Zobrazeno 1 - 10
of 29
pro vyhledávání: '"H. Kaspar Binz"'
Autor:
Andreas Plückthun, Robert Waibel, H. Kaspar Binz, Roger Schibli, Birgit Dreier, Gabriela Nagy-Davidescu, Rastislav Tamaskovic, Christine de Pasquale, Michael T. Stumpp, Martin Kawe, Christian Zahnd
Supplementary Materials, Table 1-6, Figures 1-10 from Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a929f6f45cc62b35a0d4b774e9ce3
https://doi.org/10.1158/0008-5472.22387148.v1
https://doi.org/10.1158/0008-5472.22387148.v1
Publikováno v:
BioDrugs. 34:423-433
The DARPin® drug platform was established with a vision to expand the medical use of biologics beyond what was possible with monoclonal antibodies. It is based on naturally occurring ankyrin repeat domains that are typically building blocks of multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e34e0e101671b4cb1964604366c52b94
https://doi.org/10.1007/s40259-020-00429-8
https://doi.org/10.1007/s40259-020-00429-8
Autor:
Sylvia Rothenberger, Daniel L. Hurdiss, Marcel Walser, Francesca Malvezzi, Jennifer Mayor, Sarah Ryter, Hector Moreno, Nicole Liechti, Andreas Bosshart, Chloe Iss, Valérie Calabro, Andreas Cornelius, Tanja Hospodarsch, Alexandra Neculcea, Thamar Looser, Anja Schlegel, Simon Fontaine, Denis Villemagne, Maria Paladino, Yvonne Kaufmann, Doris Schaible, Iris Schlegel, Dieter Schiegg, Christof Zitt, Gabriel Sigrist, Marcel Straumann, Feyza Sacarcelik, Julia Wolter, Marco Comby, Julia M. Adler, Kathrin Eschke, Mariana Nascimento, Azza Abdelgawad, Achim D. Gruber, Judith Bushe, Olivia Kershaw, Heyrhyoung Lyoo, Chunyan Wang, Wentao Li, Ieva Drulyte, Wenjuan Du, H. Kaspar Binz, Rachel Herrup, Sabrina Lusvarghi, Sabari Nath Neerukonda, Russell Vassell, Wei Wang, Susanne Mangold, Christian Reichen, Filip Radom, Charles G. Knutson, Kamal K. Balavenkatraman, Krishnan Ramanathan, Seth Lewis, Randall Watson, Micha A. Haeuptle, Alexander Zürcher, Keith M. Dawson, Daniel Steiner, Carol D. Weiss, Patrick Amstutz, Frank J.M. van Kuppeveld, Michael T. Stumpp, Berend-Jan Bosch, Olivier Engler, Jakob Trimpert
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has so far infected more than 160 million people globally, and continues to undergo genomic evolution. Emerging SARS-CoV-2 variants show increased infectivity and may lead to resistance again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f1f2736c93ea65c719bd52f33d283d1
https://doi.org/10.1101/2021.02.03.429164
https://doi.org/10.1101/2021.02.03.429164
Autor:
Douglas Phillips, Christof Zitt, Thomas Göttler, Savira Ekawardhani, Ignacio Dolado, Gabriel Sigrist, Michael T. Stumpp, Karl G. Proba, Ulrike Fiedler, H. Kaspar Binz, Talitha Bakker, Andreas Cornelius, Johan Abram Saliba, Gaby Tresch
Publikováno v:
mAbs. 9(8)
MP0250 is a multi-domain drug candidate currently being tested in clinical trials for the treatment of cancer. It comprises one anti-vascular endothelial growth factor-A (VEGF-A), one anti-hepatocyte growth factor (HGF), and two anti-human serum albu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14630bc2592e16f419a4a0925dfa413f
https://pubmed.ncbi.nlm.nih.gov/29035637
https://pubmed.ncbi.nlm.nih.gov/29035637
We describe here the rapid selection of specific MAP-kinase binders from a combinatorial library of designed ankyrin repeat proteins (DARPins). A combined in vitro/in vivo selection approach, based on ribosome display and the protein fragment complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0cdd1e564d91490448ec61a06ff022
http://doc.rero.ch/record/297682/files/gzl004.pdf
http://doc.rero.ch/record/297682/files/gzl004.pdf
Autor:
Michael T. Stumpp, Ivo Sonderegger, H. Kaspar Binz, Douglas Phillips, Maya Gulotti-Georgieva, Patrik Forrer, Daniel Steiner, Denis Villemagne, Christof Zitt, Frieder W. Merz
Publikováno v:
Protein engineering, designselection : PEDS. 30(9)
A long systemic half-life is key for therapeutic proteins. To that end we have generated serum albumin-binding designed ankyrin repeat domains. These domains bind serum albumin of different species with nanomolar affinities, and have significantly im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda304704d3ca688cb9dda6719e0dd75
https://pubmed.ncbi.nlm.nih.gov/29088432
https://pubmed.ncbi.nlm.nih.gov/29088432
Autor:
Johan Abram Saliba, Denis Villemagne, Caroline A. C. Hyde, Alexandra Giese, Kurt Ballmer-Hofer, Thomas Schleier, H. Kaspar Binz, Edward Stuttfeld
Publikováno v:
Molecular and cellular biology
Vascular endothelial growth factors (VEGFs) activate three receptor tyrosine kinases, VEGFR-1, -2, and -3, which regulate angiogenic and lymphangiogenic signaling. VEGFR-2 is the most prominent receptor in angiogenic signaling by VEGF ligands. The ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fe4121f33f72904d91bd26e1b214b7
Autor:
S. Miranda, Peter Donner, M. A. A. Thomaz, Roman Hillig, Vera Pütter, Caterina Holz, Jörg Fanghänel, Uwe Eberspaecher, Maria Arménia Carrondo, Pedro M. Matias, Patrick Amstutz, Christine Lang, Kerstin Crusius, Maya Gulotti-Georgieva, Beate Muller-Tiemann, H. Kaspar Binz, Ursula Egner, Tiago M. Bandeiras, Arndt Schmitz
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 64:339-353
As a key regulator of mitosis, the Ser/Thr protein polo-like kinase-1 (Plk-1) is a well validated drug target in cancer therapy. In order to enable structure-guided drug design, determination of the crystal structure of the kinase domain of Plk-1 was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f8b5b6e2a5898f1e802d4480ee6e5b
https://doi.org/10.1107/s0907444907068217
https://doi.org/10.1107/s0907444907068217
Autor:
Antonio Baici, Eva Prenosil, Heidi Roschitzki-Voser, Markus G. Grütter, Andreas Plückthun, Guido Capitani, Patrick Amstutz, Maya Gulotti-Georgieva, H. Kaspar Binz, Christophe Briand, Andreas Schweizer
Publikováno v:
Structure. 15:625-636
SummarySpecific and potent caspase inhibitors are indispensable for the dissection of the intricate pathways leading to apoptosis. We selected a designed ankyrin repeat protein (DARPin) from a combinatorial library that inhibits caspase-2 in vitro wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13583e650b08c37e0eabc32fbce874ba
https://doi.org/10.1016/j.str.2007.03.014
https://doi.org/10.1016/j.str.2007.03.014
Autor:
Markus G. Grütter, Andreas Kohl, Patrik Forrer, Patrick Amstutz, Petra Parizek, Michael T. Stumpp, Andreas Plückthun, H. Kaspar Binz
Publikováno v:
Journal of Biological Chemistry. 280:24715-24722
The specific intracellular inhibition of protein activity at the protein level allows the determination of protein function in the cellular context. We demonstrate here the use of designed ankyrin repeat proteins as tailor-made intracellular kinase i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40d6ff92077511d2f6122501b50a499
https://doi.org/10.1074/jbc.m501746200
https://doi.org/10.1074/jbc.m501746200