Zobrazeno 1 - 10
of 172
pro vyhledávání: '"H. Kubinski"'
Publikováno v:
Mutation Research/Genetic Toxicology. 89:95-136
This report describes a novel technique for screening potential carcinogens and mutagens. The DNA-cell-binding (DCB) assay is based on earlier observations which indicated that DNA and other nucleic acids exposed to active carcinogens strongly react
Publikováno v:
Ecotoxicology and Environmental Safety. 6:9-18
Samples of articles, such as cleaning agents and personal hygiene products, found in patient hospital rooms or used in these areas were tested for their cancer-producing potential in a short-term, in vitro assay. The DNA cell-binding (DCB) test used
Autor:
H. Kubinski, Z. O. Kubinski
Publikováno v:
Toxicity Assessment. 1:387-406
The DNA-cell binding (DCB) assay grew from our early studies demonstrating that in the presence of carcinogenic chemicals, radioactively labeled nucleic acids attached strongly to isolated cellular membranes and to intact prokaryotic and eucaryotic c
Autor:
H. Kubinski, Olga Palacios
Publikováno v:
Cancer Letters. 14:323-328
An indirect exposure of mice during their fetal stage of development to Ehrlich ascites tumor cells alters the animals' response to this tumor during their adult life. Control mice injected intraperitoneally with Ehrlich tumor cells react in various
Publikováno v:
Ecotoxicology and Environmental Safety. 3:401-410
Materials used for cementing of orthodontic braces as well as the already “cured” polymer prepared with these materials were tested for their ability to react with nucleic acids in vitro and in living cells in tissue culture. In vitro assays indi
Publikováno v:
Carcinogenesis. 2:981-990
In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of indepen
Autor:
N.C. Morin, H. Kubinski
Publikováno v:
Ecotoxicology and Environmental Safety. 2:133-141
The two aqueous solutions used for production of residential home insulation by the so-called urea-formaldehyde process were tested for their ability to react with cellular macromolecules. One of the components (the catalyst-surfactant) changed the a
Autor:
H. Kubinski
Publikováno v:
Journal of Chromatography A. 197:236-239
Publikováno v:
Neuropharmacology. 13:111-117
Effects of neurotropic drugs on the formation of sodium dodecyl sulphate (SDS)—insoluble complexes between proteins and nucleic acids were investigated. Several drugs interfered with this reaction, either increasing or decreasing the final yield. C
Publikováno v:
Zeitschrift für Naturforschung B. 21:261-266
Suspended tissue culture cells incorporate 32P within 60 -90 min. into two high molecular weight RNA fractions which can be separated by chromatography on methylated serum albumin celite columns. One fraction contains mainly ribosomal precursor RNA.