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pro vyhledávání: '"H. Kay Chung"'
Multiomics atlas-assisted discovery of transcription factors enables specific cell state programming
Autor:
H. Kay Chung, Cong Liu, Eduardo Casillas, Brent Chick, Bryan Mcdonald, Jun Wang, Peixiang He, Ming Sun, Shixin Ma, Qiyuan Yang, Dan Chen, Filipe Hoffmann, Siva Karthik Varanasi, Victoria Tripple, Yuqing Hang, Ukrae H. Cho, Josephine Ho, April Williams, Yingxiao Wang, Diana Hargreaves, Susan M. Kaech, Wei Wang
Publikováno v:
bioRxiv
The same types of cells can assume diverse states with varying functionalities. Effective cell therapy can be achieved by specifically driving a desirable cell state, which requires the elucidation of key transcription factors (TFs). Here, we integra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa410dfe3083f8823ac951d14b75dd94
https://doi.org/10.1101/2023.01.03.522354
https://doi.org/10.1101/2023.01.03.522354
Autor:
Dan Chen, Siva Karthik Varanasi, Toshiro Hara, Kacie Traina, Bryan McDonald, Yagmur Farsakoglu, Josh Clanton, Shihao Xu, Thomas H. Mann, Victor Du, H. Kay Chung, Ziyan Xu, Victoria Tripple, Eduardo Casillas, Shixin Ma, Carolyn O’Connor, Qiyuan Yang, Ye Zheng, Tony Hunter, Greg Lemke, Susan M. Kaech
SummaryThe limited efficacy of immunotherapies against glioblastoma illustrates the urgent need to better understand the interactions between the central nervous system and the immune system. Here, we showed that a protective response to αCTLA-4 the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3960b3cb167bdea12b699cbc14958b
https://doi.org/10.1101/2022.08.12.502093
https://doi.org/10.1101/2022.08.12.502093
Autor:
Moujtaba Y. Kasmani, Ryan Zander, H. Kay Chung, Yao Chen, Achia Khatun, Martina Damo, Paytsar Topchyan, Kaitlin E. Johnson, Darya Levashova, Robert Burns, Ulrike M. Lorenz, Vera L. Tarakanova, Nikhil S. Joshi, Susan M. Kaech, Weiguo Cui
Publikováno v:
The Journal of experimental medicine. 220(1)
Although recent evidence demonstrates heterogeneity among CD8+ T cells during chronic infection, developmental relationships and mechanisms underlying their fate decisions remain incompletely understood. Using single-cell RNA and TCR sequencing, we t
Autor:
H. Kay Chung, Michael Z. Lin
Publikováno v:
Nature Methods. 17:885-896
Sequence-specific proteases have proven to be versatile building blocks for tools that report or control cellular function. Reporting methods link protease activity to biochemical signals, whereas control methods rely on engineering proteases to resp
Publikováno v:
The Journal of Experimental Medicine
Chung et al. discuss the architectural design of CD8+ T cell responses during acute and chronic viral infection, emphasizing the parallelism of the differentiation pathways, the heterogeneity of the resultant T cell states, and the underlying transcr
Akademický článek
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