Zobrazeno 1 - 10
of 113
pro vyhledávání: '"H. Kalervo Väänänen"'
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18689 (2011)
It has been widely believed that the cytokines required for osteoclast formation are M-CSF (also known as CSF-1) and RANKL. Recently, a novel cytokine, designated IL-34, has been identified as another ligand of CSF1R. This study was to explore the bi
Externí odkaz:
https://doaj.org/article/b7bd75dcf9df4762a530142bb2598d85
Publikováno v:
Tissue Engineering Part C Methods. 18(9):658-666
The development of in vitro culturing techniques for osteoblastic differentiation of human mesenchymal stem cells (hMSC) is important for cell biology research and the development of tissue-engineering applications. Dexamethasone (Dex) is a commonly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c199919bc11f655a41a4fbee6557935c
https://doi.org/10.1089/ten.TEC.2011.0675
https://doi.org/10.1089/ten.TEC.2011.0675
Autor:
Mirkka J. Hirvonen, H. Kalervo Väänänen, Mika T. K. Mulari, Pirkko L. Härkönen, Kálmán G. Büki, Pirkko Vihko
Publikováno v:
Journal of Histochemistry & Cytochemistry. 6(7):537-549
Osteoclasts are bone-resorbing multinucleated cells that undergo drastic changes in their polarization due to heavy vesicular trafficking during the resorption cycle. These events require the precise orchestration of membrane traffic in order to main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4226ded75e416234392ef41f3ed318
https://doi.org/10.1369/0022155412448069
https://doi.org/10.1369/0022155412448069
Autor:
Jonas Nyman, H. Kalervo Väänänen
Publikováno v:
Calcified Tissue International. 87:273-283
Osteoclastic bone resorption can be completely abolished by inhibiting the vacuolar H(+)-ATPase (V-ATPase), a proton pump composed of at least 12 different subunits. However, V-ATPases are ubiquitous and it is unclear whether the osteoclast V-ATPase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01cc99f421b07c61dded7679c4fc59ad
https://doi.org/10.1007/s00223-010-9395-7
https://doi.org/10.1007/s00223-010-9395-7
Publikováno v:
Journal of Bone and Mineral Research. 6:1091-1097
Bone resorption is a multistep process that includes the maturation of osteoclast precursors, the special attachment of fully differentiated osteoclasts to mineralized bone surface, and the dissolution of inorganic mineral, as well as the breakdown o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afce75ab05e47957debe38234674ea0d
https://doi.org/10.1002/jbmr.5650061010
https://doi.org/10.1002/jbmr.5650061010
Publikováno v:
Technology and Health Care. 17(1):49-56
Microdamage in bone contributes to fractures and acts as a stimulus for bone remodeling. Osteocytes are the most abundant cells in bone, and their death by microdamage has been suggested to be the major event leading in the initiation of osteoclastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed194e5171df5de1975e704ca1997ec6
http://hdl.handle.net/2324/1955407
http://hdl.handle.net/2324/1955407
Autor:
H. Kalervo Väänänen, Hannele Ylipahkala, Jussi M. Halleen, Jukka P. Rissanen, Katja M. Fagerlund, Clive Long
Publikováno v:
Journal of Bone and Mineral Metabolism. 27:105-109
We cultured human bone marrow-derived stem cells on bovine bone slices in 96-well plates in the presence of M-CSF and RANKL, allowing them to differentiate into osteoclasts. Secreted TRACP 5b was a useful endpoint measurement to demonstrate effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3cf5c88145b884d39e777ef2407756
https://doi.org/10.1007/s00774-008-0002-1
https://doi.org/10.1007/s00774-008-0002-1
Autor:
Kristina Åkesson, H. Kalervo Väänänen, Janaka Lenora, Paul Gerdhem, Karl J Obrant, Kaisa K. Ivaska
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 93:2622-2632
One of the important challenges in the management of osteoporosis is to identify women who are at high risk of developing osteoporosis and fragility fractures.Our objective was to evaluate whether assessment of bone metabolism at multiple occasions c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10a2560d26b4e1bba88619b3065077f
https://doi.org/10.1210/jc.2007-1508
https://doi.org/10.1210/jc.2007-1508
Autor:
Anu Kallio, H. Kalervo Väänänen, Jani Seppänen, Tao Guo, Elisa Lamminen, Pirkko Härkönen, Lauri Kangas
Publikováno v:
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology, Elsevier, 2008, 289 (1-2), pp.38. ⟨10.1016/j.mce.2008.03.005⟩
Molecular and Cellular Endocrinology, Elsevier, 2008, 289 (1-2), pp.38. ⟨10.1016/j.mce.2008.03.005⟩
In the current work, we compared the ability of 17beta-estradiol (E2) and the selective estrogen receptor modulators (SERMs), tamoxifen (Tam), raloxifene (Ral) and ospemifene (Osp) to promote the survival of osteoblast-derived cells against etoposide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c92579c5d8630a19155f3e404b33cf
https://doi.org/10.1016/j.mce.2008.03.005
https://doi.org/10.1016/j.mce.2008.03.005
Autor:
Yi Sun, Tiina Laitala-Leinonen, Martin Nars, Tuula Kaisto, Mika T.K. Mulari, Kalervo Metsikkö, H. Kalervo Väänänen
Publikováno v:
Experimental Cell Research. 314:1641-1651
Transcytotic membrane flow delivers degraded bone fragments from the ruffled border to the functional secretory domain, FSD, in bone resorbing osteoclasts. Here we show that there is also a FSD-to-ruffled border trafficking pathway that compensates f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b365d3233eb8710e4c75b7575b34e378
https://doi.org/10.1016/j.yexcr.2008.02.011
https://doi.org/10.1016/j.yexcr.2008.02.011