Výsledky vyhledávání - "H. K. Kroemer"

A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma

Autor: Robin D. Tucker, Victor Ciofoaia, Sandeep Nadella, Martha D. Gay, Hong Cao, Matthew Huber, Anita Safronenka, Narayan Shivapurkar, Bhaskar Kallakury, Annie J. Kruger, Alexander H. K. Kroemer, Jill P. Smith

Publikováno v: Digestive Diseases and Sciences

Background and Aims Nonalcoholic steatohepatitis (NASH) is a common inflammatory liver condition that may lead to cirrhosis and hepatocellular carcinoma (HCC). Risk factors for NASH include a saturated fat diet, altered lipid metabolism, and genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7407e148477a93fe9ee18499547a73f7
https://pubmed.ncbi.nlm.nih.gov/31297627

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The growth hormone—IGF-I axis as a mediator for the association between FTO variants and body mass index: results of the Study of Health in Pomerania

Autor: Hans-Jörgen Grabe, T. Kocher, Alexa Bornhorst, M. Mischke, Christian Schwahn, Nele Friedrich, Johannes Hebebrand, H. K. Kroemer, F. Neumann, Matthias Nauck, Dieter Rosskopf, Christian Rimmbach, Henri Wallaschofski, Henry Völzke, I. Geissler, S. Wolf

Publikováno v: International Journal of Obesity. 35:364-372

Risk alleles of the fat mass- and obesity-associated gene (FTO) are related not only to increased body mass index (BMI) values but also to mortality. It was speculated that cellular effects of the FTO gene affect most organs, especially their ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f305193f9aa39ab741bcc86e82b6a74
https://doi.org/10.1038/ijo.2010.158

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Optimized adeno-associated virus 8 produces hepatocyte-specific Cre-mediated recombination without toxicity or affecting liver regeneration

Autor: Alexander H. K. Kroemer, Chunyan Ma, Caroline E. Bass, Ernest Terwilliger, Karen J. Ho, Seth J. Karp

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G412-G419

Engineering viral vectors to produce liver-specific protein expression may help advance understanding of hepatic regeneration and disease states. In addition to introducing genes of interest to the liver, these vectors can be adapted for gene deletio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a057fa413311b1acbc41818f0e01ac46
https://doi.org/10.1152/ajpgi.00590.2007

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Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex

Autor: S, Haenisch, U, Zimmermann, E, Dazert, C J, Wruck, P, Dazert, W, Siegmund, S, Siegmund, H K, Kroemer, R W, Warzok, I, Cascorbi

Publikováno v: The Pharmacogenomics Journal. 7:56-65

There is increasing evidence that polymorphisms of the adenosine 5' triphosphate membrane transporters ABCB1 (P-glycoprotein, MDR1) may affect expression and function, whereas less information is available about the impact of ABCC2 (multidrug resista

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab47973e84df3a6150a3294b1fa78994
https://doi.org/10.1038/sj.tpj.6500403

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Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

Autor: H. K. Kroemer, Thorsten J. Maier, Dana Dressel, James F. Beck, Thomas Klingebiel, Werner Siegmund, Bernhard Sperker, Christoph A. Ritter, Markus Grube

Publikováno v: Dressel, D, Ritter, C A, Sperker, B, Grube, M, Maier, T, Klingebiel, T, Siegmund, W, Beck, J F & Kroemer, H K 2003, ' Busulfan induces activin A expression in vitro and in vivo : a possible link to venous occlusive disease ' Clinical Pharmacology and Therapeutics, vol. 74, no. 3, pp. 264-74 . https://doi.org/10.1016/S0009-9236(03)00190-5

Purpose Hepatic venous occlusive disease is a severe side effect after administration of busulfan before hematopoietic stem cell transplantation. The syndrome is characterized by liver enlargement, fluid retention, jaundice, and weight gain. Endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1393d678c21c9aad9c638dfdf9fd1b42
https://doi.org/10.1016/s0009-9236(03)00190-5

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Pharmakokinetik von Cyclo-phosphamid, Adriamycin und Adramycin-Prodrug (HMR 1826) im ex-vivo-isolierten perfundierten humanen Lungenresektionsmodell (IHLP)1

Autor: Peter Fritz, H. K. Kroemer, H. Toomes, M. McClellan, Thomas E. Mürdter, A. Linder, Lutz Freitag, Godehard Friedel, F. Bohnenstengel, B. Sperker

Publikováno v: Pneumologie. 54:494-498

BACKGROUND Today knowledge about pharmacokinetics of anticancer drugs in human malignant tumors is poor. Data from in vivo studies are limited and difficult to obtain due to ethical aspects. An ex vivo isolated perfused and ventilated human lung mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7efd8264d7638fe5ec8f845ff93efc99
https://doi.org/10.1055/s-2000-8250

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