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A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

Autor: K, Paz, R, Hemi, D, LeRoith, A, Karasik, E, Elhanany, H, Kanety, Y, Zick

Publikováno v: The Journal of biological chemistry. 272(47)

Tumor necrosis factor alpha (TNFalpha) or chronic hyperinsulinemia that induce insulin resistance trigger increased Ser/Thr phosphorylation of the insulin receptor (IR) and of its major insulin receptor substrates, IRS-1 and IRS-2. To unravel the mol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6373a905937dbf6ec05beee722c79ff8
https://pubmed.ncbi.nlm.nih.gov/9368067

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Akademický článek

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Insulin-like growth factor I and its binding proteins 3 and 4 are increased in Human inflammatory synovial fluid

Autor: H, Kanety, I, Shimon, M, Ehrenfeld, A, Israeli, C, Pariente, A, Karasik

Publikováno v: The Journal of rheumatology. 23(5)

To measure insulin-like growth factor I (IGF-I) and its binding proteins (IGFBP) in human synovial fluid (SF), as IGF-I resistance in the chondrocyte was implicated in the pathogenesis of inflammatory arthritis.Ten patients with inflammatory arthriti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69b33b8dd4ba060c4ecd48341d8ea469
https://pubmed.ncbi.nlm.nih.gov/8724290

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Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

Autor: H, Kanety, R, Feinstein, M Z, Papa, R, Hemi, A, Karasik

Publikováno v: The Journal of biological chemistry. 270(40)

Tumor necrosis factor-alpha (TNF) has been suggested to be the mediator of insulin resistance in infection, tumor cachexia, and obesity. We have previously shown that TNF diminishes insulin-induced tyrosine phosphorylation of insulin receptor substra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79d9d48b8fab614b58293192262574d9
https://pubmed.ncbi.nlm.nih.gov/7559552

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A cytosolic protein tyrosine kinase activity is induced by follicle stimulating hormone and insulin like growth factor-I in human granulosa cells

Autor: N. Costrici, A Karasik, Bruno Lunenfeld, J Dor, C Pariente, H Kanety, G Elberg

Publikováno v: Endocrinology. 136(10)

Follicle stimulating hormone (FSH) induces estradiol (E2) production in rat, porcine and human granulosa cells with a concomitant increase in cAMP. In human granulosa cells insulin like growth factor-I (IGF-I) induces E2 production without cAMP accum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fc287e85e4bdc4c7f632be080694e2
https://pubmed.ncbi.nlm.nih.gov/7664693

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Ghrelin, adiponectin and leptin in cancer cachexia

Autor: Siegal Sadetzki, C. Pariente, Bernice Oberman, Yulia Kundel, I. Shimon, Bella Kaufman, H. Kanety, Ido Wolf, Raphael Catane

Publikováno v: Journal of Clinical Oncology. 23:8113-8113

8113 Background: The hormone ghrelin and the adipocytokines leptin and adiponectin participate in body weight regulation. In response to severe weight loss, ghrelin and adiponectin levels increase ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f14985a381bc86edfe5ee06e15e4af7
https://doi.org/10.1200/jco.2005.23.16_suppl.8113

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