Zobrazeno 1 - 10
of 320
pro vyhledávání: '"H. J. Kolker"'
Autor:
H. J. Kolker, G. Stoter, J. Ma, J.H.M. Schellens, Jaap Verweij, Marc Maliepaard, Kees Nooter, Walter J. Loos
Publikováno v:
British Journal of Cancer, 77(10), 1645-1652. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer
In order to unravel possible mechanisms of clinical resistance to topoisomerase I inhibitors, we developed a topotecan-resistant human IGROV-1 ovarian cancer cell line, denoted IGROV(T100r), by stepwise increased exposure to topotecan (TPT). The IGRO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce418f09126323e8726a74d10cf3afb
https://doi.org/10.1038/bjc.1998.270
https://doi.org/10.1038/bjc.1998.270
Publikováno v:
British Journal of Cancer
The profiles of an i.v. bolus and 3 h and 20 h infusion of cisplatin (CDDP) were simulated in vitro by using a culture of the IGROV1 human ovarian cancer cell line. Disappearance of pharmacologically active unbound CDDP was accomplished by adding hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41723f9df978c48044dd538173add878
https://doi.org/10.1038/bjc.1994.166
https://doi.org/10.1038/bjc.1994.166
Autor:
A. S. J. P. A. M. van Miert, G. A. E. T Klooster, H. J. Kolker, Renger F. Witkamp, Sandra M. Nijmeijer, Jan Noordhoek
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 16:55-62
Sulphadimidine (20 mg/kg i.v.) plasma elimination and metabolite formation were studied in intact male, castrated male, and female dwarf goats. Plasma pharmacokinetics and urinary metabolite patterns were first studied in untreated animals. Afterward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb1707be925825f295ef01df27bb325
https://doi.org/10.1111/j.1365-2885.1993.tb00289.x
https://doi.org/10.1111/j.1365-2885.1993.tb00289.x
Autor:
Adelbert S.J.P.A.M. van Miert, H. J. Kolker, Jan Noordhoek, Gerben A.E. van 't Klooster, Felice M.A. Woutersen-van Nijnanten
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 579:355-360
A high-performance liquid chromatographic method is presented for the determination of trimethoprim (TMP), 3'-hydroxy-TMP, 4'-hydroxy-TMP, α-hydroxy-TMP and two TMP N-oxides. The last two metabolites appear to decompose on liquid extraction. TMP and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584012cd1338d307f111d9581f8a53a0
https://doi.org/10.1016/0378-4347(92)80404-e
https://doi.org/10.1016/0378-4347(92)80404-e
Autor:
H. J. Kolker, Felice M.A. Woutersen-van Nijnanten, Jan Noordhoek, Gerben A.E. van 't Klooster, Adelbert S.J.P.A.M. van Miert
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 579:158-164
Ethylmorphine N-demethylation is used as a marker pathway in studies of rat cytochrome P450 3A and 2C11 biotransformations. At present, microsomal activities are generally measured by a colorimetric determination of the formed formaldehyde. In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8966818609ed8fe809abcfd05e3c516
https://doi.org/10.1016/0378-4347(92)80374-y
https://doi.org/10.1016/0378-4347(92)80374-y
Autor:
Jan Noordhoek, Sandra M. Nijmeijer, Renger F. Witkamp, A. S. J. P. A. M. van Miert, H. J. Kolker
Publikováno v:
Europe PubMed Central
Effects of recombinant bovine somatotrophin (r bst ) on in vivo and in vitro oxidative drug metabolism were studied in male rats. r bst was given subcutaneously at a dose of 250 or 500 μg 100 g −1 bodyweight 24 h −1 in different dosage patterns.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c629c1874124cdb6629a481e53ab9036
https://pubmed.ncbi.nlm.nih.gov/8378610
https://pubmed.ncbi.nlm.nih.gov/8378610
Autor:
G A, van 't Klooster, H J, Kolker, F M, Woutersen-van Nijnanten, J, Noordhoek, A S, van Miert
Publikováno v:
Journal of chromatography. 579(2)
A high-performance liquid chromatographic method is presented for the determination of trimethoprim (TMP), 3'-hydroxy-TMP, 4'-hydroxy-TMP, alpha-hydroxy-TMP and two TMP N-oxides. The last two metabolites appear to decompose on liquid extraction. TMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6afaa4354231151c26b2f9bca66050ef
https://pubmed.ncbi.nlm.nih.gov/1429985
https://pubmed.ncbi.nlm.nih.gov/1429985
Autor:
A. S. J. P. A. M. van Miert, J. A. C. M. Lohuis, H. J. Kolker, Renger F. Witkamp, Sandra M. Nijmeijer, Jan Noordhoek
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 21(11)
1. The plasma disposition of antipyrine, and its urinary metabolite pattern, were studied in both sexes of four animal species: rat, dwarf goat, rabbit and cattle. 2. No sex differences in plasma elimination of antipyrine were found in rabbit and goa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b4497c4aa7c0a6552678d6deb5e6b9
https://pubmed.ncbi.nlm.nih.gov/1763522
https://pubmed.ncbi.nlm.nih.gov/1763522
Autor:
Martin Karplus, H. J. Kolker
Publikováno v:
The Journal of Chemical Physics. 41:1259-1266
A variation‐perturbation method is employed for the calculation of the magnetic shielding tensor for the nuclei of a series of diatomic molecules (H2, Li2, N2, F2, LiH, HF, LiF). The SCF—LCAO—MO functions of Ransil are used as unperturbed solut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4bb2b570f46a734337033cf1206d35
https://doi.org/10.1063/1.1726058
https://doi.org/10.1063/1.1726058