Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery

Autor: H. Mayumi Homi, Yi Hung Wu, Rebecca Scholl, Edmund H. Jooste, Brian S. Donahue, Kelly A. Machovec, Robert Douglas Benjamin Jaquiss, Nathaniel H. Greene, Nirmish Shah, Warwick A. Ames, Andrew J. Lodge, Claudia Benkwitz

Publikováno v: Journal of cardiothoracic and vascular anesthesia, vol 33, iss 2
Jooste, EH; Scholl, R; Wu, Y-H; Jaquiss, RDB; Lodge, AJ; Ames, WA; et al.(2018). Double-Blind, Randomized, Placebo-Controlled Trial Comparing the Effects of Antithrombin Versus Placebo on the Coagulation System in Infants with Low Antithrombin Undergoing Congenital Cardiac Surgery.. Journal of cardiothoracic and vascular anesthesia. doi: 10.1053/j.jvca.2018.05.052. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8rh2k10f

Objectives To determine whether precardiopulmonary bypass (CPB) normalization of antithrombin levels in infants to 100% improves heparin sensitivity and anticoagulation during CPB and has beneficial effects into the postoperative period. Design Rando

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af0879675eba3f8ed6ad05f4e3eeb1d
https://pubmed.ncbi.nlm.nih.gov/30087026

Cerebral ischemiastroke and small ubiquitin-like modifier (SUMO) conjugation a new target for therapeutic intervention?

Autor: Wulf Paschen, H. Mayumi Homi, Huaxin Sheng, David S. Warner, Wei Yang

Publikováno v: Journal of Neurochemistry. 106:989-999

Transient cerebral ischemia/stroke activates various post-translational protein modifications such as phosphorylation and ubiquitin conjugation that are believed to play a major role in the pathological process triggered by an interruption of blood s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::583448f11ac9a7362efc909dbdbe581b
https://doi.org/10.1111/j.1471-4159.2008.05404.x

Cognitive Dysfunction After Cardiac Surgery: Revisiting Etiology

Autor: H. Mayumi Homi, Ferenc Puskas, Hilary P. Grocott

Publikováno v: Seminars in Cardiothoracic and Vascular Anesthesia. 9:123-129

Cognitive dysfunction remains a frequent complication of cardiac surgery. Despite many years of research, few preventive strategies and no definitive therapeutic options exist for the management of this troublesome clinical problem. This shortcoming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007556ef5e7972d6f5029d4d64517678
https://doi.org/10.1177/108925320500900204

'Other' Neurologic Complications After Cardiac Surgery

Autor: Ajeet D. Sharma, H. Mayumi Homi, Hilary P. Grocott, Jeffrey A. Clark

Publikováno v: Seminars in Cardiothoracic and Vascular Anesthesia. 8:213-226

Compared to the neurologic morbidity of stroke and cognitive dysfunction, “other” neurologic complications involving injuries to the brachial plexus, phrenic nerve, cranial nerves, other peripheral nerves, as well as the visual pathways, have bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc83866ff817e56a2012ded36ad27db0
https://doi.org/10.1177/108925320400800304

Aprotinin improves functional outcome but not cerebral infarct size in an experimental model of stroke during cardiopulmonary bypass

Autor: G. Burkhard Mackensen, H. Mayumi Homi, Hilary P. Grocott, Huaxin Sheng, Gowthami M. Arepally

Publikováno v: Anesthesia and analgesia. 111(1)

BACKGROUND Aprotinin, a nonspecific serine protease inhibitor, has been used to decrease bleeding and reduce the systemic inflammatory response after cardiopulmonary bypass (CPB). Studies have variably linked aprotinin administration with both improv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e4a4bc252c5f569cd6e14f4dd37f7a
https://pubmed.ncbi.nlm.nih.gov/20519424