Zobrazeno 1 - 10
of 44
pro vyhledávání: '"H. J. Zweerink"'
Autor:
Michael Edidin, Andrew J. McMichael, Taiyin Wei, Gil E. Katzenstein, Masanori Matsui, Jeffrey A. Frelinger, H J Zweerink, Maureen C. Gammon, Sarah Rowland-Jones, Robert J. Warburton
A combination of saturation and site-directed mutagenesis was utilized to disrupt the alpha 2 domain disulfide bridge of HLA-A*0201. Mutation of cysteine 101 to a serine (C101S) or of cysteine 164 to alanine (C164A) decreased the rate of maturation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d38a43857ea7d43a2f9a9baadb4008b
https://ora.ox.ac.uk/objects/uuid:54de532d-5363-4f5a-b041-4844526196f0
https://ora.ox.ac.uk/objects/uuid:54de532d-5363-4f5a-b041-4844526196f0
Autor:
Margaret A. Cascieri, Sander G. Mills, Malcolm MacCoss, Pasquale P. Vicario, H J Zweerink, William H. Parsons, Lihu Yang, Martin S. Springer, Liangqin Guo, Changyou Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:309-314
A series of racemic and homochiral α-aminothiazole-γ-aminobutyroamides that display high affinities for human and murine CCR2 and functional antagonism by inhibition of monocyte recruitment are described. A representative example is (2S)-2-[2-(acet
Autor:
Sheo B. Singh, H J Zweerink, Jon D. Polishook, Anne W. Dombrowski, Hiranthi Jayasuriya, Deborah L. Zink
Publikováno v:
Tetrahedron Letters. 45:7605-7608
Immunoglobin E (IgE) binds to the high-affinity IgE receptor on mast cells and basofils and causes release of inflammatory compounds that leads to allergic diseases. Inhibition of the ligand binding could lead to blockade of the release of inflammati
Autor:
Martin E. Dorf, Ulrich H. von Andrian, Wolfgang Weninger, Guiying Cheng, Antal Rot, Yi Luo, Steffen Jung, Barrett J. Rollins, H J Zweerink, Roger T. Palframan, Dan R. Littman
Publikováno v:
The Journal of Experimental Medicine
Interstitial fluid is constantly drained into lymph nodes (LNs) via afferent lymph vessels. This conduit enables monocyte-derived macrophages and dendritic cells to access LNs from peripheral tissues. We show that during inflammation in the skin, a s
Autor:
S Scott, Sandra L. Gould, Jayne Chin, Lorraine Malkowitz, Janet Lineberger, Salvatore J. Siciliano, Julie A. DeMartino, Hollis R. Williams, Lyndon J. Mitnaul, Michael D. Miller, Jerry DiSalvo, Mary Jo Staruch, Douglas W. Kawka, Irwin I. Singer, H J Zweerink, Martin S. Springer, Bruce L. Daugherty
Publikováno v:
Journal of Virology. 75:3779-3790
The chemokine receptors CCR5 and CXCR4 act synergistically with CD4 in an ordered multistep mechanism to allow the binding and entry of human immunodeficiency virus type 1 (HIV-1). The efficiency of such a coordinated mechanism depends on the spatial
Publikováno v:
Human Immunology. 46:18-26
To determine whether varied quantitative HLA expression affects the susceptibility of target cells to CTLs, a panel of 15 EBV-transformed lymphoblastoid cell lines expressing a fivefold difference of surface HLA-A2.1 antigens were employed. The susce
Autor:
H J Zweerink, William E. Biddison, Maureen C. Gammon, Samir Y. Sauma, Julio C. Hawkins, Bruce L. Bush, Snehal Tamhankar, Maria A. Bednarek, Gene Porter, Alan R. Williamson, Barry R. Cunningham, Jeffrey D. Hermes
Publikováno v:
Human Immunology. 37:252-258
Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed a
Autor:
H J Zweerink, M C Gammon, U Utz, S Y Sauma, T Harrer, J C Hawkins, R P Johnson, A Sirotina, J D Hermes, B D Walker
Publikováno v:
The Journal of Immunology. 150:1763-1771
The ability of minigene-encoded viral peptide epitopes to be presented by class I molecules in the absence of MHC-encoded transporters has been evaluated in mutant T2 cells. These cells have a large deletion in the class II MHC region that includes t
Autor:
M C Gammon, M A Bednarek, W E Biddison, S S Bondy, J D Hermes, G E Mark, A R Williamson, H J Zweerink
Publikováno v:
The Journal of Immunology. 148:7-12
Episomal plasmids (p8901) with minigenes coding for the influenza virus matrix peptide amino acids 57-68 (KGILGFVFTLTV; referred to as M57-68) or coding for a modified peptide were introduced into HLA-A2-positive target cells. The association of thes
Publikováno v:
The Journal of Immunology. 147:4047-4053
Influenza virus matrix protein-derived peptides were synthesized based on the amino acid motifs for HLA-A2 bound self peptides. Among these peptides a nonamer (amino acids 58 through 66: G I L G F V F T L) was found to be 100 to 1000 times more effec