Výsledky vyhledávání - "H. L. Pearce"

Anticancer drug development at Lilly Research Laboratories

Autor: H. L. Pearce

Publikováno v: Annals of Oncology. 6:S55-S62

Summary Background The discovery and clinical development of new drugs to treat cancer at Lilly Research Laboratories has undergone significant change during the past 15 years. During the early 1980s drug discovery relied heavily on a panel of syngen

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https://doi.org/10.1093/annonc/6.suppl_1.s55

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Synthesis of 4-Amino-8-(2, 2-Difluoro-2-Deoxy-β-D-Ribo Furanosyl Amino)Pyrimido [5, 4-D]Pyrimidine (dFARPP). Stability and Cellular Cytotoxicity

Autor: H. L. Pearce, J. M. Colacino, Chou Ta-Sen, C. D. Jones, T. E. Mabry, G. B. Grindey, J. F. Worzalla

Publikováno v: Nucleosides and Nucleotides. 13:1125-1133

The synthesis of β-dFARPP was accomplished by Mitsunobu coupling of 6-cyanopurine with 2-deoxy-2, 2-difluororibose followed by purine ring-expansion under the action of methanolic ammonia. The title compound inhibited the growth of proliferating hum

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https://doi.org/10.1080/15257779408011883

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ChemInform Abstract: Synthesis of 4-Amino-8-(2,2-difluoro-2-deoxy-β-D-ribofuranosyl amino)pyrimido(5,4-d)pyrimidine (DFARPP). Stability and Cellular Cytotoxicity

Autor: J. M. Colacino, H. L. Pearce, Chou Ta-Sen, Gerald B. Grindey, Chauncey D. Jones, John F. Worzalla, T. E. Mabry

Publikováno v: ChemInform. 26

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https://doi.org/10.1002/chin.199502206

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Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer

Autor: N, Suh, A L, Glasebrook, A D, Palkowitz, H U, Bryant, L L, Burris, J J, Starling, H L, Pearce, C, Williams, C, Peer, Y, Wang, M B, Sporn

Publikováno v: Cancer research. 61(23)

Arzoxifene ([6-hydroxy-3-[4-[2-(1-piperidinyl)-ethoxy]phenoxy]-2-(4-methoxyphenyl)]benzo[b]thiophene) is a selective estrogen receptor modulator (SERM) that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen ago

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https://pubmed.ncbi.nlm.nih.gov/11731420

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Preclinical, pharmacologic, and phase I studies of gemcitabine

Autor: A M, Storniolo, S R, Allerheiligen, H L, Pearce

Publikováno v: Seminars in oncology. 24(2 Suppl 7)

Gemcitabine (2',2'-difluorodeoxycytidine) is a novel nucleoside analogue that exerts its antitumor activity via multiple mechanisms of action. These include (1) incorporation of gemcitabine into replicating DNA, which inhibits DNA replication and cel

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https://pubmed.ncbi.nlm.nih.gov/9194473

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A structure-function relationship among reserpine and yohimbine analogues in their ability to increase expression of mdr1 and P-glycoprotein in a human colon carcinoma cell line

Autor: U G, Bhat, M A, Winter, H L, Pearce, W T, Beck

Publikováno v: Molecular pharmacology. 48(4)

We previously showed that there is a structure-function relationship among reserpine and yohimbine analogues in their ability to inhibit the function of P-glycoprotein (P-gp) and reverse multidrug resistance (MDR). Because some P-gp inhibitors (e.g.,

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https://pubmed.ncbi.nlm.nih.gov/7476894

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The crystal structure of 1,3,3,5-tetramethyl-6-(1',2'-naphtho)bicyclo[3,2,1]octenechromium(0) tricarbonyl

Autor: H. L. Pearce, R. C. Pettersen, M. J. Shapiro, B. L. Shapiro, D. L. Cullen

Publikováno v: Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 30:2360-2363

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https://doi.org/10.1107/s0567740874007126

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Lanthanide-induced shifts in proton nuclear magnetic resonance spectra. XI. Equilibrium constants and bound shifts for cyclohexanones and cyclohexanols

Autor: H. L. Pearce, T. W. Proulx, A. D. Godwin, M. D. Johnston, B. L. Shapiro, Michael J. Shapiro

Publikováno v: Journal of the American Chemical Society. 97:542-554

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https://doi.org/10.1021/ja00836a014

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1,3,3,5-Tetramethyl-6-(l',2'-naphtho)bicyclo[3.2.1]octene

Autor: D. L. Cullen, H. L. Pearce, R. C. Pettersen, B. L. Shapiro

Publikováno v: Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. 32:296-298

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https://doi.org/10.1107/s0567740876002847

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Thermodynamic analysis of the reaction of phosphoramide mustard with protector thiols

Autor: D E, Seitz, C J, Katterjohn, S M, Rinzel, H L, Pearce

Publikováno v: Cancer research. 49(13)

The systemic use of thiol-containing uroepithelial protecting agents, e.g., N-acetylcysteine (NAC) or mesna, in conjunction with the alkylating agent cyclophosphamide is predicated on the assumption that the toxic metabolic by-products will be consum

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https://pubmed.ncbi.nlm.nih.gov/2499418

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