Zobrazeno 1 - 10
of 146
pro vyhledávání: '"H. Joseph Yost"'
Autor:
Craig Sable, Jennifer S. Li, Martin Tristani‐Firouzi, Angela Fagerlin, Robert M. Silver, Mark Yandel, H. Joseph Yost, Andrea Beaton, James Dale, Mark Emmanuel Engel, David Watkins, Christopher Spurney, Asheley C. Skinner, Sarah C. Armstrong, Svati H. Shah, Norrina Allen, Matthew Davis, Lifang Hou, Linda Van Horn, Darwin Labarthe, Donald Lloyd‐Jones, Bradley Marino
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
The American Heart Association's Strategically Focused Children's Research Network started in July 2017 with 4 unique programs at Children's National Hospital in Washington, DC; Duke University in Durham, North Carolina; University of Utah in Salt La
Externí odkaz:
https://doaj.org/article/a1c23aa891184b32b4c7b9d4ca6b6793
Autor:
W. Scott Watkins, E. Javier Hernandez, Sergiusz Wesolowski, Brent W. Bisgrove, Ryan T. Sunderland, Edwin Lin, Gordon Lemmon, Bradley L. Demarest, Thomas A. Miller, Daniel Bernstein, Martina Brueckner, Wendy K. Chung, Bruce D. Gelb, Elizabeth Goldmuntz, Jane W. Newburger, Christine E. Seidman, Yufeng Shen, H. Joseph Yost, Mark Yandell, Martin Tristani-Firouzi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Large whole-exome sequencing studies have suggested that the genetic architecture of syndromic congenital heart disease (CHD) is different from sporadic forms. Here, Watkins et al. estimate the relative contribution of damaging recessive and de novo
Externí odkaz:
https://doaj.org/article/8135b5f4cd6b48d3b81b0a72c696e63e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
A small percentage of cardiomyocytes (CM) are of neural crest origin but the function of such cells in the adult zebrafish is unclear. Here, the authors identify this CM subpopulation as expressing the Notch ligand jag2b and if deleted in the embryo,
Externí odkaz:
https://doaj.org/article/a31b2588da5a4210aa43a02306851e34
Autor:
Santhosh Karanth, J.D. Adams, Maria de los Angeles Serrano, Ezekiel B. Quittner-Strom, Judith Simcox, Claudio J. Villanueva, Lale Ozcan, William L. Holland, H. Joseph Yost, Adrian Vella, Amnon Schlegel
Publikováno v:
Cell Reports, Vol 24, Iss 2, Pp 312-319 (2018)
Summary: The common genetic variation at rs8004664 in the FOXN3 gene is independently and significantly associated with fasting blood glucose, but not insulin, in non-diabetic humans. Recently, we reported that primary hepatocytes from rs8004664 hype
Externí odkaz:
https://doaj.org/article/c4f7548fd33b421ea2c46f5ffbc12106
Publikováno v:
Cell Reports, Vol 15, Iss 12, Pp 2745-2755 (2016)
A SNP (rs8004664) in the first intron of the FOXN3 gene is associated with human fasting blood glucose. We find that carriers of the risk allele have higher hepatic expression of the transcriptional repressor FOXN3. Rat Foxn3 protein and zebrafish fo
Externí odkaz:
https://doaj.org/article/a83256eb2fb544c694fd12a58278a294
Autor:
Stefanie M. Percival, Holly R. Thomas, Adam Amsterdam, Andrew J. Carroll, Jacqueline A. Lees, H. Joseph Yost, John M. Parant
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 941-955 (2015)
Mutations in ESCO2, one of two establishment of cohesion factors necessary for proper sister chromatid cohesion (SCC), cause a spectrum of developmental defects in the autosomal-recessive disorder Roberts syndrome (RBS), warranting in vivo analysis o
Externí odkaz:
https://doaj.org/article/fcca61f82c304dd399fbee14cef5790b
Autor:
Joshua D. Wythe, Michael J. Jurynec, Lisa D. Urness, Christopher A. Jones, M. Khaled Sabeh, Andreas A. Werdich, Mariko Sato, H. Joseph Yost, David J. Grunwald, Calum A. MacRae, Dean Y. Li
Publikováno v:
Disease Models & Mechanisms, Vol 4, Iss 5, Pp 607-621 (2011)
SUMMARY The vertebrate heart is one of the first organs to form, and its early function and morphogenesis are crucial for continued embryonic development. Here we analyze the effects of loss of Heart adaptor protein 1 (Hadp1), which we show is requir
Externí odkaz:
https://doaj.org/article/70b4d00401de4ceda2f37e882d663460
Autor:
Shahram Eisa-Beygi, Meng-Ming Hu, Suresh N. Kumar, Brooke E. Jeffery, Ross F. Collery, Nghia (Jack) Vo, Bhawika S. Lamichanne, H. Joseph Yost, Matthew B. Veldman, Brian A. Link
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
BACKGROUND: The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation. METHODS: High resolution and time-la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c12e910ef5a1211ed7f34aaab9486d65
https://doi.org/10.1161/atvbaha.122.318622
https://doi.org/10.1161/atvbaha.122.318622
Autor:
Calum A. MacRae, Korak Chakraborti, H. Joseph Yost, Zachary P. Harmer, Manu Beerens, Jing-Ruey J. Yeh, Chelsea Herdman, Randall T. Peterson, Saba Parvez
Publikováno v:
Science
Screen time for CRISPR CRISPR-Cas9 has been used to edit the genomes of organisms ranging from fruit flies to primates, but it has not been used in large-scale genetic screens in animals because generating, validating, and keeping track of large numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5353a18c162b0832536a4237dc428a
https://doi.org/10.1126/science.abi8870
https://doi.org/10.1126/science.abi8870
Autor:
Sergiusz Wesolowski, Alex Henrie, Martin Tristani-Firouzi, Vikrant Deshmukh, Michael D. Puchalski, Karen Eilbeck, Mark Yandell, Thomas A. Miller, Rashmee U. Shah, Rebecca K. Delaney, H. Joseph Yost, Derek Weyhrauch, Edgar Javier Hernandez, Bruce E. Bray, Gordon Lemmon
Publikováno v:
PLOS digital health. 1(1)
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine. Here, we deploy a recently developed massively scalable comorbidity discovery method called Poisson Bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d805b42c1a56e79d21b3261499f5e60
https://pubmed.ncbi.nlm.nih.gov/35373216
https://pubmed.ncbi.nlm.nih.gov/35373216