A microglia-CD4+ T cell partnership generates protective anti-tumor immunity to glioblastoma

Autor: Dan Chen, Siva Karthik Varanasi, Toshiro Hara, Kacie Traina, Bryan McDonald, Yagmur Farsakoglu, Josh Clanton, Shihao Xu, Thomas H. Mann, Victor Du, H. Kay Chung, Ziyan Xu, Victoria Tripple, Eduardo Casillas, Shixin Ma, Carolyn O’Connor, Qiyuan Yang, Ye Zheng, Tony Hunter, Greg Lemke, Susan M. Kaech

SummaryThe limited efficacy of immunotherapies against glioblastoma illustrates the urgent need to better understand the interactions between the central nervous system and the immune system. Here, we showed that a protective response to αCTLA-4 the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b3960b3cb167bdea12b699cbc14958b
https://doi.org/10.1101/2022.08.12.502093

On the cutting edge: protease-based methods for sensing and controlling cell biology

Autor: H. Kay Chung, Michael Z. Lin

Publikováno v: Nature Methods. 17:885-896

Sequence-specific proteases have proven to be versatile building blocks for tools that report or control cellular function. Reporting methods link protease activity to biochemical signals, whereas control methods rely on engineering proteases to resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a1b83d99aca4a0417805847f60ecd0
https://doi.org/10.1038/s41592-020-0891-z

Transformable Gel-to-Nanovaccine Enhances Cancer Immunotherapy via Metronomic-Like Immunomodulation and Collagen-Mediated Paracortex Delivery.

Autor: Jin SM; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Cho JH; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Gwak Y; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Park SH; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Choi K; Progeneer, 12 Digital-ro 31-gil, Guro-gu, Seoul, 08380, Republic of Korea., Choi JH; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Shin HS; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Hong J; Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Bae YS; Department of Biological Sciences, Science Research Center (SRC) for Immune Research on Non-lymphoid Organ (CIRNO), Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Ju J; Department of Biomedical Engineering, Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Shin M; Department of Biomedical Engineering, Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea., Lim YT; SKKU Advanced Institute of Nanotechnology (SAINT), Department of Nano Engineering, Department of Nano Science and Technology, School of Chemical Engineering, and Biomedical Institute for Convergence at SKKU, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Oct 09, pp. e2409914. Date of Electronic Publication: 2024 Oct 09.

New Glioblastomas Study Findings Recently Were Reported by Researchers at Salk Institute for Biological Studies (Ctla-4 Blockade Induces a Microglia-th1 Cell Partnership That Stimulates Microglia Phagocytosis and Anti-tumor Function In...).

Publikováno v: Immunotherapy Weekly; 10/31/2023, p782-782, 1p