cd
https://pubmed.ncbi.nlm.nih.gov/9403358
Zobrazit plný text záznamu
10
(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity
Autor: H R Buerki, Joachim Nozulak, Philipp Floersheim, H. O. Kalkman, Daniel Hoyer, Philippe Schoeffter
Publikováno v: Journal of medicinal chemistry. 38(1)
The indolonaphthyridine 8 is described as a selective 5-HT2C/2B vs 5-HT2A receptor antagonist. The compound was synthesized in seven steps starting from indoline and isonicotinic acid chloride. The key step is a photocyclization of the indolinyl tetr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf185a20a2817799ac9e351846cfc9d
https://pubmed.ncbi.nlm.nih.gov/7837236
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje