Zobrazeno 1 - 10
of 74
pro vyhledávání: '"H. Munday"'
Publikováno v:
The Journal of Organic Chemistry. 88:5275-5284
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e9089ab001a610c31bf6b180a57365a
https://doi.org/10.1021/acs.joc.2c02588
https://doi.org/10.1021/acs.joc.2c02588
Autor:
Marian C. Bryan, Charlotte Dalton, Alba Díaz-Rodríguez, Jaika Doerfler, Oliver D. Engl, Alejandro Gimenez Molina, Vanessa Harawa, Christopher B. Kelly, Wei Li, Rachel H. Munday, Jan Pawlas, Paul F. Richardson, William J. Smith, Alan Steven, Balaram S. Takale, Jack A. Terrett, Daniel S. Treitler, Mingshuo Zeng
Publikováno v:
Organic Process Research & Development. 27:563-570
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75cfa86fb3968343526278f23eeebbad
https://doi.org/10.1021/acs.oprd.3c00065
https://doi.org/10.1021/acs.oprd.3c00065
Publikováno v:
Accounts of Chemical Research. 55:2938-2948
ConspectusAtropisomerism is a stereochemical phenomenon exhibited by molecules containing a rotationally restricted σ bond. Contrary to classical point chirality, the two atropisomeric stereoisomers exist as a dynamic mixture and can be interconvert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251820470592b93c040a0dbfa0d81e52
https://doi.org/10.1021/acs.accounts.2c00513
https://doi.org/10.1021/acs.accounts.2c00513
Autor:
James Morrison, Rachel H. Munday, Thomas O. Ronson, Matthew R. Tatton, Hucheng Zhao, Calum Cook, Daniël de Bruin, Kevin William Leslie, Kuangchu Dai, David Buttar, Catalina Ferrer, James Douglas
Publikováno v:
The Journal of Organic Chemistry. 87:2075-2086
Route design and proof of concept synthesis was conducted on a synthetically challenging atropisomeric KRASG12C inhibitor to support clinical API manufacture. Improvements to the synthesis of a chiral piperazine fragment gave reduced step count and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d65021692c0dd447f9a4a289efaf63
https://doi.org/10.1021/acs.joc.1c01736
https://doi.org/10.1021/acs.joc.1c01736
Autor:
Charlotte Dalton, Louis J. Diorazio, Jaika Doerfler, Oliver D. Engl, Zhengxu S. Han, Gareth P. Howell, Jonathan Latham, Wei Li, Mark McLaws, Rachel H. Munday, Antonio Navarro, Michael Parmentier, Jan Pawlas, Paul Richardson, Gheorghe-Doru Roiban, Alan Steven, Jack A. Terrett, Daniel S. Treitler, Mingshuo Zeng
Publikováno v:
Organic Process Research & Development. 25:703-712
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c4e78405e7f843c43041b651477123
https://doi.org/10.1021/acs.oprd.1c00067
https://doi.org/10.1021/acs.oprd.1c00067
Autor:
Anne O’Kearney-McMullan, Jorge García-Lacuna, C. Oliver Kappe, Tobias Fleiß, Rachel H. Munday, Christopher A. Hone, Kevin William Leslie
Publikováno v:
Organic Process Research & Development. 25:947-959
The development of a continuous-flow sequence for the synthesis of an important drug candidate precursor is reported. Abediterol is a β2-adrenoceptor agonist that has undergone phase IIa clinical t...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e29a63d2cf5a82b0c0ff92c52f9ee4
https://doi.org/10.1021/acs.oprd.1c00002
https://doi.org/10.1021/acs.oprd.1c00002
Autor:
Zhang Enxuan, Chris D. Parsons, David C. McKinney, Kevin William Leslie, Zhi-qing Liu, Miguel Gonzalez, Mark A. Graham, Jackson Lucinda Victoria, Rachel H. Munday, Jun-wang Zhang, Janette H. Cherryman, James Douglas, David Whittaker, Gary M. Noonan
Publikováno v:
Organic Process Research & Development. 25:57-67
New route development activities toward ceralasertib (AZD6738) have resulted in the discovery of an efficient, acid additive-free, photoredox Minisci reaction. Mechanistic understanding resulting f...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08740d393a7148e1911afcefc4eab4f1
https://doi.org/10.1021/acs.oprd.0c00483
https://doi.org/10.1021/acs.oprd.0c00483
Autor:
Per-Ola Norrby, Liam Byrne, Christian Sköld, Peter D. Smith, Rachel H. Munday, Andrew R. Turner
Publikováno v:
Advanced Synthesis & Catalysis. 363:259-267
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a6e482cd06d1d8e6f24b31fd18d63e
https://doi.org/10.1002/adsc.202001211
https://doi.org/10.1002/adsc.202001211
Autor:
Jorge García-Lacuna, Kevin William Leslie, Anne O’Kearney-McMullan, C. Oliver Kappe, Christopher A. Hone, Rachel H. Munday, Michael Prieschl
Publikováno v:
Green Chemistry. 22:5762-5770
The development of a ruthenium-catalyzed continuous flow ester hydrogenation using hydrogen (H2) gas is reported. The reaction was utilized for the reduction of an important precursor in the synthesis of abediterol, a β2-adrenoceptor agonist that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e2be84a06b7ddda6a08f17d76b4949
https://doi.org/10.1039/d0gc02225j
https://doi.org/10.1039/d0gc02225j
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