Zobrazeno 1 - 10
of 59
pro vyhledávání: '"H. N. Sabbah"'
Publikováno v:
Heart failure reviews. 5(2)
An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deteriorat
Autor:
H N, Sabbah
Publikováno v:
Cardiovascular drugs and therapy. 15(6)
Progressive left ventricular (LV) dysfunction is a characteristic feature of the failing heart. The mechanism or mechanisms that drive this progression are not known. In recent years, we advanced a working hypothesis that progressive LV dysfunction i
Autor:
H N, Sabbah, W, Haddad, Y, Mika, O, Nass, R, Aviv, V G, Sharov, V, Maltsev, B, Felzen, A I, Undrovinas, S, Goldstein, N, Darvish, S A, Ben-Haim
Publikováno v:
Heart failure reviews. 6(1)
The intravenous use of positive inotropic agents, such as sympathomimetics and phosphodiesterase inhibitors, in heart failure is limited by pro-arrhythmic and positive chronotropic effects. Chronic use of these agents, while eliciting an improvement
Publikováno v:
Cardiovascular drugs and therapy. 14(1)
The use of positive inotropic agents, such as sympathomimetics and phosphodiesterase inhibitors, in heart failure (HF) is limited by proarrhythmic and positive chronotropic effects. In the present study, we compared the hemodynamic effects of intrave
Autor:
H N, Sabbah
Publikováno v:
Clinical cardiology. 22
Enhanced and sustained cardiac adrenergic drive occurs in heart failure (HF) and contributes, in part, to the progression of left ventricular (LV) dysfunction and remodeling that are characteristic of this disease state. Enhanced sympathetic drive in
Publikováno v:
Annals of medicine. 30
A characteristic feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this haemodynamic deter
Publikováno v:
Molecular and cellular biochemistry. 187(1-2)
In intact guinea pig ventricles, acetylcholine (ACH) has been shown to attenuate the positive inotropic effects of isobutylmethylxanthine (IBMX), a phosphodiesterase inhibitor, by reducing protein phosphorylation without altering cAMP levels. In the
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(2)
Despite the marked vasodilator and antiischemic actions of existing calcium channel blockers, their use in the treatment of patients with chronic heart failure (HF) remains highly controversial. We compared the short-term hemodynamic effects of i.v.
Publikováno v:
Pharmacotherapy. 16(3)
To determine and describe relationships between plasma cocaine concentrations and electrophysiologic and electrocardiographic effects, 10 anesthetized dogs with normal intact hearts received a continuous 3-hour infusion of cocaine 0.11 mg/kg/minute (
Publikováno v:
Pharmacotherapy. 16(3)
We determined the effect of cocaine on ventricular vulnerability to fibrillation, as measured by ventricular fibrillation threshold (VFT), and cardiac electrophysiology in 20 anesthetized dogs with normal hearts. Animals were randomized in blinded fa