Zobrazeno 1 - 10
of 51
pro vyhledávání: '"H. J. Showell"'
Autor:
J. Angilly, H. J. Showell, M. Mansour, S. J. Hawrylik, V. L. Cohan, Craig M. Lilly, M. J. Conklyn, B. Nalcerio, S. E. Lee, M. Karmilowicz, Dennis E. Danley, Jeffrey M. Drazen, J. R. De Wet, D. D. Auperin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 270:L1002-L1007
To study the role interleukin (IL)-5 may play in altering airway function in asthma, we have produced recombinant protein for exogenous administration to guinea pigs. The guinea pig IL-5 (gpIL-5) cDNA was cloned by polymerase chain reaction (PCR) amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fe82186f65574491fb1a082b2edf2
https://doi.org/10.1152/ajplung.1996.270.6.l1002
https://doi.org/10.1152/ajplung.1996.270.6.l1002
Autor:
K. Neote, Terence J. Hadley, J. Hesselgesser, Richard Horuk, Stephen C. Peiper, M. J. Conklyn, Zhao-Hai Lu, K. Ogborne, Zi-Xuan Wang, H. J. Showell, A. W. Martin
Publikováno v:
The Journal of Experimental Medicine
The Duffy antigen/receptor for chemokines (DARC), first identified on erythrocytes, functions not only as a promiscuous chemokine receptor but also as a receptor for the malarial parasite, Plasmodium vivax. The recent finding that DARC is ubiquitousl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb27e826f7e70af18ac81c33214b33f
https://doi.org/10.1084/jem.181.4.1311
https://doi.org/10.1084/jem.181.4.1311
Autor:
Norma P. Gerard, H J Showell, Lee F. Kolakowski, M J Conklyn, Carmen R. Bozic, C von Uexkull-Guldenband, Craig Gerard, R Breslow
Publikováno v:
Journal of Biological Chemistry. 269:29355-29358
KC, the product of an immediate early gene induced in mouse fibroblasts by platelet-derived growth factor, was synthesized as a recombinant protein in Escherichia coli and binds with 0.8 nM affinity to mouse neutrophils. Human neutrophils also bind r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b827a47ab329e1c0b51019934fa3332
https://doi.org/10.1016/s0021-9258(18)43882-3
https://doi.org/10.1016/s0021-9258(18)43882-3
Publikováno v:
The Journal of Immunology. 152:2479-2487
Human neutrophils were exposed to the chemotactic factors C5a, FMLP, IL-8, leukotriene B4, and PAF, for 30 s, and subsequently analyzed for protein tyrosine phosphorylation by immunoblotting whole cell lysates with a polyclonal antiphosphotyrosine Ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88bb3d28e5da330d70e9777f1d7744bd
https://doi.org/10.4049/jimmunol.152.5.2479
https://doi.org/10.4049/jimmunol.152.5.2479
Autor:
R N Pinckard, H J Showell, R Castillo, C Lear, R Breslow, L M McManus, D S Woodard, J C Ludwig
Publikováno v:
The Journal of Immunology. 148:3528-3535
The phlogistic actions of six molecular species of platelet-activating factor (PAF) (1-O-alkyl-PAF homologs, 16:0-, 18:0- and 18:1-alkyl-PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC) and their respective 1-acyl-PAF analog counterparts,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd55ee2fd70429b40a1b7297e9ad74a8
https://doi.org/10.4049/jimmunol.148.11.3528
https://doi.org/10.4049/jimmunol.148.11.3528
Publikováno v:
The Journal of Immunology. 148:106-111
IL-8, a potent neutrophil-activating protein, can be produced by many cell types including monocytes, lymphocytes, fibroblasts, neutrophils, and endothelial cells. Depending on the cell source, the N-terminal amino acid sequence of IL-8 displays hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::689f0aa29b9d04ade55e1f7306110661
https://doi.org/10.4049/jimmunol.148.1.106
https://doi.org/10.4049/jimmunol.148.1.106
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 78(10)
Experimental allergic encephalomyelitis is a murine model of preclinical autoimmune disease that has pathologic similarities to multiple sclerosis (MS). Although CD4+ T cells have been shown to play a crucial role in the development of disease, we re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::848532133a71fa6ec318226881652a3d
https://pubmed.ncbi.nlm.nih.gov/9800949
https://pubmed.ncbi.nlm.nih.gov/9800949
Autor:
H J, Showell, M J, Conklyn, R, Alpert, G P, Hingorani, K F, Wright, M A, Smith, E, Stam, E D, Salter, D N, Scampoli, S, Meltzer, L A, Reiter, K, Koch, A D, Piscopio, S R, Cortina, A, Lopez-Anaya, E R, Pettipher, A J, Milici, R J, Griffiths
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 285(3)
CP-195543 [(+)-2-(3-benzyl-4-hydroxy-chroman-7-yl)-4-trifluoromethyl-benzoic acid] is a structurally novel, selective and potent leukotriene B4 (LTB4) receptor antagonist. In vitro CP-195543 inhibited [3H]LTB4 binding to high-affinity LTB4 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8820a50f6b81802f34218a6f301f753
https://pubmed.ncbi.nlm.nih.gov/9618393
https://pubmed.ncbi.nlm.nih.gov/9618393
Autor:
J B, Cheng, J W, Watson, C J, Pazoles, J D, Eskra, R J, Griffiths, V L, Cohan, C R, Turner, H J, Showell, E R, Pettipher
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
Rolipram was previously reported to elevate plasma cyclic adenosine 3',5'-monophosphate (cAMP) and inhibit serum tumor necrosis factor-alpha (TNF-alpha) production in mice. CP-80,633, a new cyclic nucleotide phosphodiesterase (PDE4) inhibitor, has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::74190061f47b2e92bb53526ae046cbec
https://pubmed.ncbi.nlm.nih.gov/9023272
https://pubmed.ncbi.nlm.nih.gov/9023272
Autor:
M J, Conklyn, H J, Showell
Publikováno v:
Methods in enzymology. 287
We have described an assay that monitors the activating effects of a variety of chemokines on leukocyte subsets in human whole blood. This procedure has the following advantages: (1) minimal manipulation of the cells, (2) maintenance of more physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::523cdc23d8abaf162853f9c3cdc33bb2
https://pubmed.ncbi.nlm.nih.gov/9330334
https://pubmed.ncbi.nlm.nih.gov/9330334