Zobrazeno 1 - 10
of 116
pro vyhledávání: '"H. Kirk Hammond"'
Autor:
Pranav Dinesh Mathur, Junhuang Zou, Grace Neiswanger, Daniel Zhu, Yong Wang, Ali A. Almishaal, Deepti Vashist, H. Kirk Hammond, Albert H. Park, Jun Yang
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Adenylyl cyclase 6 (AC6) synthesizes second messenger cAMP in G protein-coupled receptor (GPCR) signaling. In cochlear hair cells, AC6 distribution relies on an adhesion GPCR, ADGRV1, which is associated with Usher syndrome (USH), a conditio
Externí odkaz:
https://doaj.org/article/d1181653922045a4994d88fa65149e00
Autor:
Young Song, Joseph Leem, Mehul Dhanani, M. Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O. Harrington, H. Kirk Hammond, David M. Roth, Hemal H. Patel
Publikováno v:
PLoS ONE, Vol 18, Iss 2 (2023)
Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during pathophysiological states that may impact cellular function and provide mechanistic insights to HF manage
Externí odkaz:
https://doaj.org/article/308d08b0074848d983fb435b6412f387
Autor:
Mei Hua Gao, Dimosthenis Giamouridis, N. Chin Lai, Tracy Guo, Bing Xia, Young Chul Kim, Viet Anh Nguyen Huu, Dorota Skowronska-Krawczyk, Louise Lantier, Raag Bhargava, H. Kirk Hammond
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 220-233 (2020)
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin
Externí odkaz:
https://doaj.org/article/828e78bc7b3643b49492393e8da28c44
Autor:
Dimosthenis Giamouridis, BS, MS, Mei Hua Gao, PhD, N. Chin Lai, PhD, Zhen Tan, PhD, Young Chul Kim, PhD, Tracy Guo, BS, Atsushi Miyanohara, PhD, W. Matthijs Blankesteijn, PhD, Erik Biessen, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 249-264 (2018)
Summary: UCn2 and UCn3 peptides have recently been infused to treat patients with heart failure (HF) but are limited by their short half-lives. A 1-time intravenous injection of virus vectors encoding UCn2 or UCn3 provided sustained increases in plas
Externí odkaz:
https://doaj.org/article/7f669bc55c904d3d97cf15fd9a30d1e9
Autor:
Mei Hua Gao, PhD, N. Chin Lai, PhD, Dimosthenis Giamouridis, MSc, Young Chul Kim, PhD, Zhen Tan, PhD, Tracy Guo, BS, Wolfgang H. Dillmann, MD, Jorge Suarez, PhD, H. Kirk Hammond, MD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 7, Pp 617-629 (2016)
Transgenic mice with cardiac-directed C1C2, a fusion protein of the intracellular C1 and C2 segments of adenylyl cyclase type 6, had normal left ventricular (LV) function, but diminished cAMP generation. Cardiac myocytes from C1C2 mice showed increas
Externí odkaz:
https://doaj.org/article/c3d4b2955ed24706befb04be3dee1927
Publikováno v:
Human Gene Therapy. 33:1091-1100
We used transverse aortic constriction (TAC) in mice to test the hypothesis thatiurocortin 2/i(iUcn2/i) gene transfer would increase left ventricular (LV) systolic and diastolic function in the pressure-stressed LV. Three groups were studied: (1) con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0499e632fa3dc48effbab55a8a54d4a
https://doi.org/10.1089/hum.2022.132
https://doi.org/10.1089/hum.2022.132
Autor:
Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)
IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo
Externí odkaz:
https://doaj.org/article/a76d1ce9339e432589e71472f8999c89
Autor:
Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218110 (2019)
PurposeWe previously reported that inhibitory G protein (Gi) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes of AC in the heart are AC5 and
Externí odkaz:
https://doaj.org/article/79ca3f0a931a43d6af8fdd3172083fc6
Autor:
Yasuhiro Ichikawa, Alice E Zemljic-Harpf, Zheng Zhang, M Dan McKirnan, Ana Maria Manso, Robert S Ross, H Kirk Hammond, Hemal H Patel, David M Roth
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177660 (2017)
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signali
Externí odkaz:
https://doaj.org/article/785157a1d7cc406e9698745e0dd63ed3
Autor:
Young Chul Kim, N. Chin Lai, Tracy Guo, Bing Xia, Zhenxing Fu, Mei Hua Gao, Dimosthenis Giamouridis, H. Kirk Hammond
Publikováno v:
Hum Gene Ther
Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated virus 8 encoding urocortin 2 (AAV8.UCn2) increases glucose disposal in models of insulin res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8568e785265894a596516b58eba06af1
https://doi.org/10.1089/hum.2018.150
https://doi.org/10.1089/hum.2018.150