Potential business model for a European vaccine R&D infrastructure and its estimated socio-economic impact [version 1; peer review: 1 approved, 2 approved with reservations]

Autor: Nicolas Collin, Donata Medaglini, Arjen Sloots, Maria Lawrenz, Jan A.M. Langermans, Roger Le Grand, Norbert Stockhofe-Zurwieden, Francesca Morelli, Fabrice Laurent, Frédéric Lantier, Alexandre Dobly, Dennis Christensen, Joaquim Segalés, H. M. Dockrell, Mei Mei Ho, Ole Olesen, Tom H.M. Ottenhoff, Frank A.W. Verreck, Stefan Jungbluth, Sven Arnouts, Manuel J. T. Carrondo, David Morrow, Fran Van Heuverswyn, Carlos A. Guzman, Anton Ussi, Monika Slezak, Hilde Depraetere, William Martin

Publikováno v: F1000Research, Vol 12 (2023)

Background Research infrastructures are facilities or resources that have proven fundamental for supporting scientific research and innovation. However, they are also known to be very expensive in their establishment, operation and maintenance. As by

Externí odkaz: https://doaj.org/article/9b023d85cc924663a81aea22af5b7578

Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

Autor: Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a string

Externí odkaz: https://doaj.org/article/1eba36dc045c44aa95b786e37918a63e

Point of care HbA

Autor: P, Huangfu, Y V, Laurence, B, Alisjahbana, C, Ugarte-Gil, A-L, Riza, G, Walzl, R, Ruslami, D A J, Moore, M, Ioana, S, McAllister, K, Ronacher, R C, Koesoemadinata, D, Grint, S, Kerry, J, Coronel, S T, Malherbe, U, Griffiths, H M, Dockrell, P C, Hill, R, van Crevel, F, Pearson, J A, Critchley

Publikováno v: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 23(3)

Diabetes mellitus (DM) is common among tuberculosis (TB) patients and often undiagnosed or poorly controlled. We compared point of care (POC) with laboratory glycated haemoglobin (HbAWe measured POC and accredited laboratory HbAOverall mean POC HbAPO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c995e0f72dcad0fda55e41d624ce306
https://pubmed.ncbi.nlm.nih.gov/30871659

Immunization against leprosy

Autor: H. M. Dockrell, K. P. W. J. McAdam

Publikováno v: Recent Developments in Prophylactic Immunization ISBN: 9789401069694

In 1978 the WHO Committee on the Immunology of Leprosy, IMMLEP, defined the development of a prophylactic vaccine against leprosy as an objective of high priority. Ten years later, trials are under way of the approaches they identified, namely, vacci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::646640a4e66b17648cd18807097af79d
https://doi.org/10.1007/978-94-009-1067-6_4

Association of slow recovery of Mycobacterium africanum-infected patients posttreatment with high content of Persister-Like bacilli in pretreatment sputum

Autor: Leopold D Tientcheu, Andrew Bell, Oumie Secka, Abigail Ayorinde, Jacob Otu, Nathalie J Garton, Jayne S Sutherland, Martin O Ota, Martin Antonio, H M Dockrell, Beate Kampmann, Michael R Barer

Publikováno v: International Journal of Mycobacteriology, Vol 5, Iss 5, Pp 99-100 (2016)

Objectives/Background: Mycobacterium africanum that causes 40% of tuberculosis (TB) in West Africa grows more slowly in culture and has similar transmission capacity compared with Mycobacterium tuberculosis, but M. africanum-exposed contacts progress

Externí odkaz: https://doaj.org/article/58d1df23f39b44d6ab28f5c9a4c581f0