Phenotypic screening of the ‘Kurz-box’ of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus

Autor: Linh Thuy Nguyen, Thomas Kurz, Sarah Preston, Hjoerdis Brueckmann, Beate Lungerich, H. M. P. Dilrukshi Herath, Anson V. Koehler, Tao Wang, Lenka Skálová, Abdul Jabbar, Robin B. Gasser

Publikováno v: Parasites & Vectors, Vol 12, Iss 1, Pp 1-9 (2019)

Abstract Background Due to anthelmintic resistance problems, there is a need to discover and develop new drugs for the treatment and control of economically important and pathogenic nematodes of livestock animals. With this focus in mind, we screened

Externí odkaz: https://doaj.org/article/667512ea98824374a6e5446300f762b8

Assessing the efficacy of albendazole against hookworm in Vietnam using quantitative PCR and sodium nitrate flotation.

Autor: Clare E F Dyer, Naomi E Clarke, Dinh Ng Nguyen, H M P Dilrukshi Herath, Sze Fui Hii, Russell Pickford, Rebecca J Traub, Susana Vaz Nery

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010767 (2022)

Preventive chemotherapy (PC), consisting of the regular distribution of anthelmintics to populations or groups of populations at risk, is the primary tool used to control soil-transmitted helminth (STH) infections. This strategy, whilst cost-effectiv

Externí odkaz: https://doaj.org/article/507b297974334bab8f84a7015caffa2e

Assessing the efficacy of albendazole against hookworm in Vietnam using quantitative PCR and sodium nitrate flotation

Autor: Clare E. F. Dyer, Naomi E. Clarke, Dinh Ng Nguyen, H. M. P. Dilrukshi Herath, Sze Fui Hii, Russell Pickford, Rebecca J. Traub, Susana Vaz Nery

Publikováno v: PLoS neglected tropical diseases. 16(10)

Preventive chemotherapy (PC), consisting of the regular distribution of anthelmintics to populations or groups of populations at risk, is the primary tool used to control soil-transmitted helminth (STH) infections. This strategy, whilst cost-effectiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44a4f6eda04d0e0925c870a950d1638
https://pubmed.ncbi.nlm.nih.gov/36315591

Selected α-pyrones from the plants Cryptocarya novoguineensis (Lauraceae) and Piper methysticum (Piperaceae) with activity against Haemonchus contortus in vitro

Autor: Sasha Hayes, Bill C.H. Chang, Andreas Hofmann, Tao Wang, H. M. P. Dilrukshi Herath, Rohan A. Davis, Jose F. Garcia-Bustos, Abdul Jabbar, R. S. Addison, Sarah Preston, Anson V. Koehler, Robin B. Gasser, Topul Rali

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss, Pp 72-79 (2019)
International Journal for Parasitology: Drugs and Drug Resistance

Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4e27caf76536c9b8afaf19e050c58e
http://www.sciencedirect.com/science/article/pii/S2211320718301581

Advances in the discovery and development of anthelmintics by harnessing natural product scaffolds

Autor: Nghi Nguyen, Brad E. Sleebs, Aya C Taki, Sarah Preston, H. M. P. Dilrukshi Herath, Andreas Hofmann, Abdul Jabbar, Rohan A. Davis, Robin B. Gasser

Publikováno v: Advances in Parasitology ISBN: 9780128246030

Widespread resistance to currently-used anthelmintics represents a major obstacle to controlling parasitic nematodes of livestock animals. Given the reliance on anthelmintics in many control regimens, there is a need for the continued discovery and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e291db961e5334726a2981d5d8ca2212
https://doi.org/10.1016/bs.apar.2020.10.002