Zobrazeno 1 - 10 of 11 pro vyhledávání: '"H. J. M. Gijsen"'
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Akademický článek
BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory
Autor: A. Nash, H. J. M. Gijsen, B. J. Hrupka, K. S.-L. Teng, S. F. Lichtenthaler, H. Takeshima, J. M. Gunnersen, K. M. Munro
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient s
Externí odkaz: https://doaj.org/article/30fc73a123fe4f83943a0c12121c8a83
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2
BACE inhibitor treatment of mice induces hyperactivity in a Seizure-related gene 6 family dependent manner without altering learning and memory
Autor: Stefan F. Lichtenthaler, Brian Joel Hrupka, H. J. M. Gijsen, Hiroshi Takeshima, Kathleen Sue Lyn Teng, Jenny M. Gunnersen, Kathryn M. Munro, Amelia Nash
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific reports 11(1), 15084 (2021). doi:10.1038/s41598-021-94369-0
Scientific Reports
BACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient symptoms a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e0ac5c9959bc4bfafc3fcfeb50f8b7
https://doaj.org/article/30fc73a123fe4f83943a0c12121c8a83
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3
BACE Inhibitor Treatment in Mice Induces Hyperactivity in a Seizure-Related Gene 6 Family Protein Dependent Manner but Does Not alter Spatial Learning and Reference Memory
Autor: Brian Joel Hrupka, H. J. M. Gijsen, Hiroshi Takeshima, Amelia Nash, Kathryn M. Munro, K. S-L. Teng, Jenny M. Gunnersen, Stefan F. Lichtenthaler
BackgroundBACE inhibitors, which decrease BACE1 (β-secretase 1) cleavage of the amyloid precursor protein, are a potential treatment for Alzheimer’s disease. Clinical trials using BACE inhibitors have reported a lack of positive effect on patient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee73d7f53e2f0fe3a2f62895a01a9612
https://doi.org/10.21203/rs.3.rs-396650/v1
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The synthesis of (−)-kessane, starting from natural (+)-aromadendrene-II
Autor: Aede de Groot, Joannes B. P. A. Wijnberg, Gerrit A. Stork, H. J. M. Gijsen
Publikováno v: Tetrahedron. 47:4409-4416
Starting from the readily available chiral synthon 5 the sesquiterpene ether (−)-kessane (1) can be synthesized in a 9 steps reaction sequence in an overall yield of 43%.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32645f787a5b5be0477adfe74dd49ba2
https://doi.org/10.1016/s0040-4020(01)87109-x
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