Výsledky vyhledávání - "H. K. ÅKERBLOM"

Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group

Autor: Outi Vaarala, Suvi M. Virtanen, Erkki Savilahti, Mikael Knip, Jorma Ilonen, Johanna Paronen, H. K. Åkerblom

Publikováno v: Diabetes. 49:1657-1665

Type 1 diabetes is considered to be a T-cell-mediated autoimmune disease in which insulin-producing beta-cells are destroyed. Immunity to insulin has been suggested to be one of the primary autoimmune mechanisms leading to islet cell destruction. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba51f2b6ffa402b93d96488fca6c1285
https://doi.org/10.2337/diabetes.49.10.1657

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Cow's milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes

Autor: Anu-Maaria Hämäläinen, H. K. Åkerblom, Outi Vaarala, Mikael Knip, Jorma Ilonen, Olli Simell, Päivi Muona, Johanna Paronen, Minna Väätäinen

Publikováno v: Diabetes. 48:1389-1394

Insulin autoantibodies (IAAs) often appear as the first sign of islet cell autoimmunity in prediabetic children. Because cow's milk contains bovine insulin, we followed the development of insulin-binding antibodies in children fed with cow's milk for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d01514928f4a2bf008a99b961556113
https://doi.org/10.2337/diabetes.48.7.1389

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Cow’s milk consumption, disease-associated autoantibodies and Type 1 diabetes mellitus: a follow-up study in siblings of diabetic children

Autor: Elina Hyppönen, Suvi M. Virtanen, Mikael Knip, H. K. Åkerblom, Esa Läärä, Leena Räsänen, K. Savola, Paula Vähäsalo, Petri Kulmala, A Aro

Publikováno v: Diabetic Medicine. 15:730-738

Evidence from case-control studies for the diabetogenicity of introduction of cow's milk-based formulas at early age in infancy is inconclusive. We followed siblings of children with Type 1 diabetes mellitus (Type 1 DM) to investigate a possible rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9311083c8d19d160a027427dea5155d4
https://doi.org/10.1002/(sici)1096-9136(199809)15:9<730::aid-dia646>3.0.co

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Putative environmental factors in Type 1 diabetes

Autor: H. K. Åkerblom, Mikael Knip

Publikováno v: Diabetes / Metabolism Reviews. 14:31-68

Various environmental triggers, e.g. certain viruses and dietary factors, are thought to initiate the autoimmune process, leading to the destruction of pancreatic β-cells and consequent Type 1 diabetes. A genetic predisposition is another prerequisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a94ca98a88d23d2f7b020493bd537b6
https://doi.org/10.1002/(sici)1099-0895(199803)14:1<31::aid-dmr201>3.0.co

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Significance of cow's milk protein antibodies as risk factor for childhood IDDM: interactions with dietary cow's milk intake and HLA-DQB1 genotype

Autor: H. K. Åkerblom, M. Karppinen, Leena Räsänen, Helena Reijonen, Suvi M. Virtanen, Tero Saukkonen, Jorma Ilonen, Emma M. Savilahti

Publikováno v: Diabetologia. 41:72-78

Dietary factors are suspected to play an aetiological role in the development of insulin-dependent diabetes mellitus (IDDM). We analysed cow's milk formula, betalactoglobulin, and bovine serum albumin antibodies by an enzyme-linked immunoassay in uns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7da8fd2e58fd6d2ce28c38e0518027d4
https://doi.org/10.1007/s001250050869

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Disease-Associated Antibodies in Offspring of Mothers with IDDM

Autor: Kari Teramo, H. K. Åkerblom, Tero Saukkonen, Mikael Knip, Anu Martikainen, Helena Reijonen, Jorma Ilonen, Pentti Koskela, Petri Kulmala

Publikováno v: Diabetes. 45:1706-1710

We studied 20 infants of mothers with IDDM participating in a pilot study for a dietary intervention trial, testing the hypothesis that avoidance of cow's milk proteins early in life will reduce the risk of subsequent IDDM. The aim was to evaluate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e1c3429865e9aa7536a6e9480422b4
https://doi.org/10.2337/diab.45.12.1706

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Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study

Autor: Tuija Poussa, Outi Vaarala, Jorma Komulainen, H. K. Åkerblom, Terhi Ruohtula, Anna-Liisa Järvenpää, Mikael Knip, Matti Koski, Suvi M. Virtanen, R Lounamaa, Olli Tossavainen, Jouni Pesola, Harri Kallioinen, Jorma Ilonen, Taina Härkönen

Publikováno v: Archives of pediatricsadolescent medicine. 166(7)

OBJECTIVE To test whether weaning to a bovine insulin-free cow's milk formula (CMF) reduces type 1 diabetes mellitus-associated autoantibodies in children at genetic risk. DESIGN Randomized, double-blind pilot trial (Finnish Dietary Intervention Tria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13dafe67d2277c8f3f67777a3e73a66
https://pubmed.ncbi.nlm.nih.gov/22393174

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