Výsledky vyhledávání - "H. Lorberboum"

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Mechanisms of dichotomous action of IL-2-Pseudomonas exotoxin 40 (IL-2-PE40) on cell-mediated and humoral immune response

Autor: H D Volk, S Müller, S Yarkoni, T Diamantstein, H Lorberboum-Galski

Publikováno v: The Journal of Immunology. 153:2497-2505

IL-2-PE40 is a chimeric protein composed of human IL-2 genetically fused to the amino terminus of a modified form of Pseudomonas exotoxin lacking its cell recognition domain. The immunosuppressive efficacy of IL-2-PE40 was demonstrated in several exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bdb36134d1f5b001ed2fe2468a4e186
https://doi.org/10.4049/jimmunol.153.6.2497

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IL-2-PE40 prevents the development of tumors in mice injected with IL-2 receptor expressing EL4 transfectant tumor cells

Autor: R W Kozak, H Lorberboum-Galski, L Jones, R K Puri, M C Willingham, T Malek, D J Fitzgerald, T A Waldmann, I Pastan

Publikováno v: The Journal of Immunology. 145:2766-2771

A number of different immunotherapeutic reagents are currently being developed to target IL-2R for the treatment of leukemia, graft rejection, and certain autoimmune diseases. Previously, we have shown that IL-2-PE40, a chimeric protein composed of h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f7ae3c7c1fb822d9c157366aba23ad6
https://doi.org/10.4049/jimmunol.145.8.2766

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IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes

Autor: Thomas A. Waldmann, Maurice K. Gately, Richard E. Clark, Desmond J. Fitzgerald, Vijay K. Chaudhary, H. Lorberboum-Galski, P. S. Brown, R. J. Garsia, Ira Pastan

Publikováno v: Journal of Biological Chemistry. 265:16311-16317

To produce a molecule that will kill activated T cells as well as lymphomas and leukemias expressing interleukin 2 (IL2) receptors, we have created a recombinant chimeric protein in which IL2 is attached in peptide linkage to a truncated mutant form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::560d0a0e2703303a1c9e6f393a29edd6
https://doi.org/10.1016/s0021-9258(17)46224-7

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GnRH-Bik/Bax/Bak chimeric proteins target and kill adenocarcinoma cells; the general use of pro-apoptotic proteins of the Bcl-2 family as novel killing components of targeting chimeric proteins

Autor: Y, Azar, H, Lorberboum-Galski

Publikováno v: Apoptosis : an international journal on programmed cell death. 5(6)

In recent years chimeric proteins carrying bacterial toxins as their killing moiety, have been developed to selectively recognize and kill cell populations expressing speciific receptors. The involvement of Gonadotropin releasing hormone (GnRH) has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ffdeeb04edb67a5fad558b812779387
https://pubmed.ncbi.nlm.nih.gov/11303912

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Administration of IL-2-PE40 via osmotic pumps prevents adjuvant induced arthritis in rats. Improved therapeutic index of IL-2-PE40 administered by continuous infusion

Autor: Robert Lafyatis, Ira Pastan, John Case, David J. FitzGerald, Ronald L. Wilder, H. Lorberboum-Galski

Publikováno v: International journal of immunopharmacology. 13(2-3)

IL-2-PE40 is a chimeric cytotoxin composed of interleukin 2 (IL-2) fused to a truncated form of Pseudomonas exotoxin (PE) that lacks its binding domain. IL-2-PE40 has been shown to exhibit therapeutic potency in several models in vivo when administer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d70ec70c8dfa6e0ef6f98ffddd07b4a
https://pubmed.ncbi.nlm.nih.gov/2071302

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IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes

Autor: H, Lorberboum-Galski, R J, Garsia, M, Gately, P S, Brown, R E, Clark, T A, Waldmann, V K, Chaudhary, D J, FitzGerald, I, Pastan

Publikováno v: The Journal of biological chemistry. 265(27)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94799cdca86717bed2c421be3fc320ba
https://pubmed.ncbi.nlm.nih.gov/1975810

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