Zobrazeno 1 - 5
of 5
pro vyhledávání: '"H. Nayanga Thirimanne"'
Publikováno v:
Upsala Journal of Medical Sciences, Vol 129, Pp 1-8 (2024)
Meningiomas, the most common primary brain tumors in adults, are often benign and curable by surgical resection. However, a subset is of higher grade, shows aggressive growth behavior as well as brain invasion, and often recurs even after several rou
Externí odkaz:
https://doaj.org/article/511d015e41a34db78a0a4899dc9bd4d5
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife, Vol 11 (2022)
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en
Externí odkaz:
https://doaj.org/article/04134ed54862435e8033d1ac577697c2
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::557304f0d5b22ba5324ef50a540c5e00
https://doi.org/10.7554/elife.74338.sa2
https://doi.org/10.7554/elife.74338.sa2
Autor:
Raphael Gottardo, Bruce E. Clurman, Feinan Wu, Patrick J. Paddison, H. Nayanga Thirimanne, Robert A. Amezquita, Jherek Swanger, Heather Feldman, Derek H. Janssens, Steven Henikoff
Fbw7 is a ubiquitin ligase substrate receptor that targets proteins for proteasomal degradation. Most known Fbw7 substrates are transcription factors (TFs) and many are also oncoproteins (e.g., c-Myc, c-Jun, Notch). Fbw7 is an important tumor suppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aee674b1a69a3cd3cbfe81f73f1b2d6
https://doi.org/10.1101/2021.10.19.464955
https://doi.org/10.1101/2021.10.19.464955
Autor:
H Nayanga Thirimanne, Feinan Wu, Derek H Janssens, Jherek Swanger, Ahmed Diab, Heather M Feldman, Robert A Amezquita, Raphael Gottardo, Patrick J Paddison, Steven Henikoff, Bruce E Clurman
Publikováno v:
eLife. 11
The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch). Fbw7 is a tumor suppressor and tumors often contain mutations in FBXW7, the gene that en