Zobrazeno 1 - 10
of 36
pro vyhledávání: '"H. Karel Nieuwenhuis"'
Publikováno v:
Blood Coagulation & Fibrinolysis. 14:557-562
Tissue factor-induced coagulation leads to the generation of a small amount of thrombin, resulting in the formation of a fibrin clot. After clot formation, thrombin generation continues resulting in the activation of thrombin activatable fibrinolysis
Autor:
Rob Fijnheer, H. Karel Nieuwenhuis, Birgit Paijmans, Mark Roest, Leo F. Verdonck, A. W. Dekker
Publikováno v:
British Journal of Haematology. 118:267-270
Summary. Subclavian vein thrombosis is a well-recognized complication following central venous catheter insertion and is associated with significant morbidity. The factor V Leiden mutation is an important risk factor for deep venous thrombosis and pu
Autor:
Roger E. G. Schutgens, H. Karel Nieuwenhuis, Fred J. L. M. Haas, Douwe H. Biesma, Earl U. Esseboom
Publikováno v:
The American Journal of Medicine. 112:617-621
Purpose The D-dimer test is used commonly in diagnostic strategies to reduce the need for ultrasonography in patients suspected of having deep venous thrombosis. We studied several clinical and laboratory variables that might limit the accuracy of a
Autor:
Philip G. de Groot, Jan van der Meer, Frank W.G. Leebeek, H. Karel Nieuwenhuis, Karina Meijer, Ton Lisman
Publikováno v:
Hepatology. 35:616-621
Cirrhosis is associated with a bleeding tendency, which is particularly pronounced during orthotopic liver transplantation (OLT). A novel approach to treating the bleeding diathesis of patients with cirrhosis is administration of recombinant factor V
Autor:
Hanneke M. van der Straaten, Rob Fijnheer, A. W. Dekker, Leo F. Verdonck, H. Karel Nieuwenhuis
Publikováno v:
British Journal of Haematology. 114:31-35
The success of allogeneic bone marrow transplantation (BMT) is limited by the major complications, graft-versus-host disease (GVHD) and relapse. The very beneficial effect of maximal T-cell depletion of the graft for prevention of GVHD has been count
Publikováno v:
Thrombosis and Haemostasis. 86:887-893
SummaryGMP-33 is a platelet membrane associated protein that is recognised by RUU-SP 1.77, an antibody raised against activated platelets. GMP-33 is predominantly associated with the membrane of platelet α-granules and it is translocated to the plas
Autor:
Jan-Willem N. Akkerman, Barbara Franke, H. Karel Nieuwenhuis, Miranda van Triest, Johannes L. Bos, Gijsbert van Willigen, Claude Negrier, Kim M. T. de Bruijn
Publikováno v:
ResearcherID
Rap1, a small GTPase of the Ras family, is ubiquitously expressed and particularly abundant in platelets. Previously we have shown that Rap1 is rapidly activated after stimulation of human platelets with alpha-thrombin. For this activation, a phospho
Publikováno v:
Blood. 90:4201-4205
Patients with recurrent or refractory low-grade non-Hodgkin's lymphoma (NHL) are increasingly treated with myeloablative therapy and autologous stem cell transplantation. However, allogeneic bone marrow transplantation (BMT) is only sporadically perf
Autor:
Marja van Vliet, Ronald H. W. M. Derksen, Godelieve C.M.L. Christiaens, H. Karel Nieuwenhuis, Hein W. Bruinse, Henk J. Out, Philip G. de Groot
Publikováno v:
American Journal of Obstetrics and Gynecology. 167:26-32
Objectives: A prospective, controlled multicenter study was performed to estimate the obstetric risks of antiphospholipid antibodies (the lupus anticoagulant and anticardiolipin antibodies). In addition, the risks of prior thrombosis, obstetric histo
Publikováno v:
Thrombosis and Haemostasis. 66:700-707
SummaryThe platelet plasma membrane expresses several membrane glycoproteins with a high molecular weight. In this study we have investigated the properties of the CD31 antigen on platelets and endothelial cells using the monoclonal antibody (MoAb) R