Výsledky vyhledávání - "H. J. M. van Kan"

Impact of joint consultation by a clinical pharmacist and a clinical geriatrician to improve inappropriate prescribing for elderly patients

Autor: A. Kalf, P.M.L.A. van den Bemt, J.J.W. Ros, H J M Van Kan, T.J. Koekkoek

Publikováno v: European Journal Of Hospital Pharmacy-Sciene And Practice, 24(1), 26-U44. European Association of Hospital Pharmacists (EAHP)

Objective Appropriate prescribing is a key quality element in medication safety. It is unclear if therapeutic interventions resulting from medication review lead to clinically relevant improvements. The effect of medication review on prescribing appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7e08b88ce68a770696518460f2dd23
https://pure.eur.nl/en/publications/507cb527-a880-4581-a913-8fddd4079aed

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Association between CYP1A2 activity and riluzole clearance in patients with amyotrophic lateral sclerosis

Autor: Geert Jan Groeneveld, M. Spieksma, Henk-Jan Guchelaar, L. H. van den Berg, H. J. M. van Kan, S. Kalmijn

Publikováno v: British journal of clinical pharmacology, 59(3), 310-313. Wiley-Blackwell

Aims Riluzole is used in a fixed dosing schedule of 50 mg twice daily to treat patients with amyotropic lateral sclerosis (ALS), one form of motor neurone disease. The large variability in the pharmacokinetics of riluzole may be a factor contributing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c07a65f2349a02327cfdb3a5a22792a
https://doi.org/10.1111/j.1365-2125.2004.02233.x

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Plasma concentrations of meperidine and normeperidine following continuous intrathecal meperidine in patients with neuropathic cancer pain

Autor: J. H. Vranken, H. J. M. van Kan, M R Kruis, M H van der Vegt

Publikováno v: Acta anaesthesiologica Scandinavica, 49(5), 665-670. Blackwell Munksgaard

Background: Intrathecal administration of meperidine, an opioid with local anesthetic activity, can induce analgesia in patients with intractable cancer pain. However, continuous intrathecal administration may result in the accumulation of normeperid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0068b94afb81c6330ff6d48ba6c5019
https://doi.org/10.1111/j.1399-6576.2005.00667.x

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A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis

Autor: H. J. M. van Kan, L. H. van den Berg, Henk-Jan Guchelaar, M. Spieksma, Geert Jan Groeneveld, J. Sastre Toraño

Publikováno v: Biomedical Chromatography. 18:723-726

A specific, accurate and precise high-performance liquid chromatographic assay was developed for the determination of riluzole, a drug used to treat patients with amyotrophic lateral sclerosis. Samples were treated by extraction with dichloromethane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f30294f342d0c74d91c3a6db950d9fc
https://doi.org/10.1002/bmc.384

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High mortality among patients with bacterial meningitis in a rural hospital in Tanzania

Autor: L. Spanjaard, W. J. Wiersinga, H. J. M. van Kan, J. C. F. M. Wetsteyn, Q. M. van Dellen, A. L. Groen

Publikováno v: Annals of tropical medicine and parasitology, 98(3), 271-278. Maney Publishing

Although the disease is an important cause of mortality in the region, most published reports on bacterial meningitis in East Africa are from urban referral hospitals. Poor laboratory facilities make diagnosis difficult in the area and treatment is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc958a22fc9968d8069697129a2fcfa
https://doi.org/10.1179/000349804225003235

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Inter- and intraindividual variability of riluzole serum concentrations in patients with ALS

Autor: Henk-Jan Guchelaar, Geert Jan Groeneveld, L.H. van den Berg, H. J. M. van Kan, Jan H. Veldink, J. Sastre Toraño, John H. J. Wokke

Publikováno v: Journal of the Neurological Sciences. 191:121-125

All patients with amyotrophic lateral sclerosis (ALS) are treated with the same dose of riluzole: 50 mg twice daily. Reasonably large interindividual differences in clearance of the drug have been reported. The relatively small group of patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119b9879bcb3d40d36aca387b5573a18
https://doi.org/10.1016/s0022-510x(01)00613-x

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Pharmacokinetics of riluzole: evidence for glucuronidation as a major metabolic pathway not associated with UGT1A1 genotype

Autor: P.W.J. van Vught, Loraine Lie-A-Huen, Henk-Jan Guchelaar, H. J. M. van Kan, L.H. van den Berg, R.J.H.M. van der Straaten, Geert Jan Groeneveld

Publikováno v: Biopharmaceutics & drug disposition, 29(3), 139-144. John Wiley and Sons Ltd

Pharmacokinetic studies of riluzole show a large inter-individual variability of the drug's clearance and serum concentrations. Optimizing the individual dosage of riluzole may have the potential to improve the effect of riluzole treatment on surviva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5073310cab99edff83f95f2645d4c29
https://pubmed.ncbi.nlm.nih.gov/18098330

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[Severe phenytoin intoxication in patients with hypoalbuminaemia]

Autor: E M, Kemper, H J M, van Kan, P, Speelman, K, de Gans, J H, Beijnen, J H M, Schellens

Publikováno v: Nederlands tijdschrift voor geneeskunde. 151(2)

Two patients, a 35-year-old woman and a 60-year-old man, developed severe neurological side effects during treatment with phenytoin: disorientation, myoclonia, hallucinations and drowsiness in the first patient and a comatose state in the second. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a973a6b3cce1d5936aa4f2669ba8ce1
https://pubmed.ncbi.nlm.nih.gov/17520854

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A validated HPLC assay to monitor riluzole plasma or serum concentrations in patients with amyotrophic lateral sclerosis

Autor: H J M, van Kan, M, Spieksma, G J, Groeneveld, J Sastre, Toraño, L H, van den Berg, H J, Guchelaar

Publikováno v: Biomedical chromatography : BMC. 18(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e17f09a825cbad5ee2c57f8f3564b9dc
https://pubmed.ncbi.nlm.nih.gov/15386583

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Relative bioavailability of three newly developed albendazole formulations: a randomized crossover study with healthy volunteers

Autor: Henk-Jan Guchelaar, H.G. Schipper, H. J. M. van Kan, I.M. Rigter, Piet A. Kager, Richard P. Koopmans, Henderik W. Frijlink

Publikováno v: Antimicrobial Agents and Chemotherapy, 48(3), 1051-1054. AMER SOC MICROBIOLOGY
Antimicrobial agents and chemotherapy, 48(3), 1051-1054. American Society for Microbiology

This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-β-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5777aa34e37ebf2a78f3c77d68bac517
https://pubmed.ncbi.nlm.nih.gov/14982808

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