Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin

Autor: O H Morand, J D Aebi, H Dehmlow, Y H Ji, N Gains, H Lengsfeld, J Himber

Publikováno v: Journal of Lipid Research, Vol 38, Iss 2, Pp 373-390 (1997)

2,3-Oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxyst

Externí odkaz: https://doaj.org/article/97a0b72eee25483aaacfb30566d5339b

Natural abundance 13C-NMR spectroscopy for the quantitative determination of fecal fat

Autor: Basil Künnecke, I Kunz, P Kunz, H Lengsfeld, M. von Kienlin

Publikováno v: Clinical Biochemistry. 36:505-510

Objective To evaluate 13 C-NMR spectroscopy as a method for fat quantitation in human feces without time consuming or unpleasant preparation steps. Design and Methods: Stool samples of seven healthy subjects were collected for 18 days before and duri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b6b5101bb1e829d7c1072df57f16e6e
https://doi.org/10.1016/s0009-9120(03)00075-4

Monitoring the intragastric distribution of a colloidal drug carrier model by magnetic resonance imaging460

Autor: H, Faas, W, Schwizer, C, Feinle, H, Lengsfeld, C, de Smidt, P, Boesiger, M, Fried, T, Rades

Publikováno v: Pharmaceutical research. 18(4)

Monitoring the distribution of drugs or drug delivery systems in the human gastrointestinal tract is an important prerequisite for the design of orally administered drugs. We investigated the intragastric distribution of a colloidal drug delivery sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4da00eecb5a77b7d43f991e58404ec9
https://pubmed.ncbi.nlm.nih.gov/11451032

Covalent inactivation of lipases

Autor: S, Ransac, Y, Gargouri, F, Marguet, G, Buono, C, Beglinger, P, Hildebrand, H, Lengsfeld, P, Hadváry, R, Verger

Publikováno v: Methods in enzymology. 286

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::893759af42fb58ef7ee27ce2e642cb06
https://pubmed.ncbi.nlm.nih.gov/9309652

Tenth Annual Meeting of the European Association for the Study of Diabetes

Autor: K. G. M. M. Alberti, J. Iversen, N. J. Christensen, A. Andersson, Claire Jarrousse, Arne Andersson, Claes Hellerström, D. Andreani, G. Tamburrano, S. Tamburrano, S. Gambardella, Joy Ardill, D. A. D. Montgomery, D. R. Hadden, R. Assan, J. R. Attali, A. Selmi, N. Bourdillat, E. Soufflet, J. R. Girard, J. S. Bajaj, G. S. Chinna, S. K. Garg, Baldev Singh, E. O. Balasse, M. A. Neef, W. Beischer, F. Melani, L. Keller, M. Hinz, A. Kroder, V. Maier, E. F. Pfeiffer, M. Bendayan, E. Sandborn, E. Rasio, D. Bensoussan, S. Levy-Toledano, P. Passa, J. Caen, M. Berger, M. N. Goodman, S. A. Hagg, N. B. Ruderman, J. Beyer, U. Cordes, H. Travniczek, W. Heider, K. Schöffling, J. Happ, H. Grimm, W. Pünchera, P. H. Althoff, A. Fröhlich, A. R. Bianco, R. H. Schwartz, B. S. Handwerger, P. J. Blackshear, P. A. H. Holloway, D. H. Williamson, L. Boquist, Bo Hellman, Åke Lernmark, Inge-Bert Täljedabl, P. Bottermann, U. Schweigart, Th. Zilker, W. Hansen, E. Brachet, C. Rogister, Y. Broer, P. Freychet, G. Rosselin, H. Brunengraber, F. Vertongen, M. Boutry, F. Camu, P. Christacopoulos, B. Karamanos, P. Papadimitriou, Ch. Kardatos, Niels Juel Christensen, Bent Neubauer, Jean Christophe, Jacques Winand, Jean Dehaye, G. S. Cuendet, E. G. Loten, B. Jeanrenaud, E. Davis, Ralph E. Yodaiken, L. Yanko, J. B. Herman, S. Duran Garcia, C. Jarrousse, J. Ditzel, Niels Peters Daugaard, Haakon Andersen, J. Egeberg, J. Nerup, O. O. Andersen, H. Kromann, G. Bendixen, J. E. Poulsen, E. Eschwege, S. Falkmer, S. O. Emdin, N. Havu, L. Winbladh Biuw, F. Sundby, J. F. Cutfield, S. M. Cutfield, G. G. Dodson, J. D. Peterson, D. F. Steiner, F. Fallucca, G. Menzinger, M. Iavicoli, G. Federspil, C. de Palo, E. Zago, D. Casara, M. Zaccaria, C. Scandellari, J. -P. Felber, G. Magnenat, B. Curchod, Ph. Pittet, N. Lytras, R. Müller-Hess, C. A. Geser, E. Jéquier, R. W. J. Flanagan, K. D. Buchanan, R. F. Murphy, Ivar Fölling, M. Fromantin, J. Freyria, F. Bressac, W. Geisthövel, U. Niedergerke, K. D. Morgner, B. Willms, H. J. Mitzkat, K. F. Gey, E. Bühler, P. Sommer, H. Georgi, H. Lengsfeld, D. Ghiea, E. Costiner, L. Simionescu, M. Oprescu, V. Grill, E. Cerasi, H. J. G. Gundersen, A. Gutman, J. Adler, D. Bar-Or, A. Gutzeit, B. Guy-Grand, B. Bigorie, Erik Gylfe, Lars-Åke Idahl, Margit Hamosh, Paul Hamosh, Adrian Hart, H. Cohen, J. M. Thorp, C. J. Hedeskov, K. Capito, B. Forruby, J. C. Henquin, A. B. Lambert, A. E. Lambert, K. D. Hepp, R. Renner, H. U. Häring, H. Mehnert, W. Kemmler, G. Löffler, A. Herchuelz, M. Mahy, Emilip Herrera, J. Garcia-Rafanell, J. Morell, Ch. Heuclin, B. H. Hicks, C. I. Taylor, S. K. Vij, S. Pek, R. F. Knopf, J. C. Floyd, S. S. Fajans, T. D. R. Hockaday, J. M. Hockaday, J. I. Mann, R. C. Turner, A. J. Honour, Y. Ikeda, S. Saito, Y. Matsuura, N. Obayashi, Y. Morimoto, T. Sano, M. Abe, R. Jacouot, J. M. Felix, C. Legrele, M. -Th. Sutter-Dub, B. Ch. J. Sutter, L. Kammerer, J. Fehér, J. Lévai, R. Dénes, M. Stützel, I. Balázsi, I. Láng, L. Littmann, C. Karakash, F. Assimacopoulos, N. Katsilambros, G. Papadopoulos, D. Varonos, G. Daikos, H. Keen, R. J. Jarrett, J. H. Fuller, N. H. K. Kiesselbach, W. Puls, U. Keup, Ryuichi Kikkawa, D. Duvillard, M. Ravazzola, W. Stauffacher, J. Köbberling, R. Kattermann, J. Kobberling, W. Creutzfeldt, Eva M. Kohner, A. M. Hamilton, G. F. Joplin, R. K. Blach, T. R. Fraser, H. J. Kolb, L. Weiss, O. H. Wieland, A. Korn, W. Waldhäusl, J. Bonelli, D. Magometsohnigg, G. Hitzenberger, Robert C. Kramp, G. J. Kremer, W. Atzpodien, B. Schnellbacher, B. Krug, P. Mialhe, R. Gross, R. Landgraf, M. Landgraf-Leurs, M. Klingenburg, I. Melamed, R. Hörl, István Láng Jun, László Littmann, Mária Stützel, Imre Balázsi, Derek R. Langslow, Keith D. Buchanan, Barry M. Freeman, Meir Berezin, I. Mincu, C. Dumitrescu, C. Ionescu-Tirgoviste, N. Mihalache, D. Boboia, J. Stanescu, E. Ghise-Beer, St. Georgescu, I. Bruckner, I. Popa, M. Muggeo, A. Tiengo, D. Padovan, M. Molinari, Walter A. Müller, Geoffrey W. G. Sharp

Publikováno v: Diabetologia. 10:357-400

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::101ba46ea21783ac1c33bfb9ff76efb6
https://doi.org/10.1007/bf02627739