Zobrazeno 1 - 10
of 149
pro vyhledávání: '"H. J. Gruss"'
Publikováno v:
Colorectal Disease. 16:36-50
Aims The 1R,2S stereoisomer of methoxamine hydrochloride, NRL001, is a highly selective α1-adrenoceptor agonist being developed for the local treatment of non-structural faecal incontinence caused by weak internal anal sphincter tone. This study inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81dbc501bdf0d8231438213edd2c7ce6
https://doi.org/10.1111/codi.12544
https://doi.org/10.1111/codi.12544
Publikováno v:
Colorectal Disease. 16:5-15
Aims This study aimed to assess the dose and volume effects of suppository preparations and safety of NRL001 (one of four possible stereoisomers of methoxamine hydrochloride) on anal sphincter tone using rectal suppositories in healthy adult voluntee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d768e1e8501d050675b4911ccf8c237
https://doi.org/10.1111/codi.12541
https://doi.org/10.1111/codi.12541
Publikováno v:
Colorectal Disease. 16:51-58
Aims NRL001 is a highly specific α1–adrenoceptor agonist currently under evaluation for the treatment of faecal incontinence caused by a weak internal anal sphincter. The aim of this meta-analysis was to quantify the effect of NRL001 on cardiovasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e8a0f07e361bbce061511e26ac0b30
https://doi.org/10.1111/codi.12545
https://doi.org/10.1111/codi.12545
Publikováno v:
Alimentary Pharmacology & Therapeutics. 37:876-886
Constipation is a common condition for which PEG 3350 is an established treatment and prucalopride has recently been approved for this indication.To compare the efficacy, safety and impact on quality of life (QoL) of PEG 3350 plus electrolytes (PEG 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b587440a26bd5a9ced4cee64c64e18
https://doi.org/10.1111/apt.12278
https://doi.org/10.1111/apt.12278
Publikováno v:
Journal of Medical Economics. 15:758-765
With the availability of several bowel cleansing agents, physicians and hospitals performing colonoscopies will often base their choice of cleansing agent purely on acquisition cost. Therefore, an easy to use budget impact model has been developed an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::587a666c0b61e2ab80ca86b6879894aa
https://doi.org/10.3111/13696998.2012.670173
https://doi.org/10.3111/13696998.2012.670173
Autor:
V. G. Wilson, H. J. Gruss, Dashwood, J Simpson, Austin G. Acheson, S. J. Rayment, T. Eames, John H Scholefield, Y. Henry
Publikováno v:
British Journal of Pharmacology. 160:1727-1740
BACKGROUND AND PURPOSE We have investigated the distribution of α-adrenoceptors in sheep internal anal sphincter (IAS), as a model for the human tissue, and evaluated various imidazoline derivatives for potential treatment of faecal incontinence. EX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2643037d53b61c6d610b9e827af8a61a
https://doi.org/10.1111/j.1476-5381.2010.00842.x
https://doi.org/10.1111/j.1476-5381.2010.00842.x
Publikováno v:
British Journal of Surgery. 94:1155-1161
Background This study examined the effects of a single dose of intra-anal l-erythro methoxamine on mean anal resting pressure (MARP) and cardiovascular variables in patients with faecal incontinence. Methods Patients had anorectal physiology tests an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0bb434bf1d6238378eff1b354c4f3e
https://doi.org/10.1002/bjs.5821
https://doi.org/10.1002/bjs.5821
Autor:
H.-J. Gruss, Hans G. Drexler, Bernd Dörken, Wolf-Dieter Ludwig, V. Ruppert, Leonid Karawajew, Christian Wuchter
Publikováno v:
Leukemia. 11:1245-1252
CD95 (Fas/APO-1) is a cell surface receptor able to trigger apoptosis in a variety of cell types. The expression and function of the CD95 antigen on leukemic blasts from 42 patients with B lineage and 53 patients with T lineage acute lymphoblastic le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa9d2546d364b617db5cec910929f45
https://doi.org/10.1038/sj.leu.2400746
https://doi.org/10.1038/sj.leu.2400746
Autor:
S. J. Rayment, Austin G. Acheson, H. J. Gruss, Y. Henry, V. G. Wilson, T. Eames, Michael R. Dashwood, John H. Scholefield, J Simpson
Publikováno v:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 26(8)
Background The role of α-adrenoceptors in promoting continence through modulation of sphincter tone has focused primarily on the effects of α1-adrenoceptors. We have used three clinically available agents, which are selective for α2-adrenoceptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a23859410fc565941ab1fff0397e8276
https://pubmed.ncbi.nlm.nih.gov/24906134
https://pubmed.ncbi.nlm.nih.gov/24906134
Publikováno v:
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 16
Aims This study aimed to assess the effects of a single dose of 10 mg NRL001 (the 1R,2S stereoisomer of methoxamine hydrochloride) in a 2 g suppository on pharmacodynamic and pharmacokinetic (PK) variables, and safety, in a healthy elderly population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c347b98b52e175b0030b7349f320b188
https://pubmed.ncbi.nlm.nih.gov/24499494
https://pubmed.ncbi.nlm.nih.gov/24499494