Zobrazeno 1 - 10
of 16
pro vyhledávání: '"H. N. Bramson"'
Autor:
Sue H. Kadwell, Domanico Pl, J. D. Stuart, G. Tian, Marcia L. Moss, T. A. Kost, L. K. Overton, Robert A. Mook, I R Patel, H. N. Bramson
Publikováno v:
Biochemistry. 33:2291-2296
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one (finasteride), which has been approved for treatment of benign prostatic hyperplasia, is shown here to be a slow time-dependent inhibitor of human steroid 5 alpha-reductase isozyme 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734895a64604489e39df0587cc4ba7af
https://doi.org/10.1021/bi00174a041
https://doi.org/10.1021/bi00174a041
Autor:
H. N. Bramson, Kenneth Batchelor, J. E. Long, Roger N. Hiner, Frank Lee, Marcia L. Moss, R. A. Jun. Mook, J. D. Stuart, J. Van Arnold, Stephen V. Frye, Stephanie L. Schweiker, Mary K. Grizzle, Curt D. Haffner, Michael K. James, Timothy K. Tippin, G. Tian, Patrick R. Maloney, S V Schuster, D. M. Bickett, Rayomand J. Unwalla, G. F. Jun. Dorsey
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c365d9b240d68257c530bd93326438d1
https://doi.org/10.1002/chin.199426234
https://doi.org/10.1002/chin.199426234
Autor:
J. Van Arnold, Kenneth Batchelor, J. D. Stuart, Stephanie L. Schweiker, D. M. Bickett, Robert Carl Andrews, Wheeler Thomas Neil, Stephen V. Frye, Frank Lee, R. A. Jun. Mook, R. N. Hiner, Patrick R. Maloney, Curt D. Haffner, John A. Ray, G. F. Jun. Dorsey, H. N. Bramson, G. Tian, Rayomand J. Unwalla, Marcia L. Moss, Cynthia Markert Cribbs, S. Croom
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43716e15564e96bfa75547adc6350a3e
https://doi.org/10.1002/chin.199451227
https://doi.org/10.1002/chin.199451227
Publikováno v:
Journal of Biological Chemistry. 266:16219-16225
In CD4+ T cells, the src-like tyrosine kinase pp56lck is associated with the CD4 receptor and cross-linking of CD4 results in the activation of this enzyme. The mechanism responsible for this activation is not known, although there is evidence that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4933cddc4f3dff9ce87407645e552abf
https://doi.org/10.1016/s0021-9258(18)98538-8
https://doi.org/10.1016/s0021-9258(18)98538-8
Autor:
James Marvin Veal, William D. Holmes, Valerie G. Montana, Lee F. Kuyper, Mark P. Edelstein, B. Lovejoy, Stephen T. Davis, Michael Joseph Luzzio, Robert T. Gampe, Philip A. Harris, Karen Lackey, H. N. Bramson, Scott Howard Dickerson, Stephen V. Frye, David W. Rusnak, Duncan Herrick Walker, A.M. Hassell, J. Corona, Robert N. Hunter, Lisa M. Shewchuk, Warren J. Rocque
Publikováno v:
Journal of medicinal chemistry. 44(25)
Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c51368d119481503765d088ccadec3
https://pubmed.ncbi.nlm.nih.gov/11728181
https://pubmed.ncbi.nlm.nih.gov/11728181
Autor:
J D, Stuart, F W, Lee, D, Simpson Noel, S H, Kadwell, L K, Overton, C R, Hoffman, T A, Kost, T K, Tippin, R L, Yeager, K W, Batchelor, H N, Bramson
Publikováno v:
Biochemical pharmacology. 62(7)
The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with 17beta-N-(2,5-bis(trifluoromethyl)phenyl)carbamoyl-4-aza-5alpha-androst-1-en-3-one (GI198745) was investigated at pH 7 and 37 degrees. This 5al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74b67dc463dbf35e4e8f4311611baf45
https://pubmed.ncbi.nlm.nih.gov/11543729
https://pubmed.ncbi.nlm.nih.gov/11543729
Publikováno v:
Pharmaceutical biotechnology. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f02c8b4b06b619f19bb6f0f8d889da38
https://pubmed.ncbi.nlm.nih.gov/9760689
https://pubmed.ncbi.nlm.nih.gov/9760689
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(3)
Selective inhibition of type 2 5alpha-reductase has been shown to be efficacious in the treatment of benign prostatic hyperplasia. Pharmacokinetic and pharmacodynamic results are reported of treatment with a potent inhibitor of both 5alpha-reductase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58b3f8270b9edb78d5c9fad0b39a0831
https://pubmed.ncbi.nlm.nih.gov/9316864
https://pubmed.ncbi.nlm.nih.gov/9316864
Autor:
S V, Frye, C D, Haffner, P R, Maloney, R A, Mook, G F, Dorsey, R N, Hiner, K W, Batchelor, H N, Bramson, J D, Stuart, S L, Schweiker
Publikováno v:
Journal of medicinal chemistry. 36(26)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de93f2428cd1673df3ff62330191adc
https://pubmed.ncbi.nlm.nih.gov/8277514
https://pubmed.ncbi.nlm.nih.gov/8277514
Publikováno v:
The Journal of biological chemistry. 266(24)
In CD4+ T cells, the src-like tyrosine kinase pp56lck is associated with the CD4 receptor and cross-linking of CD4 results in the activation of this enzyme. The mechanism responsible for this activation is not known, although there is evidence that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9af54c766ef636e0b04fac3fe8c03727
https://pubmed.ncbi.nlm.nih.gov/1908465
https://pubmed.ncbi.nlm.nih.gov/1908465