Výsledky vyhledávání - "H. M. Verheul"

Akademický článek

A Panel of High Resolution Melting (HRM) Technology-Based Assays with Direct Sequencing Possibility for Effective Mutation Screening of EGFR and K-ras Genes

Autor: D. A. M. Heideman, F. B. Thunnissen, M. Doeleman, D. Kramer, H. M. Verheul, E. F. Smit, P. E. Postmus, C. J. L. M. Meijer, G.A. Meijer, P. J. F. Snijders

Publikováno v: Cellular Oncology, Vol 31, Iss 5, Pp 329-333 (2009)

Background: Increasing data from clinical trials support EGFR and K-ras mutation status as predictive markers of tumour response to EGFR-targeted therapies. Consequently, rapid and reliable mutation screening assays are demanded to guide rational use

Externí odkaz: https://doaj.org/article/0ea96d7979ce4bb1a0a7eaa416f018b2

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Molecular mechanisms and modulation of key pathways underlying the synergistic interaction of sorafenib with erlotinib in non-small-cell-lung cancer (NSCLC) cells

Autor: E, Giovannetti, M, Labots, H, Dekker, E, Galvani, J S W, Lind, R, Sciarrillo, R, Honeywell, E F, Smit, H M, Verheul, G J, Peters

Publikováno v: Current pharmaceutical design. 19(5)

Combination of drugs with different targets is a logical approach to overcome multilevel cross-stimulation among key pathways in NSCLC progression such as EGFR, K-Ras and VEGFR. The sorafenib-erlotinib combination showed clinical activity and accepta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2532d21bc33e99dc5680d25b69e3273c
https://pubmed.ncbi.nlm.nih.gov/22973961

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