Zobrazeno 1 - 10
of 770
pro vyhledávání: '"H. Knowles"'
Autor:
Mary L. Venn, Charles H. Knowles, Elizabeth Li, James Glasbey, Dion G. Morton, Richard Hooper, ESCP EAGLE Safe Anastomosis Collaborative
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Large-scale quality improvement interventions demand robust trial designs with flexibility for delivery in different contexts, particularly during a pandemic. We describe innovative features of a batched stepped wedge trial, ESCP
Externí odkaz:
https://doaj.org/article/7b5cf296f46d4291bb662aaef08a88f2
Autor:
Charles H Knowles, Richard L Hooper, Dmitri Nepogodiev, Tom Pampiglione, Mary L Venn, Dion G Morton
Publikováno v:
BMJ Open, Vol 13, Iss 7 (2023)
Objective To systematically review preoperative and intraoperative Anastomotic Leak Prediction Scores (ALPS) and validation studies to evaluate performance and utility in surgical decision-making. Anastomotic leak (AL) is the most feared complication
Externí odkaz:
https://doaj.org/article/160835461a6a459f8967add5afdbf23a
Publikováno v:
Journal of Tissue Engineering, Vol 14 (2023)
Skeletal muscle-derived cells (SMDC) hold tremendous potential for replenishing dysfunctional muscle lost due to disease or trauma. Current therapeutic usage of SMDC relies on harvesting autologous cells from muscle biopsies that are subsequently exp
Externí odkaz:
https://doaj.org/article/16e3c6ff62854c10b56944c1415d1fe6
Autor:
Deborah D Stocken, Charles H Knowles, Roel Hompes, Neil Corrigan, Julie Cornish, Julie Croft, Alexandra Harriet Coxon-Meggy, Irene Vogel, Judith White, Alun Meggy, Deborah Keller, Aaron Quyn
Publikováno v:
BMJ Open, Vol 13, Iss 1 (2023)
Introduction Rectal cancer is common with a 60% 5-year survival rate. Treatment usually involves surgery with or without neoadjuvant chemoradiotherapy or adjuvant chemotherapy. Sphincter saving curative treatment can result in debilitating changes to
Externí odkaz:
https://doaj.org/article/ff82b6e72ce84535a63c8795c000ca2c
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269689 (2022)
BackgroundThe effect of ageing on total collagen content of human colon has been poorly investigated. The aim of this study was to determine if ageing altered total collagen content and distribution in the human colon.MethodsMacroscopically normal as
Externí odkaz:
https://doaj.org/article/2330909000ed4b42837bef258499dc67
Autor:
Charles H Knowles, Lesley Booth, Steve R Brown, Samantha Cross, Sandra Eldridge, Christopher Emmett, Ugo Grossi, Mary Jordan, Jon Lacy-Colson, James Mason, John McLaughlin, Rona Moss-Morris, Christine Norton, S Mark Scott, Natasha Stevens, Shiva Taheri, Yan Yiannakou
Publikováno v:
Programme Grants for Applied Research, Vol 9, Iss 14 (2021)
Background: Chronic constipation affects 1–2% of adults and significantly affects quality of life. Beyond the use of laxatives and other basic measures, there is uncertainty about management, including the value of specialist investigations, equipm
Externí odkaz:
https://doaj.org/article/96efbd1e0546422290b69f31ad9a2c81
Autor:
Alexandra Palmer, Sarah Epton, Ellie Crawley, Marilisa Straface, Luke Gammon, Meghan M. Edgar, Yichen Xu, Shezan Elahi, Joanne Chin-Aleong, Joanne E. Martin, Cleo L. Bishop, Charles H. Knowles, Gareth J. Sanger
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Human colonic neuromuscular functions decline among the elderly. The aim was to explore the involvement of senescence. A preliminary PCR study looked for age-dependent differences in expression of CDKN1A (encoding the senescence-related p21 protein)
Externí odkaz:
https://doaj.org/article/c1614b0af08f4e7a8d86d2f172e7060a
Autor:
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Intra-operative electrode placement for sacral neuromodulation (SNM) relies on visual observation of motor contractions alone, lacking complete information on neural activation from stimulation. This study aimed to determine whether electrophysiologi
Externí odkaz:
https://doaj.org/article/693e021480724f18b0bc585266aafa7d
Autor:
Lesley Dibley, Ailsa Hart, Julie Duncan, Charles H. Knowles, Sally Kerry, Doris Lanz, Vladislav Berdunov, Vichithranie W. Madurasinghe, Tiffany Wade, Helen Terry, Azmina Verjee, Mandy Fader, Christine Norton
Publikováno v:
Journal of Wound, Ostomy & Continence Nursing. 50:235-244
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0d631db27cad9921c05522fafe971d1
https://doi.org/10.1097/won.0000000000000979
https://doi.org/10.1097/won.0000000000000979
Publikováno v:
EClinicalMedicine, Vol 27, Iss , Pp 100572- (2020)
Background: In contrast to paediatric and geriatric populations, faecal incontinence and constipation in adults are generally considered separate entities. This may be incorrect. Methods: Cross-sectional study of consecutive patients (18–80 years)
Externí odkaz:
https://doaj.org/article/3f59b0f3b93b40cc83048f5935fc2959