Výsledky vyhledávání - "H. M. Korchak"

Cromolyn inhibits assembly of the NADPH oxidase and superoxide anion generation by human neutrophils

Autor: L E Kilpatrick, E Jakabovics, L J McCawley, L H Kane, H M Korchak

Publikováno v: The Journal of Immunology. 154:3429-3436

Early and late phase reactions have been observed in asthma; the late phase reaction is characterized by accumulation of inflammatory cells such as neutrophils. Activated neutrophils degranulate and assemble an active NADPH oxidase, which generates s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::844ffbf8d37b295d6b43298964ff9764
https://doi.org/10.4049/jimmunol.154.7.3429

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Bovine parainfluenza-3 virus selectively depletes a calcium-independent, phospholipid-dependent protein kinase C and inhibits superoxide anion generation in bovine alveolar macrophages

Autor: R M Dyer, S Majumdar, S D Douglas, H M Korchak

Publikováno v: The Journal of Immunology. 153:1171-1179

Bovine parainfluenza-3 (PI-3) virus inhibits oxygen-dependent bacterial killing by phagocytes, a key pulmonary defense, thus predisposing the host to intrapulmonary bacterial superinfection. PI-3 virus inhibited opsonized zymosan or PMA-activated sup

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5aa4ec782b187658c49d9e53fdde55df
https://doi.org/10.4049/jimmunol.153.3.1171

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Enhancement of macrophage candidacidal activity by interferon-gamma. Increased phagocytosis, killing, and calcium signal mediated by a decreased number of mannose receptors

Autor: Richard P. MacDermott, László Maródi, D C Anderson, Stefan Schreiber, R B Johnston, H M Korchak

Publikováno v: Journal of Clinical Investigation. 91:2596-2601

In contrast to its macrophage-activating capacity, IFN-gamma downregulates expression of the macrophage mannose receptor (MMR), which mediates uptake of Candida and other microorganisms. We found that IFN-gamma induced a concentration-dependent incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34026e365fad96b8a3737580321f09c9
https://doi.org/10.1172/jci116498

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Juvenile neuronal ceroid‐lipofuscinosis: Characterization of the dyslipoproteinaemia and demonstration of membrane phospholipid and phospholipid‐dependent signal transduction abnormalities in cultured skin fibroblasts

Autor: S. F. Poirier, A. R. Gayton, L. Chern, G. P. Hosking, N. A. Le, S. Majumdar, Michael J. Bennett, H. M. Korchak

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3821f2a9e56940d0b116256d8a95433d
https://doi.org/10.1007/bf00710272

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Alpha-1-antichymotrypsin inhibits the NADPH oxidase-enzyme complex in phorbol ester-stimulated neutrophil membranes

Autor: L Kilpatrick, L McCawley, V Nachiappan, W Greer, S Majumdar, H M Korchak, S D Douglas

Publikováno v: The Journal of Immunology. 149:3059-3065

The generation of superoxide anion and release of granule contents are essential to the bactericidal function of neutrophils, but may also contribute to host tissue damage during inflammation. In previous studies (J. Immunol. 146:2388), we have demon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4681a0b863352191d60606d6aa699f50
https://doi.org/10.4049/jimmunol.149.9.3059

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Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells

Autor: Jude T. Deeney, M Prentki, H M Korchak, Barbara E. Corkey, Keith Tornheim

Publikováno v: Journal of Biological Chemistry. 267:19840-19845

Cytosolic free Ca2+ rises in pancreatic beta-cells in response to glucose stimulation and is part of the coupling to insulin secretion. This study evaluates a possible role for cytosolic long chain acyl-CoA esters in modulating Ca2+ handling by clona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::393eca47e4b2234be96f2d20fa440305
https://doi.org/10.1016/s0021-9258(19)88631-3

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Early changes in cytosolic calcium and membrane potential induced by Actinobacillus actinomycetemcomitans leukotoxin in susceptible and resistant target cells

Autor: N S Taichman, M Iwase, E T Lally, S J Shattil, M E Cunningham, H M Korchak

Publikováno v: The Journal of Immunology. 147:3587-3594

Actinobacillus actinomycetemcomitans produces a cytolytic peptide leukotoxin which kills susceptible target cells, including human neutrophils, monocytes, lymphocytes, and HL-60 promyelocytic leukemia cells. Cell death occurs as a consequence of coll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bae59a2af662960f39cb6c2c8dca7dd
https://doi.org/10.4049/jimmunol.147.10.3587

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Mechanisms of host defense against Candida species. I. Phagocytosis by monocytes and monocyte-derived macrophages

Autor: L Maródi, H M Korchak, R B Johnston

Publikováno v: The Journal of Immunology. 146:2783-2789

We studied the biochemical basis of phagocytosis of Candida albicans, a serious pathogen, and Candida parapsilosis, which is rarely pathogenic, by human monocytes (Mo) and monocyte-derived macrophages (MDM). Optimal phagocytosis of both species by Mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79f9495f39815bfc4848c66ea8d292d3
https://doi.org/10.4049/jimmunol.146.8.2783

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Effects of cations and osmotic protectants on cytolytic activity of Actinobacillus actinomycetemcomitans leukotoxin

Autor: P Berthold, Masayasu Iwase, H M Korchak, E T Lally, N S Taichman

Publikováno v: Infection and Immunity. 58:1782-1788

Actinobacillus actinomycetemcomitans leukotoxin permeabilized the plasma membrane of HL-60 promyelocytic leukemia cells, resulting in colloid osmotic lysis. These events were associated with efflux of 51chromium (from prelabeled cells), influx of pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2033b6200404e7a37cc50c90639edffc
https://doi.org/10.1128/iai.58.6.1782-1788.1990

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Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells

Autor: G C, Yaney, H M, Korchak, B E, Corkey

Publikováno v: Endocrinology. 141(6)

Pancreatic beta-cells contain protein kinase C (PKC) isoforms that may play a role in insulin secretion. Activity of PKC classes (cPKC, nPKC, aPKC) and their regulation by acyl-CoA derivatives was examined in extracts of clonal pancreatic beta-cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09435ad197b6a7dda0a96a5b3a630e6b
https://pubmed.ncbi.nlm.nih.gov/10830281

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