Výsledky vyhledávání - "H. N. Ananthaswamy"

Resistance to tumor necrosis factor-induced apoptosis in mouse fibroblasts is a genetically dominant phenotype

Autor: H. N. Ananthaswamy, Antonio Fernandez, David J. McConkey

Publikováno v: International journal of oncology. 8(1)

Although many tumor cells are sensitive to tumor necrosis factor (TNF)-induced cell death, most normal cells are resistant. To determine whether the sensitive phenotype or the resistant phenotype is genetically dominant, we constructed somatic cell h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fadf0a073b06c0f575fb6ea1949458c
https://pubmed.ncbi.nlm.nih.gov/21544346

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Rejection of K1735 murine melanoma in syngeneic hosts requires expression of MHC class I antigens and either class II antigens or IL-2

Autor: P W Chen, H N Ananthaswamy

Publikováno v: The Journal of Immunology. 151:244-255

Tumor specific immunity is mediated by CTL that recognize peptide Ag in the context of MHC class I molecules and by Th cells that recognize peptide Ag in the context of MHC class II molecules. To clarify the relative importance of MHC class I and II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::159219c5c45102d04fc7d7af63b9d1b5
https://doi.org/10.4049/jimmunol.151.1.244

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Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers

Autor: A, Pacifico, L H, Goldberg, K, Peris, S, Chimenti, G, Leone, H N, Ananthaswamy

Publikováno v: The British journal of dermatology. 158(2)

The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5bcecccb2b9b4be56bf248aa7a9b8bc3
https://pubmed.ncbi.nlm.nih.gov/18070208

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Detection of mutations and polymorphisms in the p53 tumor suppressor gene by single-strand conformation polymorphism analysis

Autor: L S, Kutach, S, Bolshakov, H N, Ananthaswamy

Publikováno v: Electrophoresis. 20(6)

Deciphering the genetic mechanisms in cancer development requires analysis of a large number of tumors for consistent genetic alterations. Single-strand conformational polymorphism (SSCP) analysis is a fast and efficient method for detecting mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::709a1c95830f990648ca2ffb7c907ff6
https://pubmed.ncbi.nlm.nih.gov/10380760

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Direct comparison of DNA damage, isomerization of urocanic acid and edema in the mouse produced by three commonly used artificial UV light sources

Autor: D B, Yarosh, J, Kibitel, S E, Ullrich, T H, Kim, H N, Ananthaswamy, P, Krien, A, Fourtanier, M L, Kripke

Publikováno v: Photochemistry and photobiology. 69(5)

Exposure to sunlight can result in a number of harmful effects, including sunburn, erythema, premature aging of the skin, immune suppression and skin cancer. Studies designed to understand the underlying mechanisms often depend upon the use of artifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3acca23ec6207188b03bcab5dc5f7090
https://pubmed.ncbi.nlm.nih.gov/10333763

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Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53

Autor: Q, Shi, S, Huang, W, Jiang, L S, Kutach, H N, Ananthaswamy, K, Xie

Publikováno v: Cancer research. 59(9)

The relationship between nitric oxide synthase II (NOS II) inducibility and the metastatic ability of UV-2237 murine fibrosarcoma cells was determined. Highly metastatic cells survived to produce numerous lung metastases after i.v. injection in synge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d0de43ac3a4f728cee8dade9fbbe36f
https://pubmed.ncbi.nlm.nih.gov/10232590

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Suppression of delayed and contact hypersensitivity responses in mice have different UV dose responses

Autor: T H, Kim, S E, Ullrich, H N, Ananthaswamy, S, Zimmerman, M L, Kripke

Publikováno v: Photochemistry and photobiology. 68(5)

Although acute exposure to UV radiation suppresses the induction of delayed-type (DTH) and contact (CHS) hypersensitivity in mice, it is not clear whether the photobiological mechanism(s) involved in suppressing these closely related immune reactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::331fc010ffbd329c5af1a5464d05bfd5
https://pubmed.ncbi.nlm.nih.gov/9825703

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Inhibition of UV-induced p53 mutations by sunscreens: implications for skin cancer prevention

Autor: H N, Ananthaswamy, S M, Loughlin, S E, Ullrich, M L, Kripke

Publikováno v: The journal of investigative dermatology. Symposium proceedings. 3(1)

Ultraviolet (UV) radiation is a potent human carcinogen and it induces skin cancer in experimental animals. Recent studies have shown that unique mutations in the p53 tumor suppressor gene contribute to the development of human and mouse UV-induced s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f22c6592ac3790c4a845fadaa4f69208
https://pubmed.ncbi.nlm.nih.gov/9732059

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