Zobrazeno 1 - 10
of 659
pro vyhledávání: '"H. McLaughlin"'
Autor:
Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract APC/C is a multi-subunit complex that functions as a master regulator of cell division. It controls progression through the cell cycle by timely marking mitotic cyclins and other cell cycle regulatory proteins for degradation. The APC/C itse
Externí odkaz:
https://doaj.org/article/589f354937f84c75bfa553a6d658d72c
Autor:
Elyse S. Fischer, Conny W. H. Yu, Johannes F. Hevler, Stephen H. McLaughlin, Sarah L. Maslen, Albert J. R. Heck, Stefan M. V. Freund, David Barford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Formation of the mitotic checkpoint complex (MCC) is catalysed by a phosphorylation-dependent scaffold. This work provides structural details of how a tripartite Mad1:Bub1:Cdc20 complex presents Cdc20 to Mad2, triggering open-to-closed conversion of
Externí odkaz:
https://doaj.org/article/25af90ef4aa84deab038bcc19c9bacc5
Autor:
Kate R. Griffiths, Jacob L. H. McLaughlin, Felicity Hall, Lina Partis, Samuel C. Hansen, Rachel Tulloch, Daniel G. Burke
Publikováno v:
Foods, Vol 12, Iss 20, p 3839 (2023)
Laboratory testing methods to confirm the identity of meat products and eliminate food fraud regularly rely on PCR amplification of extracted DNA, with most published assays detecting mitochondrial sequences, providing sensitive presence/absence resu
Externí odkaz:
https://doaj.org/article/3aefaec642934dc1a2c84efb865e4f5e
Autor:
Leifu Chang, Jing Yang, Chang Hwa Jo, Andreas Boland, Ziguo Zhang, Stephen H. McLaughlin, Afnan Abu-Thuraia, Ryan C. Killoran, Matthew J. Smith, Jean-Francois Côté, David Barford
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
DOCK2 is a guanine nucleotide exchange factor (GEF) that activates RHO GTPases and interacts with ELMO1, which stimulates its GEF activity. Here, the authors provide mechanistic insights into how ELMO1 regulates DOCK2 activity by determining the stru
Externí odkaz:
https://doaj.org/article/d8a372772f44414b8c28c69fb426524f
Autor:
Leo Kiss, Jingwei Zeng, Claire F. Dickson, Donna L. Mallery, Ji-Chun Yang, Stephen H. McLaughlin, Andreas Boland, David Neuhaus, Leo C. James
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The E3 ligase TRIM21 targets a broad range of pathogenic proteins using a unique mechanism. Here, the authors combine structural, biochemical and cell biological approaches to elucidate how TRIM21 selectively recruits its canonical E2 partner enzyme
Externí odkaz:
https://doaj.org/article/470293ee22be4d32ba89b9430667e524
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f8e36156cc591a3aec34b2fffc9688
https://doi.org/10.1038/s41586-023-05972-2
https://doi.org/10.1038/s41586-023-05972-2
Publikováno v:
American Journal of Physical Medicine & Rehabilitation. 102:S75-S78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94cd751ae1a0a46c79c142c0ba296eee
https://doi.org/10.1097/phm.0000000000002143
https://doi.org/10.1097/phm.0000000000002143
Autor:
Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates
Externí odkaz:
https://doaj.org/article/64d5bf6e3d9f4b17ae080b2ad6edfff9
Autor:
Kevin H. McLaughlin, Michael Friedman, Erik H. Hoyer, Sapna Kudchadkar, Eleni Flanagan, Lisa Klein, Kelly Daley, Annette Lavezza, Nicole Schechter, Daniel Young
Publikováno v:
Journal of Nursing Care Quality. 38:164-170
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf341f8341811e2b474c24c40635740f
https://doi.org/10.1097/ncq.0000000000000678
https://doi.org/10.1097/ncq.0000000000000678
Autor:
Tim Nierhaus, Stephen H. McLaughlin, Frank Bürmann, Danguole Kureisaite-Ciziene, Sarah L. Maslen, J. Mark Skehel, Conny W. H. Yu, Stefan M. V. Freund, Louise F. H. Funke, Jason W. Chin, Jan Löwe
Publikováno v:
Nature Microbiology. 7:1686-1701
During bacterial cell division, filaments of tubulin-like FtsZ form the Z-ring, which is the cytoplasmic scaffold for divisome assembly. In Escherichia coli, the actin homologue FtsA anchors the Z-ring to the membrane and recruits divisome components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86d9870695cc5a6de38f025a15dd11
https://doi.org/10.1038/s41564-022-01206-9
https://doi.org/10.1038/s41564-022-01206-9