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Akademický článek

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

Autor: Lauren Malave, Dustin R. Zuelke, Santiago Uribe-Cano, Lev Starikov, Heike Rebholz, Eitan Friedman, Chuan Qin, Qin Li, Erwan Bezard, Andreas H. Kottmann

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)

Lauren Malave et al. examine the impact of sonic hedgehog signaling in the dorsal striatum in L-Dopa induced dyskinesia (LID) animal models. Their results suggest that increasing sonic hedgehog signaling can reduce the severity of LID and abnormal in

Externí odkaz: https://doaj.org/article/531a7bf6b9d14cf6b23b49f1fe99cc48

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Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

Autor: Santiago Uribe-Cano, Andreas H. Kottmann, Lev Starikov, Dustin R Zuelke, Lauren Malave, Heike Rebholz, Chuan Qin, Erwan Bezard, Eitan Friedman, Qin Li

Publikováno v: Communications Biology
Communications Biology, Nature Publishing Group, 2021, 4 (1071), ⟨10.1038/s42003-021-02567-3⟩
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Communications Biology, 2021, 4 (1071), ⟨10.1038/s42003-021-02567-3⟩

L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminished sonic hedgehog (Shh) signaling in the basal g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3b77e96737f2da061a6071d9a64060
https://www.hal.inserm.fr/inserm-03352257

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Non-Destructive Evaluation of RPV Embrittlement by Means of the Thermoelectric Power Method

Autor: H. Kottmann, M. Niffenegger, D. F. Mora

Publikováno v: Volume 7: Non-Destructive Examination.

Nondestructive evaluation (NDE) methods are widely used for inspecting safety relevant components in nuclear reactors. Most of these NDE-methods are optimized and applied for the detection of cracks but there is still no reliable NDE method for measu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::416d798c1fbd9914aadb3944d2fd75ed
https://doi.org/10.1115/pvp2020-21446

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Publisher Correction: The Dopamine D5 receptor contributes to activation of cholinergic interneurons during L-DOPA induced dyskinesia

Autor: Marisol Cortés, Eitan Friedman, Lauren Malave, Heike Rebholz, Julia Castello, Andreas H. Kottmann, David R. Sibley

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc5fb20ded3d5793a852b6b09a9db1f
https://doi.org/10.1038/s41598-020-61832-3

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Dopaminergic Co-transmission with Sonic Hedgehog Inhibits Abnormal Involuntary Movements

Autor: Santiago Uribe-Cano, Dustin R Zuelke, Eitan Friedman, Lauren Malave, Andreas H. Kottmann, Erwan Bezard, Lev Starikov, Heike Rebholz, Chuan Qin, Qin Li

L-Dopa induced dyskinesia (LID) is a debilitating side effect of dopamine replacement therapy for Parkinson’s Disease. The mechanistic underpinnings of LID remain obscure. Here we report that diminshed sonic hedgehog (Shh) signaling in the basal ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::912a9434b4b7db8166c300a1177d6b10
https://doi.org/10.1101/2020.03.09.983759

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Diminished Ventral Oligodendrocyte Precursor Generation Results in the Subsequent Over-production of Dorsal Oligodendrocyte Precursors of Aberrant Morphology and Function

Autor: Andreas H. Kottmann, Lev Starikov

Publikováno v: Neuroscience. 450

Oligodendrocyte precursor cells (OPCs) arise sequentially first from a ventral and then from a dorsal precursor domain at the end of neurogenesis during spinal cord development. Whether the sequential production of OPCs is of physiological significan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e6bc626add0eba1dfc6002cf378aa8
https://pubmed.ncbi.nlm.nih.gov/32450295

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Akademický článek

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Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus

Autor: Chia Chu Chiang, Nicholas H. Couturier, Joshua Johnson, Jeffrey R. Capadona, Dominique Durand, Neha Reddy, Luis E. Gonzalez-Reyes, Lev Starikov, Manuel Arrillaga-Tamez, Mingming Zhang, Andreas H. Kottmann

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Scientific Reports

Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e953639bdaea3844f37ef0e37f1b237
https://doi.org/10.1038/s41598-019-53192-4

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Multiple sources of Shh are critical for the generation and scaling of ventral spinal cord oligodendrocyte precursor populations

Autor: Lev Starikov, Ghinia-Tegla M, Andreas H. Kottmann

Graded Sonic Hedgehog (Shh) signaling emanating from notochord and floorplate patterns the early neural tube. Soon thereafter, Shh signaling strength within the ventricular zone becomes dis-contiguous and discontinuous along the ventral to dorsal axi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82002d377e3567bdde4834bdbf28633

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